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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1A
Species	Rattus norvegicus (Rat)
Gene	Htr1a
Synonym	5-HT1A receptor 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5-HT1A ADRB2RL1 ADRBRL1 5-HT-1A Gpcr18 Serotonin receptor 1A [ Show all ]
Disease	N/A for non-human GPCRs
Length	422
Amino acid sequence	MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProt	P19327
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL273
IUPHAR	1
DrugBank	N/A

Ligand

Name	N-Methylserotonin
Molecular formula	C11H14N2O
IUPAC name	3-[2-(methylamino)ethyl]-1H-indol-5-ol
Molecular weight	190.246
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.7
Synonyms	1H-Indol-5-ol, 3-[2-(methylamino)ethyl]- Lopac0_000743 NCGC00015648-01 PDSP1_001694 3-[2-(methylamino)ethyl]-1H-indol-5-ol ASUSBMNYRHGZIG-UHFFFAOYSA-N DTXSID40150396 N-Methyl Serotonin NCGC00015648-04 PDSP2_001679 1134-01-6 5-Hydroxy-N\|O-methyltryptamine CCG-204828 J-002959 N-Methylserotonin; 3-[2-(methylamino)ethyl]-1H-indol-5-ol; Lopac-M-1514 Norbufotenin 1H-Indol-5-ol,3-[2-(methylamino)ethyl]- AC1L457X CHEMBL277362 LS-191851 NCGC00015648-02 PDSP1_001696 3-[2-(Methylamino)ethyl]indol-5-ol BDBM50024202 FCH831385 N-Methyl-5-hydroxytryptamine NCGC00142416-01 SCHEMBL1127784 1H-Indol-5-ol, 3-(2-(methylamino)ethyl)- 5-OH-ME-Nw Tryptamine CHEBI:48294 Lopac-M-1514 N-Methylserotonine N\|O-Methylserotonin 3-(2-(methylamino)ethyl)-1H-indol-5-ol AKOS006227847 CTK4A8294 MCULE-2918354234 NCGC00015648-03 PDSP2_001677 5-Hydroxy-N-methyltryptamine C06212 FT-0672197 NCGC00142416-02 ZINC1592424 [ Show all ]
Inchi Key	ASUSBMNYRHGZIG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H14N2O/c1-12-5-4-8-7-13-11-3-2-9(14)6-10(8)11/h2-3,6-7,12-14H,4-5H2,1H3
PubChem CID	150885
ChEMBL	CHEMBL277362
IUPHAR	N/A
BindingDB	50024202
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.898 nM	PMID8568799	ChEMBL
Ki	5.0 nM	PMID3543362	BindingDB,ChEMBL

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