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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	1-(4-methylpiperazin-1-yl)-4-phenylphthalazine
Molecular formula	C19H20N4
IUPAC name	1-(4-methylpiperazin-1-yl)-4-phenylphthalazine
Molecular weight	304.397
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.0
Synonyms	1-(4-Methylpiperazino)-4-phenylphthalazine HMS1421G20 AC1O47GZ MolPort-000-224-571 1-(4-Methyl-piperazin-1-yl)-4-phenyl-phthalazine; hydrochloride CHEMBL1191986 ZINC126549 23100-01-8 IFLab1_003320 AKOS001055637 Oprea1_625306 CHEMBL543160 MCULE-8354288847 BDBM50062450 Z31193861 [ Show all ]
Inchi Key	ACBUSPOAUFLRNN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N4/c1-22-11-13-23(14-12-22)19-17-10-6-5-9-16(17)18(20-21-19)15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
PubChem CID	6401141
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50062450
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	13000.0 nM	PMID9464362	BindingDB

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