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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	ARGIPRESSIN
Molecular formula	C46H65N15O12S2
IUPAC name	(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Molecular weight	1084.24
Hydrogen bond acceptor	16
Hydrogen bond donor	14
XlogP	-4.8
Synonyms	DSSTox_CID_28324 L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginylglycinamide Cyclic (1 inverted exclamation marku6)-Disulfide Diacetate Pitressin 1-{[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide Tox21_113037 Vasopressin, 8-L-arginine- American Regent Brand of Vasopressin [Arg8]-Vasopressin Arginine vasopressin Argipressin Diacetate Argipressinum beta-Hypophamine DTXSID0048349 NCGC00166306-01 Rindervasopressin 19-Amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide Diacetate Vasopressin (arginine form) 8-L-Arginine-vasopressin [3H]arginine vasopressin Arg-vasopressin Arginine-8-vasopressin Diacetate Argipressin [INN:BAN] AVP Diacetate Glycinamide, L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-, cyclic (1>6)-disulfide Oxytocin, 3-(L-phenylalanine)-8-L-arginine- (Arg8)-Vasopressin SCHEMBL17874853 3-(Phenylalanine)-8-arginineoxytocin Vasopressin Monarch Brand AKOS030529553 [8-Arginine]vasopressin Arginine antidiuretic hormone Argipresina Argipressine BDBM50044777 D02983 DSSTox_GSID_48349 Leiormone Diacetate Pitressin Diacetate 113-79-1 UNII-Y4907O6MFD 8-Arginine-vasopressin Vasopressin, 8-L-arginine- (7CI,8CI,9CI) Antidiuretic hormone [cyclo S-S]CYFQNCPRG-NH2 Arginine Vasopressin Diacetate Argipressin tannate (USAN) Argipressinum [INN-Latin] CAS-113-79-1 EBD54999 NCGC00166306-02 (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminom Rindervasopressin Diacetate Vasopressin (JP15/USP) 8-L-Arginine-vasopressin Diacetate [3H]Argipressin tannate Arg8-vasopressin Arginine-vasopressin Argipressin [INN] BC660199 CHEMBL373742 GTPL2168 Parke-Davis Brand of Vasopressin (USP) 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide, 19-amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hyd SCHEMBL43139 Vasopressin(Argipressin) American Pharmaceutical Brand of Vasopressin [8-Arginine]vasopressin Diacetate Arginine antidiuretic hormone Diacetate Argipressine [INN-French] beta Hypophamine D0N4OW DSSTox_RID_82752 Monarch Brand of Vasopressin Pitressin tannate (TN) 113A791 Vasophysin 8-L-Arginine vasopressin Y4907O6MFD Antidiuretic Hormones Arginine-8-vasopressin Argipressin tannate [USAN] AVP CHEBI:34543 EINECS 204-035-4 NCGC00188439-01 (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(d roxybenzyl-6,9,12,15,18-pentaoxo- (6CI) 3-(L-Phenylalanine)-8-L-arginine-oxytocin Diacetate Vasopressin (USP) AC1LD8IN [3H]vasopressin Arg8-vasopressin Diacetate Arginine-vasopressin Diacetate Argipressina BDBM35667 Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2[Disulfide Bridge: 1-6] [ Show all ]
Inchi Key	KBZOIRJILGZLEJ-LGYYRGKSSA-N
Inchi ID	InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PubChem CID	644077
ChEMBL	CHEMBL373742
IUPHAR	2168
BindingDB	50044777, 35667
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Antidiuretic activity	323.0 U mg-1	PMID7752199	ChEMBL
Kact	0.32 nM	PMID17300166	ChEMBL
Kd	1.5 nM	PMID10201826	BindingDB,ChEMBL
Ki	0.45 nM	PMID17300166	ChEMBL
Ki	0.46 nM	PMID9223568	BindingDB
Ki	0.95 nM	PMID9864265	BindingDB
Ki	3.23 nM	PMID9223568	BindingDB

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