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GLASS

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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	cid_664130
Molecular formula	C21H25N3O5S
IUPAC name	4-(2,4-dimethyl-1,3-thiazole-5-carbonyl)-5-(5-methylfuran-2-yl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
Molecular weight	431.507
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	1.8
Synonyms	BDBM37666 3-[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]-2-(5-methylfuran-2-yl)-1-(2-morpholin-4-ylethyl)-4-oxidanyl-2H-pyrrol-5-one 4-(2,4-dimethylthiazole-5-carbonyl)-3-hydroxy-5-(5-methyl-2-furyl)-1-(2-morpholinoethyl)-3-pyrrolin-2-one 3-[(2,4-dimethyl-5-thiazolyl)-oxomethyl]-4-hydroxy-2-(5-methyl-2-furanyl)-1-[2-(4-morpholinyl)ethyl]-2H-pyrrol-5-one
Inchi Key	ASCJKQMJZOBPAI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H25N3O5S/c1-12-4-5-15(29-12)17-16(18(25)20-13(2)22-14(3)30-20)19(26)21(27)24(17)7-6-23-8-10-28-11-9-23/h4-5,16-17H,6-11H2,1-3H3
PubChem CID	91896319
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37666
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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