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Name | Somatostatin receptor type 3 |
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Species | Homo sapiens (Human) |
Gene | SSTR3 |
Synonym | SSR-28 SS3R SS3-R SS-3-R SRIF1C [ Show all ] |
Disease | N/A |
Length | 418 |
Amino acid sequence | MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL |
UniProt | P32745 |
Protein Data Bank | N/A |
GPCR-HGmod model | P32745 |
3D structure model | This predicted structure model is from GPCR-EXP P32745. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2028 |
IUPHAR | 357 |
DrugBank | BE0003529 |
Name | BDBM82467 |
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Molecular formula | C73H99N15O18 |
IUPAC name | (14R,20S,23R,26R,29R,32R)-2,17-bis(4-aminobutyl)-5-(2-amino-2-oxoethyl)-8,11-dibenzyl-20,26-bis[(1S)-1-hydroxyethyl]-29-(hydroxymethyl)-23-[(4-hydroxyphenyl)methyl]-14-(1H-indol-3-ylmethyl)-3,6,9,12,15,18,21,24,27,30,38-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecazacyclooctatriacontane-32-carboxylic acid |
Molecular weight | 1474.68 |
Hydrogen bond acceptor | 20 |
Hydrogen bond donor | 20 |
XlogP | -0.8 |
Synonyms | 2-Deamino-L-Abu(1)-L-Lys-L-Asp(NH2)-L-Phe-L-Phe-L-Trp-L-Lys-L-Thr-L-Tyr-L-Thr-L-Ser-L-Abu(1)-OH |
Inchi Key | HTEPNQQGQXAYEW-RDULDWFGSA-N |
Inchi ID | InChI=1S/C73H99N15O18/c1-41(90)61-71(103)85-55(36-45-28-30-47(92)31-29-45)69(101)88-62(42(2)91)72(104)86-58(40-89)70(102)80-52(73(105)106)26-10-5-11-27-60(94)78-50(24-14-16-32-74)63(95)84-57(38-59(76)93)68(100)82-53(34-43-18-6-3-7-19-43)65(97)81-54(35-44-20-8-4-9-21-44)66(98)83-56(37-46-39-77-49-23-13-12-22-48(46)49)67(99)79-51(64(96)87-61)25-15-17-33-75/h3-4,6-9,12-13,18-23,28-31,39,41-42,50-58,61-62,77,89-92H,5,10-11,14-17,24-27,32-38,40,74-75H2,1-2H3,(H2,76,93)(H,78,94)(H,79,99)(H,80,102)(H,81,97)(H,82,100)(H,83,98)(H,84,95)(H,85,103)(H,86,104)(H,87,96)(H,88,101)(H,105,106)/t41-,42-,50?,51?,52+,53?,54?,55+,56+,57?,58+,61-,62+/m0/s1 |
PubChem CID | 91898461 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 82467 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.39 nM | PMID8769372 | BindingDB |
Ki | 0.52 nM | PMID10598788, PMID9650799 | BindingDB |
Ki | 0.6 nM | PMID8521788 | BindingDB |
Ki | 0.7 nM | PMID10598788 | BindingDB |
Ki | 1.51 nM | PMID10598788, PMID9650799 | BindingDB |
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