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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL193583
Molecular formulaC29H32N4O2
IUPAC name2-[(4-phenoxyphenyl)methylamino]-N-[1-(2-pyrrolidin-1-ylethyl)indol-6-yl]acetamide
Molecular weight468.601
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.3
Synonyms2-(4-Phenoxy-benzylamino)-N-[1-(2-pyrrolidin-1-yl-ethyl)-1H-indol-6-yl]-acetamide
BDBM50167563
Inchi KeyJVDRAQMZKJWZBL-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H32N4O2/c34-29(22-30-21-23-8-12-27(13-9-23)35-26-6-2-1-3-7-26)31-25-11-10-24-14-17-33(28(24)20-25)19-18-32-15-4-5-16-32/h1-3,6-14,17,20,30H,4-5,15-16,18-19,21-22H2,(H,31,34)
PubChem CID44402768
ChEMBLCHEMBL193583
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50299.0 nMPMID15911251ChEMBL

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