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Name | Lysophosphatidic acid receptor 6 |
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Species | Homo sapiens (Human) |
Gene | LPAR6 |
Synonym | Purinergic receptor 5 P2Y5 P2Y purinoceptor 5 P2RY5 oleoyl-L-alpha-lysophosphatidic acid receptor [ Show all ] |
Disease | N/A |
Length | 344 |
Amino acid sequence | MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA |
UniProt | P43657 |
Protein Data Bank | N/A |
GPCR-HGmod model | P43657 |
3D structure model | This predicted structure model is from GPCR-EXP P43657. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2331058 |
IUPHAR | 163 |
DrugBank | N/A |
Name | CHEMBL2335048 |
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Molecular formula | C22H47O5PS |
IUPAC name | dihydroxy-[(2R)-2-methoxy-3-octadecoxypropoxy]-sulfanylidene-lambda5-phosphane |
Molecular weight | 454.647 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 8.8 |
Synonyms | BDBM50430006 |
Inchi Key | JYAROLONGLXUOT-JOCHJYFZSA-N |
Inchi ID | InChI=1S/C22H47O5PS/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26-20-22(25-2)21-27-28(23,24)29/h22H,3-21H2,1-2H3,(H2,23,24,29)/t22-/m1/s1 |
PubChem CID | 71719457 |
ChEMBL | CHEMBL2335048 |
IUPHAR | N/A |
BindingDB | 50430006 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 39.0 nM | PMID23395664 | BindingDB |
EC50 | 104.71 nM | PMID23395664 | ChEMBL |
EC50 | 105.0 nM | PMID23395664 | BindingDB,ChEMBL |
Intrinsic activity | 10.9 - | PMID23395664 | ChEMBL |
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