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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2086686
Molecular formulaC21H23N7O3
IUPAC name2-cyanopropan-2-yl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
Molecular weight421.461
Hydrogen bond acceptor9
Hydrogen bond donor0
XlogP1.3
SynonymsBDBM50420840
SCHEMBL1448281
Inchi KeyAXCPODYQWVLWMM-OAHLLOKOSA-N
Inchi IDInChI=1S/C21H23N7O3/c1-15-12-27(20(29)31-21(2,3)14-23)6-7-28(15)19-25-10-18(11-26-19)30-13-16-4-5-24-9-17(16)8-22/h4-5,9-11,15H,6-7,12-13H2,1-3H3/t15-/m1/s1
PubChem CID51030529
ChEMBLCHEMBL2086686
IUPHARN/A
BindingDB50420840
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501055.0 nMPMID22545772BindingDB,ChEMBL
Intrinsic activity122.0 %PMID22545772ChEMBL

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