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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Lysophosphatidic acid receptor 6
Species	Homo sapiens (Human)
Gene	LPAR6
Synonym	Purinergic receptor 5 P2Y5 P2Y purinoceptor 5 P2RY5 oleoyl-L-alpha-lysophosphatidic acid receptor LPA6 receptor LPA-6 LPA receptor 6 RB intron encoded G-protein coupled receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA
UniProt	P43657
Protein Data Bank	N/A
GPCR-HGmod model	P43657
3D structure model	This predicted structure model is from GPCR-EXP P43657.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2331058
IUPHAR	163
DrugBank	N/A

Ligand

Name	CHEMBL2335047
Molecular formula	C22H47O5PS
IUPAC name	dihydroxy-[(2S)-2-methoxy-3-octadecoxypropoxy]-sulfanylidene-lambda5-phosphane
Molecular weight	454.647
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	8.8
Synonyms	BDBM50430010
Inchi Key	JYAROLONGLXUOT-QFIPXVFZSA-N
Inchi ID	InChI=1S/C22H47O5PS/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26-20-22(25-2)21-27-28(23,24)29/h22H,3-21H2,1-2H3,(H2,23,24,29)/t22-/m0/s1
PubChem CID	71720690
ChEMBL	CHEMBL2335047
IUPHAR	N/A
BindingDB	50430010
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	89.13 nM	PMID23395664	ChEMBL
EC50	90.0 nM	PMID23395664	BindingDB,ChEMBL
Intrinsic activity	11.0 -	PMID23395664	ChEMBL

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