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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	Q9QYN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4124
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL420892
Molecular formula	C14H16N2O3
IUPAC name	ethyl 4-[2-(1H-imidazol-5-yl)ethoxy]benzoate
Molecular weight	260.293
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.2
Synonyms	4-[2-(1H-Imidazol-4-yl)ethoxy]benzoic acid ethyl ester ABPLWFSNNTVIKC-UHFFFAOYSA-N 4-[2-(4-Ethoxycarbonylphenoxy)ethyl]-1H-imidazole BDBM50053281 4-[2-(1H-Imidazol-4-yl)-ethoxy]-benzoic acid ethyl ester SCHEMBL7974811 [ Show all ]
Inchi Key	ABPLWFSNNTVIKC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2O3/c1-2-18-14(17)11-3-5-13(6-4-11)19-8-7-12-9-15-10-16-12/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
PubChem CID	10848915
ChEMBL	CHEMBL420892
IUPHAR	N/A
BindingDB	50053281
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6.0 nM	PMID8809168	BindingDB,ChEMBL

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