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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Mu-type opioid receptor
Species	Mus musculus (Mouse)
Gene	Oprm1
Synonym	opioid receptor, mu 1 opioid receptor OP3 Mu receptor MOR-1 MOPr MOP M-OR-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P42866
Protein Data Bank	4dkl, 5c1m, 6dde, 6ddf
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4dkl.
BioLiP	BL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2858
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL93614
Molecular formula	C22H29NO2
IUPAC name	3-[(3R,4R)-1-(2-hydroxy-3-phenylpropyl)-3,4-dimethylpiperidin-4-yl]phenol
Molecular weight	339.479
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	4.5
Synonyms	3-[(3R,4R)-1-(2-Hydroxy-3-phenylpropyl)-3,4-dimethyl-4-piperidinyl]phenol BDBM50045766 3-[1-(2-Hydroxy-3-phenyl-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol
Inchi Key	APTJADCVFISWLZ-QNGGVGCWSA-N
Inchi ID	InChI=1S/C22H29NO2/c1-17-15-23(16-21(25)13-18-7-4-3-5-8-18)12-11-22(17,2)19-9-6-10-20(24)14-19/h3-10,14,17,21,24-25H,11-13,15-16H2,1-2H3/t17-,21?,22+/m0/s1
PubChem CID	9997334
ChEMBL	CHEMBL93614
IUPHAR	N/A
BindingDB	50045766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
AD50	0.27 mg kg-1	PMID8410998	ChEMBL

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