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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin E2 receptor EP4 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger4
Synonym	EP2 EP4 receptor PGE receptor EP4 subtype PGE2 receptor EP4 subtype Prostanoid EP4 receptor
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProt	P43114
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4086
IUPHAR	343
DrugBank	N/A

Ligand

Name	CHEMBL425409
Molecular formula	C22H30N2O4
IUPAC name	7-[(2S)-2-[(3R)-4-(3-cyanophenyl)-3-hydroxybutyl]-5-oxopyrrolidin-1-yl]heptanoic acid
Molecular weight	386.492
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.7
Synonyms	7-((S)-2-((R)-4-(3-cyanophenyl)-3-hydroxybutyl)-5-oxopyrrolidin-1-yl)heptanoic acid BDBM50181275 SCHEMBL4992757
Inchi Key	GZYGDVPAEYSBBK-VQTJNVASSA-N
Inchi ID	InChI=1S/C22H30N2O4/c23-16-18-7-5-6-17(14-18)15-20(25)11-9-19-10-12-21(26)24(19)13-4-2-1-3-8-22(27)28/h5-7,14,19-20,25H,1-4,8-13,15H2,(H,27,28)/t19-,20+/m0/s1
PubChem CID	44409923
ChEMBL	CHEMBL425409
IUPHAR	N/A
BindingDB	50181275
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	104.0 %	PMID16442794	ChEMBL
EC50	96.0 nM	PMID16442794	BindingDB,ChEMBL
IC50	388.0 nM	PMID16442794	BindingDB,ChEMBL

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