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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | CHEMBL315836 |
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Molecular formula | C21H15ClFN3 |
IUPAC name | 4-[2-(4-chlorophenyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-2-methylpyridine |
Molecular weight | 363.82 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | 4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-2-methyl-pyridine BDBM50218790 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-(2-methyl-4-pyridyl)-1H-imidazole BDBM50104380 |
Inchi Key | APKKXGAJMPHCEP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H15ClFN3/c1-13-12-16(10-11-24-13)20-19(14-4-8-18(23)9-5-14)25-21(26-20)15-2-6-17(22)7-3-15/h2-12H,1H3,(H,25,26) |
PubChem CID | 44319257 |
ChEMBL | CHEMBL315836 |
IUPHAR | N/A |
BindingDB | 50104380 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 50.0 nM | , Med Chem Res, (2013) None:None:1 | BindingDB,ChEMBL |
Inhibition | 38.0 % | PMID11549467 | ChEMBL |
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