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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Delta-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprd1
Synonym	opioid receptor OP1 DOR-1 DOR DOPr DOP delta receptor D-OR-1 Opioid receptor A [ Show all ]
Disease	N/A for non-human GPCRs
Length	372
Amino acid sequence	MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProt	P33533
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL269
IUPHAR	317
DrugBank	N/A

Ligand

Name	CHEMBL143800
Molecular formula	C23H25NO3
IUPAC name	(8E)-5-(3-hydroxyphenyl)-8-[(4-methoxyphenyl)methylidene]-2-methyl-2-azabicyclo[3.3.1]nonan-7-one
Molecular weight	363.457
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.6
Synonyms	BDBM50029786 5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-methyl-2-aza-bicyclo[3.3.1]nonan-7-one
Inchi Key	ABVYYLMONIBFMA-UDWIEESQSA-N
Inchi ID	InChI=1S/C23H25NO3/c1-24-11-10-23(17-4-3-5-18(25)13-17)14-21(24)20(22(26)15-23)12-16-6-8-19(27-2)9-7-16/h3-9,12-13,21,25H,10-11,14-15H2,1-2H3/b20-12+
PubChem CID	10713756
ChEMBL	CHEMBL143800
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<500.0 nM	PMID7490727	ChEMBL
Ki	7.1 nM	PMID7490727	ChEMBL
Ki	127.0 nM	PMID7490727	ChEMBL

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