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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL87797
Molecular formula	C28H28N2O5S2
IUPAC name	1-[[2-[4-[3-(3-methylphenoxy)propoxy]phenyl]phenyl]methyl]-3-thiophen-2-ylsulfonylurea
Molecular weight	536.661
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	6.0
Synonyms	BDBM50117698 N-({[(4''-(3-[3-methylphenyl]-propoxy)-1,1''-biphenyl-2-yl)methyl]amino}carbonyl)thiophene-2-sulfonamide 1-[4'-[3-(3-Methylphenoxy)propoxy]-2-biphenylylmethyl]-3-(2-thienylsulfonyl)urea
Inchi Key	AXSQIUFBWNPAML-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H28N2O5S2/c1-21-7-4-9-25(19-21)35-17-6-16-34-24-14-12-22(13-15-24)26-10-3-2-8-23(26)20-29-28(31)30-37(32,33)27-11-5-18-36-27/h2-5,7-15,18-19H,6,16-17,20H2,1H3,(H2,29,30,31)
PubChem CID	44320388
ChEMBL	CHEMBL87797
IUPHAR	N/A
BindingDB	50117698
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	8600.0 nM	PMID12182865	BindingDB,ChEMBL

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