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GPCR

Name	Vasopressin V1b receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr1b
Synonym	Vasopressin V3 receptor vasopressin V1b receptor V3/V1b pituitary vasopressin receptor V3 V1bR V1B receptor AVPR3 AVPR V3 AVPR V1b Antidiuretic hormone receptor 1b VPR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	425
Amino acid sequence	MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLGRHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQGSGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREERRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGSKPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATMETSIF
UniProt	P48974
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2659
IUPHAR	367
DrugBank	N/A

Ligand

Name	ARGIPRESSIN
Molecular formula	C46H65N15O12S2
IUPAC name	(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Molecular weight	1084.24
Hydrogen bond acceptor	16
Hydrogen bond donor	14
XlogP	-4.8
Synonyms	8-L-Arginine-vasopressin [3H]arginine vasopressin Arg-vasopressin Arginine-8-vasopressin Diacetate Argipressin [INN:BAN] AVP Diacetate DTXSID0048349 NCGC00166306-01 Rindervasopressin 19-Amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hydroxybenzyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide Diacetate Vasopressin (arginine form) Vasopressin Monarch Brand AKOS030529553 [8-Arginine]vasopressin Arginine antidiuretic hormone Argipresina Argipressine BDBM50044777 D02983 Glycinamide, L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginyl-, cyclic (1>6)-disulfide Oxytocin, 3-(L-phenylalanine)-8-L-arginine- (Arg8)-Vasopressin SCHEMBL17874853 3-(Phenylalanine)-8-arginineoxytocin 8-Arginine-vasopressin Vasopressin, 8-L-arginine- (7CI,8CI,9CI) Antidiuretic hormone [cyclo S-S]CYFQNCPRG-NH2 Arginine Vasopressin Diacetate Argipressin tannate (USAN) Argipressinum [INN-Latin] CAS-113-79-1 DSSTox_GSID_48349 Leiormone Diacetate Pitressin Diacetate 113-79-1 UNII-Y4907O6MFD Vasopressin (JP15/USP) 8-L-Arginine-vasopressin Diacetate [3H]Argipressin tannate Arg8-vasopressin Arginine-vasopressin Argipressin [INN] BC660199 CHEMBL373742 EBD54999 NCGC00166306-02 (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminom Rindervasopressin Diacetate Vasopressin(Argipressin) American Pharmaceutical Brand of Vasopressin [8-Arginine]vasopressin Diacetate Arginine antidiuretic hormone Diacetate Argipressine [INN-French] beta Hypophamine D0N4OW GTPL2168 Parke-Davis Brand of Vasopressin (USP) 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane-10-propionamide, 19-amino-13-benzyl-7-(carbamoylmethyl)-4-[2-[[1-[(carbamoylmethyl)carbamoyl]-4-guanidinobutyl]carbamoyl]-1-pyrrolidinylcarbonyl]-16-p-hyd SCHEMBL43139 8-L-Arginine vasopressin Y4907O6MFD Antidiuretic Hormones Arginine-8-vasopressin Argipressin tannate [USAN] AVP CHEBI:34543 DSSTox_RID_82752 Monarch Brand of Vasopressin Pitressin tannate (TN) 113A791 Vasophysin Vasopressin (USP) AC1LD8IN [3H]vasopressin Arg8-vasopressin Diacetate Arginine-vasopressin Diacetate Argipressina BDBM35667 Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2[Disulfide Bridge: 1-6] EINECS 204-035-4 NCGC00188439-01 (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(d roxybenzyl-6,9,12,15,18-pentaoxo- (6CI) 3-(L-Phenylalanine)-8-L-arginine-oxytocin Diacetate Vasopressin, 8-L-arginine- American Regent Brand of Vasopressin [Arg8]-Vasopressin Arginine vasopressin Argipressin Diacetate Argipressinum beta-Hypophamine DSSTox_CID_28324 L-Cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-arginylglycinamide Cyclic (1 inverted exclamation marku6)-Disulfide Diacetate Pitressin 1-{[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-prolyl-L-arginylglycinamide Tox21_113037 [ Show all ]
Inchi Key	KBZOIRJILGZLEJ-LGYYRGKSSA-N
Inchi ID	InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
PubChem CID	644077
ChEMBL	CHEMBL373742
IUPHAR	2168
BindingDB	35667, 50044777
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Kact	2.3 nM	PMID17300166	ChEMBL
Ki	0.125893 nM	PMID9264324	IUPHAR
Ki	0.23 nM	PMID9223568	BindingDB
Ki	0.29 nM	PMID17300166	ChEMBL

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