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GPCR

Name	Succinate receptor 1
Species	Homo sapiens (Human)
Gene	SUCNR1
Synonym	succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 G-protein coupled receptor 91 G protein-coupled receptor 91 SUCNR1 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProt	Q9BXA5
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXA5
3D structure model	This predicted structure model is from GPCR-EXP Q9BXA5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150838
IUPHAR	166
DrugBank	BE0002258

Ligand

Name	succinic acid
Molecular formula	C4H6O4
IUPAC name	butanedioic acid
Molecular weight	118.088
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	-0.6
Synonyms	98-EP2284160A1 C4H6O4 98-EP2308873A1 98-EP2287156A1 DB00139 98-EP2311818A1 98-EP2314581A1 98-EP2289883A1 EC 203-740-4 98-EP2316825A1 98-EP2292619A1 F2191-0239 110-15-6 98-EP2316836A1 98-EP2295433A2 InChI=1/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8 47632-EP2311811A1 98-EP2374454A1 98-EP2298748A2 Kyselina jantarova [Czech] 98-EP2269986A1 AC1Q757B 98-EP2301922A1 Nat.Succinic Acid 98-EP2270011A1 AK111253 98-EP2305633A1 NSC 106449 98-EP2275413A1 BBL002473 98-EP2305659A1 Sal succini 98-EP2280006A1 BRN 1754069 98-EP2308849A1 SR-01000944556-2 Succinellite SUCCINIC ACID, ACS Succinic acid, matrix substance for MALDI-MS, >=99.5% (T), Ultra pure Succinic acid, SAJ special grade, >=99.5% Succinicun acidum UNII-AB6MNQ6J6L 98-EP2308854A1 STK387105 98-EP2284178A2 CHEMBL576 98-EP2311808A1 98-EP2311842A2 98-EP2287162A1 DSSTox_CID_3602 98-EP2311834A1 98-EP2314588A1 98-EP2292231A1 Ethanedicarboxylic acid 1,2-Ethanedicarboxylic acid 98-EP2316828A1 98-EP2295406A1 HOOC-CH2-CH2-COOH 2087491-34-5 98-EP2371800A1 98-EP2298734A2 KB-60642 623158-99-6 98-EP2380874A2 98-EP2298759A1 LS40373 98-EP2269990A1 acide succinique 98-EP2301937A1 NCGC00159372-04 98-EP2272537A2 Amber acid, Butanedioic acid, Ethylenesuccinic acid 98-EP2305646A1 NSC106449 98-EP2277848A1 Bernsteinsaure 98-EP2305673A1 SC-47173 98-EP2281563A1 butanedioic acid Succinic Acid (SA) Succinic acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.0% Succinic Acid, Pharmaceutical Secondary Standard; Certified Reference Material Succinic Acide,(S) Tox21_111612_1 Wormwood acid 98-EP2284147A2 Butanedionic acid 98-EP2308869A1 98-EP2287153A1 D06VNK 98-EP2311811A1 98-EP2314575A1 98-EP2289876A1 DTXSID6023602 98-EP2316458A1 98-EP2292611A1 ethylenedicarboxylic acid 1,4-BUTANEDIOIC ACID (SUCCINIC ACID) 98-EP2316834A1 98-EP2295426A1 I04-1083 4-02-00-01908 (Beilstein Handbook Reference) 98-EP2371805A1 98-EP2298746A1 KSC175Q2B 98-EP2269983A1 AB6MNQ6J6L 98-EP2298775A1 MolPort-000-871-623 98-EP2270006A1 AI3-06297 98-EP2305248A1 NCGC00257092-01 98-EP2275411A2 ANW-16131 98-EP2305655A2 RTR-002122 98-EP2277867A2 bmse000968 98-EP2305679A1 Spirit of amber succinate Succinic acid, 99% Succinic acid, certified reference material, TraceCERT(R) Succinic acid, ReagentPlus(R), >=99.0% Succinicate TR-002122 ST24031670 98-EP2284165A1 CAS-110-15-6 98-EP2308875A1 98-EP2287160A1 Dihydrofumarate 98-EP2311829A1 98-EP2314585A1 98-EP2289890A1 EINECS 203-740-4 98-EP2316826A1 98-EP2295401A2 FT-0652509 196539-EP2270007A1 98-EP2371797A1 98-EP2295437A1 J-002386 4CN-0813 98-EP2374780A1 98-EP2298757A2 LMFA01170043 98-EP2269988A2 Acid of amber 98-EP2301924A1 NCGC00159372-02 98-EP2270505A1 AKOS000118899 98-EP2305636A1 NSC-106449 98-EP2275414A1 BDBM26121 98-EP2305663A1 Salt of amber 98-EP2280010A2 Butandisaeure 98-EP2308850A1 Succinic acid, ACS reagent Succinic acid, natural Succinic acid, United States Pharmacopeia (USP) Reference Standard T7308 WLN: QV2VQ 98-EP2308857A1 Substrate analogue, 11 98-EP2284179A2 CS-0008946 98-EP2311809A1 98-EP2314295A1 98-EP2289510A1 DSSTox_GSID_23602 98-EP2311837A1 98-EP2314593A1 98-EP2292234A1 Ethylene dicarboxylic acid 1,4-Butanedioate 98-EP2316829A1 98-EP2295416A2 HSDB 791 98-EP2371802A1 98-EP2298735A1 KDYFGRWQOYBRFD-UHFFFAOYSA-N 6283-68-7 A 12084 98-EP2298768A1 MCULE-5889111640 98-EP2270002A1 Acidum succinicum 98-EP2301940A1 NCGC00159372-05 98-EP2272827A1 Ammonium succinate 98-EP2305651A1 NSC25949 98-EP2277858A1 Bernsteinsaure [German] 98-EP2305675A1 SIN 98-EP2281819A1 Butanedioic acid (9CI) Succinic acid [NF] Succinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture Succinic acid, puriss. p.a., ACS reagent, >=99.5% (T) succinicacid Tox21_201918 Z57127453 98-EP2284149A1 C00042 98-EP2308872A1 98-EP2287155A1 98-EP2311814A1 98-EP2314576A1 98-EP2289879A1 E363 98-EP2316459A1 98-EP2292617A1 ethylenesuccinic acid 1,4-BUTANEDIOIC ACID (SUCCINIC ACID) 98-EP2316835A1 98-EP2295427A1 I847 47632-EP2281817A1 98-EP2372017A1 98-EP2298747A1 Kyselina jantarova 98-EP2269984A1 AC1L1AQW 98-EP2301544A1 N1941 98-EP2270008A1 AJ-24134 98-EP2305257A1 NCGC00259467-01 98-EP2275412A1 Asuccin 98-EP2305657A2 S0100 98-EP2280003A2 BP-21128 98-EP2308839A1 SR-01000944556 succinate, 9 Succinic acid, >=99%, FCC, FG Succinic acid, FCC Succinic acid, SAJ first grade, >=99.0% Succinicum acidum TRA0035567 98-EP2308851A1 ST50213944 98-EP2284169A1 CHEBI:15741 98-EP2311807A1 98-EP2287161A1 Dihydrofumaric acid 98-EP2311831A1 98-EP2314586A1 98-EP2292227A2 ethane-1,2-dicarboxylic acid 1,2-Ethanedicarboxylate 98-EP2316827A1 98-EP2295402A2 GTPL3637 1cze 98-EP2371798A1 98-EP2298731A1 Katasuccin 4lh2 98-EP2374781A1 98-EP2298758A1 LS-147378 98-EP2269989A1 acide butanedioique 98-EP2301931A1 NCGC00159372-03 98-EP2272516A2 Amber acid 98-EP2305641A1 NSC-25949 98-EP2277507A1 Bernsteinsaeure 98-EP2305664A1 SBB040562 98-EP2281559A1 Butane diacid Succinic acid (8CI) Succinic acid, ACS reagent, >=99.0% Succinic acid, p.a., ACS reagent, 99.0% Succinic acid, Vetec(TM) reagent grade, 98% Tox21_111612 Wormwood 98-EP2308861A1 succ 98-EP2286795A1 CTK0H5820 98-EP2311810A1 98-EP2314574A1 98-EP2289518A1 DSSTox_RID_77102 98-EP2316457A1 98-EP2292592A1 Ethylene succinic acid 1,4-Butanedioic acid 98-EP2316831A1 98-EP2295424A1 HY-N0420 37E8FFFB-70DA-4399-B724-476BD8715EF0 98-EP2371804A1 98-EP2298742A1 KS-00000UER 98-EP2269610A2 AB01332192-02 98-EP2298772A1 MFCD00002789 98-EP2270003A1 ACMC-20995h 98-EP2305219A1 NCGC00159372-06 98-EP2275401A1 AN-22587 98-EP2305653A1 RP19292 98-EP2277866A1 bmse000183 98-EP2305676A1 sodium succinate (anhydrous) 98-EP2284146A2 Butanedioic acid diammonium salt Succinic acid, 6 Succinic acid, BioXtra, >=99.0% Succinic acid, purum p.a., >=99.0% (T) SuccinicAcid(IndustrialGrade&FoodGrade) Tox21_303247 ZINC895030 [ Show all ]
Inchi Key	KDYFGRWQOYBRFD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
PubChem CID	1110
ChEMBL	N/A
IUPHAR	3637
BindingDB	N/A
DrugBank	DB00139
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	20000.0 - 91000.0 nM	PMID15141213, PMID23396314	IUPHAR

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