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GLASS

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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	135450-94-1
Molecular formula	C12H14N6OS
IUPAC name	N-[[6-[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]pyridin-2-yl]methyl]acetamide
Molecular weight	290.345
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-0.5
Synonyms	BDBM50036755 SCHEMBL9296782 4-(6-(ACETAMIDOMETHYL)(PYRIDIN-2-YL))-2-GUANIDINOTHIAZOLE CTK4B9825 4-Apgt N-[6-(2-Guanidino-thiazol-4-yl)-pyridin-2-ylmethyl]-acetamide; hydrochloride AKOS030547480 CHEMBL1196182 4-(6-(Acetamidomethyl)pyridin-2-yl)-2-guanidinothiazole L004994 AOCMLOWDFAEKJE-UHFFFAOYSA-N N-[[6-[2-[(Diaminomethylene)amino]-4-thiazolyl]-2-pyridinyl]methyl]acetamide CHEMBL556048 4-(6-acetylaminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole N-((6-(2-((Aminoiminomethyl)amino)-4-thiazolyl)-2-pyridinyl)methyl)acetamide Acetamide, N-((6-(2-((aminoiminomethyl)amino)-4-thiazolyl)-2-pyridinyl)methyl)- [ Show all ]
Inchi Key	AOCMLOWDFAEKJE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H14N6OS/c1-7(19)15-5-8-3-2-4-9(16-8)10-6-20-12(17-10)18-11(13)14/h2-4,6H,5H2,1H3,(H,15,19)(H4,13,14,17,18)
PubChem CID	10446940
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50036755
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1300.0 nM	PMID7904648	BindingDB

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