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Name | G-protein coupled receptor 35 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR35 |
Synonym | G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor |
Disease | N/A |
Length | 309 |
Amino acid sequence | MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA |
UniProt | Q9HC97 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9HC97 |
3D structure model | This predicted structure model is from GPCR-EXP Q9HC97. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1293267 |
IUPHAR | 102 |
DrugBank | BE0005562 |
Name | CHEMBL2431118 |
---|---|
Molecular formula | C25H32N4O3 |
IUPAC name | 6,7-dimethoxy-4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-(2-methylpropyl)quinazoline |
Molecular weight | 436.556 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 5.1 |
Synonyms | BDBM50440767 MLS-0471511.0001 SCHEMBL15819842 |
Inchi Key | JMACYYSITUBWPB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H32N4O3/c1-17(2)14-24-26-19-16-23(32-5)22(31-4)15-18(19)25(27-24)29-12-10-28(11-13-29)20-8-6-7-9-21(20)30-3/h6-9,15-17H,10-14H2,1-5H3 |
PubChem CID | 56593282 |
ChEMBL | CHEMBL2431118 |
IUPHAR | N/A |
BindingDB | 50440767 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <40000.0 nM | PMID24611085 | BindingDB,ChEMBL |
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