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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL197054
Molecular formulaC28H30N6O3
IUPAC name1-[2-[5-[(4-phenoxyphenyl)carbamoylamino]indazol-1-yl]ethyl]piperidine-4-carboxamide
Molecular weight498.587
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP3.0
Synonyms1-(2-{5-[3-(4-Phenoxy-phenyl)-ureido]-indazol-1-yl}-ethyl)-piperidine-4-carboxylic acid amide
BDBM50167571
SCHEMBL6070026
Inchi KeyKIOITPZEEHNURK-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H30N6O3/c29-27(35)20-12-14-33(15-13-20)16-17-34-26-11-8-23(18-21(26)19-30-34)32-28(36)31-22-6-9-25(10-7-22)37-24-4-2-1-3-5-24/h1-11,18-20H,12-17H2,(H2,29,35)(H2,31,32,36)
PubChem CID11386451
ChEMBLCHEMBL197054
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50134.0 nMPMID15911251ChEMBL

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