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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 3
Species	Homo sapiens (Human)
Gene	HCAR3
Synonym	G-protein coupled receptor 109B Nicotinic acid receptor 2 Nic2 NIACR2 Niacin receptor 2 Low affinity nicotinic acid receptor G protein-coupled receptor 109B G-protein coupled receptor HM74B G-protein coupled receptor HM74 HCA3 receptor [ Show all ]
Disease	N/A
Length	387
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
UniProt	P49019
Protein Data Bank	N/A
GPCR-HGmod model	P49019
3D structure model	This predicted structure model is from GPCR-EXP P49019.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4421
IUPHAR	313
DrugBank	BE0000836

Ligand

Name	CHEMBL202427
Molecular formula	C15H13N3O3
IUPAC name	1-[(3-methoxyphenyl)methyl]benzotriazole-5-carboxylic acid
Molecular weight	283.287
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.2
Synonyms	MCULE-8697059566 1-(3-METHOXY-BENZYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID SCHEMBL6043919 AKOS002020125 CTK7A9438
Inchi Key	KGPUIRFHPDEBMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H13N3O3/c1-21-12-4-2-3-10(7-12)9-18-14-6-5-11(15(19)20)8-13(14)16-17-18/h2-8H,9H2,1H3,(H,19,20)
PubChem CID	9971057
ChEMBL	CHEMBL202427
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5011.87 nM	PMID16480258	ChEMBL

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