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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL435445
Molecular formula	C26H27ClN2O3
IUPAC name	3-chloro-N-[(E)-[2,3-dimethyl-4-[(4-propan-2-ylphenyl)methoxy]phenyl]methylideneamino]-4-hydroxybenzamide
Molecular weight	450.963
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	6.4
Synonyms	BDBM50110085 SCHEMBL9072077 3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-2,3-dimethyl-phenyl]-meth-(E)-ylidene]-hydrazide
Inchi Key	ASGOMALKAXVFRD-CCVNUDIWSA-N
Inchi ID	InChI=1S/C26H27ClN2O3/c1-16(2)20-7-5-19(6-8-20)15-32-25-12-10-22(17(3)18(25)4)14-28-29-26(31)21-9-11-24(30)23(27)13-21/h5-14,16,30H,15H2,1-4H3,(H,29,31)/b28-14+
PubChem CID	44373463
ChEMBL	CHEMBL435445
IUPHAR	N/A
BindingDB	50110085
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	740.0 nM	PMID11844695	BindingDB,ChEMBL

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