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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	UNM000003612901
Molecular formula	C20H19NO2S
IUPAC name	4-(3-methylphenyl)-7-thiophen-2-yl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
Molecular weight	337.437
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.7
Synonyms	4-(3-methylphenyl)-7-thien-2-yl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione BAS 14393591 MCULE-8533975758 CHEMBL1559320 STK406650 4-(3-methylphenyl)-7-(2-thienyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione AKOS000664770 HMS1497B15 4-(3-methylphenyl)-7-thiophen-2-yl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione BDBM40455 MolPort-000-915-530 7-Thiophen-2-yl-4-m-tolyl-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione ChemDiv3_008485 4-(3-methylphenyl)-7-(thiophen-2-yl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione AKOS022032725 IDI1_026395 4-(m-tolyl)-7-(2-thienyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-quinone ST50318226 AC1O5RPP cid_6462587 [ Show all ]
Inchi Key	AODLUYOBLGFFGE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19NO2S/c1-12-4-2-5-13(8-12)15-11-19(23)21-16-9-14(10-17(22)20(15)16)18-6-3-7-24-18/h2-8,14-15H,9-11H2,1H3,(H,21,23)
PubChem CID	6462587
ChEMBL	CHEMBL1559320
IUPHAR	N/A
BindingDB	40455
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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