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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	BURIMAMIDE
Molecular formula	C9H16N4S
IUPAC name	1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
Molecular weight	212.315
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.4
Synonyms	34970-69-9 DTXSID00188519 PDSP2_001081 LS-187654 TN5A4OD2TV 1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea NCGC00167790-01 AC1MHUYH HXRBAVXGYZUSED-UHFFFAOYSA-N SCHEMBL7860369 C07448 N-(4-imidazol-4-ylbutyl)-N'-methylthiourea UNII-TN5A4OD2TV CHEMBL12160 PDSP1_001097 BDBM22888 LS-187038 Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- 1-[4-(1H-imidazol-5-yl)butyl]-3-methyl-thiourea CHEBI:3221 N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea ZINC13831238 [ Show all ]
Inchi Key	HXRBAVXGYZUSED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14)
PubChem CID	3032915
ChEMBL	CHEMBL12160
IUPHAR	N/A
BindingDB	22888
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
KB	7.8e-06 -	PMID1967317	ChEMBL
Ki	316228.0 nM	PMID7783156	ChEMBL

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