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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Delta-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRD1
Synonym	D-OR-1 DOR opioid receptor OP1 DOP DOPr DOR-1 Delta receptor [ Show all ]
Disease	Cough Overactive bladder disorder Bladder disease Moderate-to-severe pain Diarrhea-predominant IBS Major depressive disorder Urinary incontinence Rheumatoid arthritis Premature ejaculation Pain Acute migraine Ischemic heart diseases Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease Alcohol use disorders Anxiety disorder [ Show all ]
Length	372
Amino acid sequence	MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
UniProt	P41143
Protein Data Bank	4rwd, 4rwa, 4n6h
GPCR-HGmod model	P41143
3D structure model	This structure is from PDB ID 4rwd.
BioLiP	BL0303696,BL0303697, BL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700
Therapeutic Target Database	T58992
ChEMBL	CHEMBL236
IUPHAR	317
DrugBank	BE0000420

Ligand

Name	Hydromorphine
Molecular formula	C17H21NO3
IUPAC name	3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight	287.359
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.8
Synonyms	L000955 NSC117865 CAS_509-60-4 Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)- Paramorphan .alpha.-Dihydromorphine DIHYDROBROMORPHINE Morphine, dihydro- AC1L6SLS Morphinan-3, 4,5-epoxy-17-methyl-, (5.alpha.,6.alpha.)- NSC_273032 (5.alpha.,6.alpha.)-4,5-Epoxy-17-methylmorphinan-3,6-diol Morphinan-3,6.alpha.-diol, 4,5.alpha.-epoxy-17-methyl- SCHEMBL6123637 6.alpha.-Hydromorphol Dihydromorfin IJVCSMSMFSCRME-UHFFFAOYSA-N NSC-117865 BDBM86518 Morphinan-3, 4,5.alpha.-epoxy-17-methyl- Paramorfan CHEMBL608541 FT-0667072 Morphine, 7,8-dihydro- WLN: T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ FQ JQ P1 [ Show all ]
Inchi Key	IJVCSMSMFSCRME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3
PubChem CID	273032
ChEMBL	CHEMBL608541
IUPHAR	N/A
BindingDB	86518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	203.4 nM	PMID9686407	PDSP

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