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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL423473
Molecular formulaC15H17IN2O2
IUPAC name3-(1H-imidazol-5-yl)propyl 3-(4-iodophenyl)propanoate
Molecular weight384.217
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.1
SynonymsZINC13747354
3-(4-Iodo-phenyl)-propionic acid 3-(1H-imidazol-4-yl)-propyl ester
BDBM50050168
SCHEMBL8104619
4-Iodobenzenepropionic acid 3-(1H-imidazol-4-yl)propyl ester
Inchi KeyASQUEGTXNJDXRT-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H17IN2O2/c16-13-6-3-12(4-7-13)5-8-15(19)20-9-1-2-14-10-17-11-18-14/h3-4,6-7,10-11H,1-2,5,8-9H2,(H,17,18)
PubChem CID10620015
ChEMBLCHEMBL423473
IUPHARN/A
BindingDB50050168
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
-Log KB3.6 -PMID8632428ChEMBL

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