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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Homo sapiens (Human)
Gene	PTGER1
Synonym	PGE receptor EP1 subtype EP1 receptor prostaglandin E receptor 1 (subtype EP1), 42kDa Prostanoid EP1 receptor EP1 prostanoid receptor PGE2 receptor EP1 subtype [ Show all ]
Disease	Unspecified Thrombosis Pollakiuria Pain
Length	402
Amino acid sequence	MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
UniProt	P34995
Protein Data Bank	N/A
GPCR-HGmod model	P34995
3D structure model	This predicted structure model is from GPCR-EXP P34995.
BioLiP	N/A
Therapeutic Target Database	T15497
ChEMBL	CHEMBL1811
IUPHAR	340
DrugBank	BE0000064

Ligand

Name	CHEMBL265086
Molecular formula	C26H24O5S
IUPAC name	3-[2-(5-methylsulfonyl-2-phenylmethoxyphenyl)cyclopenten-1-yl]benzoic acid
Molecular weight	448.533
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.5
Synonyms	3-{2-[5-methylsulfonyl-2-(benzyloxy)-phenyl]-cyclopent-1-enyl}-benzoic Acid AVURIILTXHUFQX-UHFFFAOYSA-N SCHEMBL5620981
Inchi Key	AVURIILTXHUFQX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H24O5S/c1-32(29,30)21-13-14-25(31-17-18-7-3-2-4-8-18)24(16-21)23-12-6-11-22(23)19-9-5-10-20(15-19)26(27)28/h2-5,7-10,13-16H,6,11-12,17H2,1H3,(H,27,28)
PubChem CID	10216958
ChEMBL	CHEMBL265086
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	79.43 nM	PMID17084082	ChEMBL

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