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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Bos taurus (Bovine)
Gene	DRD2
Synonym	Dopamine D2 receptor
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P20288
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3998
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	ADTN
Molecular formula	C10H13NO2
IUPAC name	6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight	179.219
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.4
Synonyms	6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol CHEMBL26736 HMS1792C05 KBioGR_002511 NCGC00015291-04 PDSP1_000820 2-aminotetralin-6,7-diol 6-azanyl-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide Biomol-NT_000003 cMAP_000069 KB-199024 Lopac0_000415 NCGC00162147-01 SCHEMBL3126243 53463-78-8 6,7-Dihydroxy-3-chromanamine AC1L1FAH CCG-204507 FT-0645288 KBio2_007647 NCGC00015291-02 NCGC00162147-04 SR-01000075362-6 2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol AKOS006328808 cid_11957526 HMS1990C05 KBioSS_002519 NCGC00015291-05 PDSP2_000476 (+)-ADTN 2-aminotetralin-6,7-diol;hydrobromide BPBio1_001127 CTK4J8115 KBio2_002511 LS-175452 NCGC00162147-02 SMR001254097 2,3-Naphthalenediol, 6-amino-5,6,7,8-tetrahydro- 6,7-Adtn 6-Amino-5,6,7,8-tetrahydro-2,3-naphthalenediol AC1Q79PY GTPL932 KBio3_002989 NCGC00015291-03 PDSP1_000478 2-Amino-6,7-dihydroxytetralin 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide BDBM81195 cid_3153 HMS3403C05 L000081 NCGC00015291-06 PDSP2_000807 (+)-ADTN (aminotetralin-6,7-diol) 463A788 BSPBio_001023 D0X2NO KBio2_005079 MLS002172466 NCGC00162147-03 SR-01000075362 2,3-Naphthalenediol,6-amino-5,6,7,8-tetrahydro- 6,7-Dihydroxy-2-aminotetralin [ Show all ]
Inchi Key	ASXGAOFCKGHGMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
PubChem CID	3153
ChEMBL	CHEMBL26736
IUPHAR	932
BindingDB	81195
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
K Bind	0.21 uM	PMID2875183	ChEMBL
Kb	210.0 nM	PMID4068005	ChEMBL
Ki	120.0 nM	PMID995128	BindingDB

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