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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL594302
Molecular formulaC15H15ClN2OS
IUPAC name(2S)-2-(4-chlorophenyl)-3-cyclopropyl-N-(1,3-thiazol-2-yl)propanamide
Molecular weight306.808
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.2
SynonymsBDBM50305924
(S)-2-(4-chlorophenyl)-3-cyclopropyl-N-(thiazol-2-yl)propanamide
Inchi KeyIXLDGZYBMMNXQT-ZDUSSCGKSA-N
Inchi IDInChI=1S/C15H15ClN2OS/c16-12-5-3-11(4-6-12)13(9-10-1-2-10)14(19)18-15-17-7-8-20-15/h3-8,10,13H,1-2,9H2,(H,17,18,19)/t13-/m0/s1
PubChem CID46226338
ChEMBLCHEMBL594302
IUPHARN/A
BindingDB50305924
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy72.0 %PMID20005104ChEMBL
IC508800.0 nMPMID20005104BindingDB,ChEMBL

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