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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Mus musculus (Mouse)
Gene	Mchr1
Synonym	SLC-1 {ECO:0000303\|PubMed:11159839} MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	Q8JZL2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4730
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL229223
Molecular formula	C29H34ClFN4O2
IUPAC name	3-(3-chloro-4-fluorophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[(2S)-2-(hydroxymethyl)-5-methylpyrrolidin-1-yl]ethyl]urea
Molecular weight	525.065
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.1
Synonyms	3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((2S)-2-(hydroxymethyl)-5-methylpyrrolidin-1-yl)ethyl)urea BDBM50215603
Inchi Key	JSBKWKUNFQUTEC-UCBGLHKLSA-N
Inchi ID	InChI=1S/C29H34ClFN4O2/c1-19-5-7-25(18-36)34(19)11-12-35(28(37)33-23-6-8-27(31)26(30)15-23)24-9-10-29(16-22(29)14-24)21-4-2-3-20(13-21)17-32/h2-4,6,8,13,15,19,22,24-25,36H,5,7,9-12,14,16,18H2,1H3,(H,33,37)/t19?,22?,24-,25+,29-/m1/s1
PubChem CID	44424217
ChEMBL	CHEMBL229223
IUPHAR	N/A
BindingDB	50215603
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	2.0 %	PMID17572094	ChEMBL
Activity	31.0 %	PMID17572094	ChEMBL

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