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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL85009
Molecular formula	C20H13Cl2N3
IUPAC name	4-[2,4-bis(4-chlorophenyl)-1H-imidazol-5-yl]pyridine
Molecular weight	366.245
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.2
Synonyms	2,4-Bis(4-chlorophenyl)-5-(4-pyridinyl)-1H-imidazole BDBM50104353 SCHEMBL2649730 4-[2,5-Bis-(4-chloro-phenyl)-3H-imidazol-4-yl]-pyridine
Inchi Key	AWHRFPLTQPNOTD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H13Cl2N3/c21-16-5-1-13(2-6-16)18-19(14-9-11-23-12-10-14)25-20(24-18)15-3-7-17(22)8-4-15/h1-12H,(H,24,25)
PubChem CID	10338890
ChEMBL	CHEMBL85009
IUPHAR	N/A
BindingDB	50104353
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	23.0 nM	N/A	BindingDB
IC50	23.01 nM	Med Chem Res, (2013) None:None:1	ChEMBL
IC50	190.0 nM	PMID11549467	BindingDB,ChEMBL
IC50	2200.0 nM	PMID11549467	BindingDB,ChEMBL

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