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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Follicle-stimulating hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Fshr
Synonym	Follitropin receptor FSH receptor FSH-R LGR1
Disease	N/A for non-human GPCRs
Length	692
Amino acid sequence	MALLLVSLLAFLGTGSGCHHWLCHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELNLSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTLMEASLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPSYGKGSDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRVTNSYVLVPLNHSSQN
UniProt	P20395
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4288
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL192135
Molecular formula	C33H32N2O2
IUPAC name	N-(1-acetyl-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-4-phenylbenzamide
Molecular weight	488.631
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.8
Synonyms	AUNHRXZPYDMERZ-UHFFFAOYSA-N 1-Acetyl-4-phenyl-6-(4-phenylbenzoyl)amino-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline BDBM50162936 Biphenyl-4-carboxylic acid (1-acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-6-yl)-amide SCHEMBL1323199
Inchi Key	AUNHRXZPYDMERZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H32N2O2/c1-23(36)35-30-20-19-28(21-29(30)33(4,22-32(35,2)3)27-13-9-6-10-14-27)34-31(37)26-17-15-25(16-18-26)24-11-7-5-8-12-24/h5-21H,22H2,1-4H3,(H,34,37)
PubChem CID	11260332
ChEMBL	CHEMBL192135
IUPHAR	N/A
BindingDB	50162936
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	540.0 nM	PMID15771412	BindingDB,ChEMBL

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