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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Sus scrofa (Pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	291
Amino acid sequence	AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProt	P79400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL63790
Molecular formula	C21H20N4O2S
IUPAC name	8-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Molecular weight	392.477
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.4
Synonyms	BDBM50407790
Inchi Key	IURWVMMKDXJLTR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20N4O2S/c1-2-17-20(22-16-5-11-28-21(16)25(17)6-1)24-9-7-23(8-10-24)13-15-3-4-18-19(12-15)27-14-26-18/h1-6,11-12H,7-10,13-14H2
PubChem CID	11794853
ChEMBL	CHEMBL63790
IUPHAR	N/A
BindingDB	50407790
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	36307.8 nM	PMID8642566	BindingDB,ChEMBL

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