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GPCR

NameAdenosine receptor A2a
SpeciesRattus norvegicus (Rat)
GeneAdora2a
SynonymA2-AR
A2A receptor
adenosine receptor A2a
RDC8
DiseaseN/A for non-human GPCRs
Length410
Amino acid sequenceMGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
UniProtP30543
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL302
IUPHAR19
DrugBankN/A

Ligand

NameCHEMBL187071
Molecular formulaC22H23F3N8O
IUPAC name2-(furan-2-yl)-7-N-methyl-7-N-[2-[4-(2,4,6-trifluorophenyl)piperazin-1-yl]ethyl]-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
Molecular weight472.476
Hydrogen bond acceptor11
Hydrogen bond donor1
XlogP2.9
SynonymsSCHEMBL5654046
2-Furan-2-yl-N*7*-methyl-N*7*-{2-[4-(2,4,6-trifluoro-phenyl)-piperazin-1-yl]-ethyl}-[1,2,4]triazolo[1,5-c]pyrimidine-5,7-diamine
BDBM50152242
Inchi KeyAWZBLJMDHCKOOF-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H23F3N8O/c1-30(18-13-19-27-21(17-3-2-10-34-17)29-33(19)22(26)28-18)4-5-31-6-8-32(9-7-31)20-15(24)11-14(23)12-16(20)25/h2-3,10-13H,4-9H2,1H3,(H2,26,28)
PubChem CID11351928
ChEMBLCHEMBL187071
IUPHARN/A
BindingDB50152242
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
Ki24.0 nMPMID15341934BindingDB,ChEMBL

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