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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh2
Synonym	gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
UniProt	P25102
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4654
IUPHAR	263
DrugBank	N/A

Ligand

Name	CHEMBL17740
Molecular formula	C12H15N3
IUPAC name	N-benzyl-2-(1H-imidazol-5-yl)ethanamine
Molecular weight	201.273
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.3
Synonyms	ZINC34349451 benzylhistamine 7728-61-2 GVOCXQUIZNWEMU-UHFFFAOYSA-N SCHEMBL14415974 BDBM50419043 1H-Imidazole-5-ethanamine, N-(phenylmethyl)- AKOS014319525 N-Benzyl-1H-imidazole-4-(ethanamine) SCHEMBL4605920 Benzyl-[2-(1H-imidazol-4-yl)-ethyl]-amine N-benzyl-2-(1H-imidazol-5-yl)ethanamine AKOS022987924 [ Show all ]
Inchi Key	GVOCXQUIZNWEMU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H15N3/c1-2-4-11(5-3-1)8-13-7-6-12-9-14-10-15-12/h1-5,9-10,13H,6-8H2,(H,14,15)
PubChem CID	14712103
ChEMBL	CHEMBL17740
IUPHAR	N/A
BindingDB	50419043
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Agonist activity	0.5 -	PMID6128418	ChEMBL

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