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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL1922916
Molecular formula	C34H37ClN2O4
IUPAC name	3-[[4-[2-[1-(4-tert-butylphenyl)-5-chloroindole-2-carbonyl]pentyl]benzoyl]amino]propanoic acid
Molecular weight	573.13
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	8.1
Synonyms	BDBM50358815
Inchi Key	ASNLEFCYIJEHPP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C34H37ClN2O4/c1-5-6-24(19-22-7-9-23(10-8-22)33(41)36-18-17-31(38)39)32(40)30-21-25-20-27(35)13-16-29(25)37(30)28-14-11-26(12-15-28)34(2,3)4/h7-16,20-21,24H,5-6,17-19H2,1-4H3,(H,36,41)(H,38,39)
PubChem CID	57396138
ChEMBL	CHEMBL1922916
IUPHAR	N/A
BindingDB	50358815
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	52.0 nM	PMID22030028	BindingDB,ChEMBL

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