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GLASS

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GPCR

Name	D(3) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD3
Synonym	dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor
Disease	Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders Cocaine addiction Schizophrenia Drug abuse [ Show all ]
Length	400
Amino acid sequence	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
UniProt	P35462
Protein Data Bank	3pbl
GPCR-HGmod model	P35462
3D structure model	This structure is from PDB ID 3pbl.
BioLiP	BL0191566, BL0191567
Therapeutic Target Database	T02551
ChEMBL	CHEMBL234
IUPHAR	216
DrugBank	BE0000581

Ligand

Name	TERTATOLOL
Molecular formula	C16H25NO2S
IUPAC name	1-(tert-butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol
Molecular weight	295.441
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.7
Synonyms	Tertatolol (INN) 1-(tert-Butylamino)-3-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)propan-2-ol 2-Propanol, 1-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)- 83688-85-1 (hydrochloride) CHEMBL434200 FT-0675301 Racemic teraterol TERTATOLOL(-) ( inverted exclamation markA)-Tertatolol 1-(tert-butylamino)-3-[(3,4-dihydro-2h-1-benzothiopyran-8-yl)oxy]propan-2-ol 2-propanol, 1-((3,40dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)- API0007011 D07182 KB-216025 S-2395 tert-butyl[3-(3,4-dihydro-2H-1-benzothiopyran-8-yloxy)-2-hydroxypropyl]amine Tertatololum [Latin] 1-[(3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol CHEBI:135244 dl-Tertatolol LS-177775 Tertatolol [BAN:INN] 1-(tert-butylamino)-3-(3,4-dihydro-2H-thiochromen-8-yloxy)propan-2-ol 2-Propanol, 1-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-, (+-)- AC1L1WMU CS-7407 GTPL571 Racemic Tertatolol SCHEMBL49634 tertatolol, (+-)-isomer (+-)-1-((3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-2-propanol 1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2-ol 34784-64-0 BDBM50280934 DL-8-(2'-hydroxy-3'-t-butylaminopropyloxy)thiochroman.HCl L001170 1-((3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-2-propanol 1-[[(3,4-Dihydro-2H-1-benzothiopyran)-8-yl]oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol 83688-84-0 EINECS 280-519-9 rac Tertatolol Tertatolol [INN:BAN] 1-(tert-butylamino)-3-thiochroman-8-yloxypropan-2-ol 2-Propanol, 1-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-,(+-)- ACM34784640 D03SFU HY-U00356 S 2395 SE-2395 Tertatololum (+-)-1-(tert-Butylamino)-3-(thiochroman-8-yloxy)-2-propanol 1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2-ol(TERtatolol) C16H25NO2S dl-Tertatalol LS-122112 [ Show all ]
Inchi Key	HTWFXPCUFWKXOP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3
PubChem CID	36920
ChEMBL	CHEMBL434200
IUPHAR	571
BindingDB	50280934
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9067310	PDSP,BindingDB

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