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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Mus musculus (Mouse)
Gene	Chrm3
Synonym	cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 cholinergic receptor M3 receptor M3R Mm3 mAChR HM4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	Q9ERZ3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Oxotremorine 1
Molecular formula	C11H18N2O
IUPAC name	N-methyl-N-(4-pyrrolidin-1-ylbut-2-ynyl)acetamide
Molecular weight	194.278
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	0.3
Synonyms	N-methyl-N-(4-pyrrolidino-2-butynyl)acetamide CHEMBL11081 LS-10001 Acetamide, N-methyl-N-[4-(1-pyrrolidinyl)-2-butyn-1-yl]- N-Methyl-N-(4-pyrrolidin-1-yl-but-2-ynyl)-acetamide UH-5 BRN 4247641 N-Methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]acetamide # AC1L2EPH DTXSID90191870 N-(4-pyrrolidino-2-butynyl) -N-methylacetamide SCHEMBL11726909 Acetamide, N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]- N-methyl-N-(4-pyrrolidin-1-ylbut-2-ynyl)acetamide UH5;N-Methyl-N-(4-pyrrolidin-1-yl-but-2-ynyl)-acetamide 3854-05-5 Oxo 1 ACETAMIDE, N-METHYL-N-(4-(1-PYRROLIDINYL)-2-BUTYNYL)- HWYHDWGGACRVEH-UHFFFAOYSA-N N-Methyl-N-(4-pyrrolidin-1'-ylbut-2-ynyl)acetamide UH 5 BDBM50009300 [ Show all ]
Inchi Key	HWYHDWGGACRVEH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H18N2O/c1-11(14)12(2)7-3-4-8-13-9-5-6-10-13/h5-10H2,1-2H3
PubChem CID	19716
ChEMBL	CHEMBL11081
IUPHAR	N/A
BindingDB	50009300
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
PI turnover	41.6 -	PMID1848294	ChEMBL

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