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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Mus musculus (Mouse)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P12657
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3733
IUPHAR	13
DrugBank	N/A

Ligand

Name	5-propargyloxycarbonyl-1,4,5,6-tetrahydropyrimidine hydrochloride
Molecular formula	C8H11ClN2O2
IUPAC name	prop-2-ynyl 1,4,5,6-tetrahydropyrimidine-5-carboxylate;hydrochloride
Molecular weight	202.638
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	None
Synonyms	LS-134895 Prop-2-ynyl 1,4,5,6-tetrahydropyrimidine-5-carboxylate Hydrochloride MolPort-039-242-812 SCHEMBL2977778 CHEMBL542065 prop-2-yn-1-yl 1,4,5,6-tetrahydropyrimidine-5-carboxylate hydrochloride Z2412196384 AKOS033901465 [ Show all ]
Inchi Key	JWROAMHWGYSSMW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H10N2O2.ClH/c1-2-3-12-8(11)7-4-9-6-10-5-7;/h1,6-7H,3-5H2,(H,9,10);1H
PubChem CID	10176595
ChEMBL	CHEMBL542065
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	33000.0 nM	PMID9111297	ChEMBL
Inhibition	31.5 %	PMID9111297	ChEMBL
Inhibition	68.5 %	PMID9111297	ChEMBL
Ki	2.88 nM	PMID9111297	ChEMBL
Ki	41.7 nM	PMID9111297	ChEMBL
Smax	590.0 %	PMID9111297	ChEMBL

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