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GPCR

Name	Histamine H1 receptor
Species	Homo sapiens (Human)
Gene	HRH1
Synonym	HH1R H1R Hisr H1 receptor
Disease	Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder Insomnia Hypersensitivity reactions; Coughs; Common colds Pain Parkinson's disease Perennial and seasonal allergic rhinitis; Vasomotor rhinitis; Allergic conjunctivitis Vertigo meniere's disease Unspecified Sleep disorders Seasonal and perennial allergic rhinitis and vasomotor rhinitis Rhinitis; Urticaria; Allergy Rhinitis Respiratory disease Respiratory allergies; Cancer Respiratory allergies; Allergic rhinitis Pruritus Nasal congestion Hay fever; Cough Hay fever; Allergic rhinitis Anxiety disorder Anesthesia Allergy Allergic skin disorders Allergic rhinitis; Urticaria; Pruritus Allergic rhinitis; Urticaria Allergic rhinitis Allergic disorders; Itching; Nausea Allergic conjunctivitis Anxiety disorder; Morning sickness Asthma Hay fever Common cold; Allergies Depression Dry cough [ Show all ]
Length	487
Amino acid sequence	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
UniProt	P35367
Protein Data Bank	3rze
GPCR-HGmod model	P35367
3D structure model	This structure is from PDB ID 3rze.
BioLiP	BL0202178, BL0202179, BL0202180
Therapeutic Target Database	T77913
ChEMBL	CHEMBL231
IUPHAR	262
DrugBank	BE0000442

Ligand

Name	Pipamperone
Molecular formula	C21H30FN3O2
IUPAC name	1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide
Molecular weight	375.488
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.0
Synonyms	Pipamperone (USAN/INN) 1 inverted exclamation mark -(3-(p-fluorobenzoyl)propyl)(1,4 inverted exclamation mark -bipiperidine)-4 inverted exclamation mark -carboxamide Piperonil 1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)- SCHEMBL2412 1893-33-0 C21H30FN3O2 D00DBO Floropipamide McN-JR-3345 P2315 Pharmakon1600-01505690 pipamperone hydrochloride 1'-(3-(p-Fluorobenzoyl)propyl)-(1,4'-bipiperidine)-4'-carboxamide Propitan (Salt/Mix) 1-(4-fluorophenyl)-4-(4-piperidino-4-carbamoylpiperidino)-1-butanone UNII-5402501F0W 4 inverted exclamation mark -bipiperidine)-4 inverted exclamation mark -carboxamide,1 inverted exclamation mark -(4-(4-fluorophenyl)-4-oxobutyl)-( AN-6479 CCG-213514 DB09286 HMS3264G14 NSC-759178 Pipamperona [INN-Spanish] (1,4'-Bipiperidine)-4'-carboxamide, 1'-(4-(4-fluorophenyl)-4-oxobutyl)- Pipamperonum [INN-Latin] 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide R4050 150093-EP2280012A2 [1,4'-Bipiperidine]-4'-carboxamide,1'-[4-(4-fluorophenyl)-4-oxobutyl]- 5402501F0W BRD-K26801045-001-01-1 CHEMBL440294 Dipiperone L000727 p-Fluoro-.gamma.-(4-piperidino-4-carbamoylpiperidino)butyrophenone PDSP1_001560 PIPAMPERONE DIHYDROCHLORIDE APPROX. 99 1'-(3-(4-fluorobenzoyl)propyl)-(1,4'-bipiperidine) -4'-carboxamide Piperonyl 1,4'-Bipiperidine]-4'-carboxamide, 1'-[4-(4-fluorophenyl)-4-oxobutyl]- SR-05000001930 2448-68-2 (di-hydrochloride) AB01563106_01 Carpiperone D02622 Fluoropipamide NCGC00165864-01 Pipamperon Pipamperone [USAN:INN:BAN] 1'-(4-(4-fluorophenyl)-4-oxobutyl)-1,4'-bipiperidine-4'-carboxamide R 3345 1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-(1-piperidyl)piperidine-4-carboxamide ZINC21297287 4'-Fluoro-4-(4-N-piperidino-4-carbamidopiperidino)butyrophenone AXKPFOAXAHJUAG-UHFFFAOYSA-N CCRIS 9071 Dipiperal Isonipacotamide, 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino- NSC759178 Pipaneperone 1'-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4'-bipiperidine]-4'-carboxamide Hydrochloride SBI-0206899.P001 150093-EP2289894A2 BRN 0496532 CTK7F7159 DTXSID8048369 LS-44586 p-Fluoro-gamma-(4-piperidino-4-carbamoylpiperidino)butyrophenone PDSP2_001544 Pipamperone HCl 1'-(3-(p-Fluorobenzoyl)propyl)(1,4'-bipiperidine)-4'-carboxamide Propitan 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino-isonipacotamid SR-05000001930-1 4 inverted exclamation mark -bipiperidine)-4 inverted exclamation mark -carboxamide,1 inverted exclamation mark -(3-(p-fluorobenzoyl)propyl)-( AC1L1J1T CAS_1893-33-0 GTPL92 NCGC00165864-02 Pipamperona (1,4'-BIPIPERIDINE)-4'-CARBOXAMIDE, 1'-(3-(p-FLUOROBENZOYL)PROPYL)- Pipamperonum 1'-[4-(4-fluorophenyl)-4-oxobutyl]-1,4'-bipiperidine-4'-carboxamide R-3345 1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide [1,4'-Bipiperidine]-4'-carboxamide, 1'-[4-(4-fluorophenyl)-4-oxobutyl]- 5-22-13-00536 (Beilstein Handbook Reference) BDBM81483 CHEBI:78549 Dipiperon Isonipecotamide, 1-(3-(p-fluorobenzoyl)propyl)-4-piperidino- NSC_4830 [ Show all ]
Inchi Key	AXKPFOAXAHJUAG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)
PubChem CID	4830
ChEMBL	N/A
IUPHAR	92
BindingDB	81483
DrugBank	DB09286
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2400.0 nM	PMID8935801	PDSP,BindingDB
Ki	2511.89 nM	PMID8935801	IUPHAR

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