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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	CHEMBL1935597
Molecular formula	C19H16F3NO3S
IUPAC name	1-(difluoromethyl)-7-(3-fluorophenyl)sulfonyl-1-methyl-3,4-dihydro-2H-[1]benzofuro[2,3-c]pyridine
Molecular weight	395.396
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.7
Synonyms	SCHEMBL16550821 BDBM50361057
Inchi Key	KJOGLIKJNJFQMM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16F3NO3S/c1-19(18(21)22)17-15(7-8-23-19)14-6-5-13(10-16(14)26-17)27(24,25)12-4-2-3-11(20)9-12/h2-6,9-10,18,23H,7-8H2,1H3
PubChem CID	57402187
ChEMBL	CHEMBL1935597
IUPHAR	N/A
BindingDB	50361057
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	183.0 nM	PMID22153937	BindingDB,ChEMBL

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