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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	INDORAMIN
Molecular formula	C22H25N3O
IUPAC name	N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide
Molecular weight	347.462
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	4.1
Synonyms	Benzamide, N-(1-(2-(1H-indol-3-yl)ethyl)-4-piperidinyl)- GTPL501 Indoramina KS-00002WRM N-(1-(2-Indol-3-ylethyl)-4-piperidyl)benzamide Oprea1_130443 SMR000567879 AC1L1PYQ Benzamide, N-[1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl]- D04531 IDI1_016359 Indoramine [INN-French] Maybridge3_004972 N-[1-[2-(1H-indol-3-yl)ethyl]piperidin-4-yl]benzamide PDSP2_001083 WY 21901 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole AF-0013 Baratol CCG-41146 DTXSID7048370 Indoramin [USAN:BAN:INN] Indoraminum [INN-Latin] MolPort-002-914-870 N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide(Indoramin) SCHEMBL49517 Benzamide, N-(1-(2-indol-3-ylethyl)-4-piperidyl)- CHEMBL279516 HMS1445B22 Indoramina [INN-Spanish] L001292 N-(1-[2-(1H-Indol-3-yl)ethyl]-4-piperidinyl)benzamide # PDSP1_001099 SR-01000631243-1 0Z802HMY7H AC1Q5FDP BRN 0494035 INDORAMINN-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide MCULE-9172964530 N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide PDSP2_001407 Wy-21901 3-[2-(4-Benzamido-1-piperidyl)ethyl]indole AJ-08048 BDBM50033113 CHEBI:135470 EINECS 248-041-5 Indoramin [USAN:INN:BAN] JXZZEXZZKAWDSP-UHFFFAOYSA-N N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)benzamide NCGC00165810-01 SCHEMBL49518 Benzamide, N-[1-(2-indol-3-ylethyl)-4-piperidyl]- D02LHR HMS2851P23 Indoramine LS-27034 N-[1-(2-Indol-3-ylethyl)-4-piperidyl]benzamide PDSP1_001423 UNII-0Z802HMY7H 26844-12-2 ACM26844122 AKOS015994528 C22H25N3O DB08950 Indoramin (USAN/INN) Indoraminum MLS001182179 N-{1-[2-(1H-Indol-3-yl)-ethyl]-piperidin-4-yl}-benzamide (Indoramin) S052 ZINC1567 3-[2-(4-Benzamidopiperidino)ethyl]indole [ Show all ]
Inchi Key	JXZZEXZZKAWDSP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)
PubChem CID	33625
ChEMBL	CHEMBL279516
IUPHAR	501
BindingDB	50033113
DrugBank	DB08950
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	11220.2 nM	PubChem BioAssay data set	ChEMBL

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