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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL161710
Molecular formulaC21H28N2O
IUPAC nameN-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]aniline
Molecular weight324.468
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.1
SynonymsN-Phenyl-3-[3-(piperidinomethyl)phenoxy]-1-propanamine
SKF95299
Inchi KeyABQYWTUZKZNLKQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H28N2O/c1-3-10-20(11-4-1)22-13-8-16-24-21-12-7-9-19(17-21)18-23-14-5-2-6-15-23/h1,3-4,7,9-12,17,22H,2,5-6,8,13-16,18H2
PubChem CID10245719
ChEMBLCHEMBL161710
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
-Log KB5.7 -PMID2894467ChEMBL

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