1q3a A 2.1 BS06 NGH A 1 S179 L180 A181 H217 E218 H227 P237 S241 S75 L76 A77 H113 E114 H123 P133 S137 H217 E218 H221 H227 H113 E114 H117 H123 3.4.24.22 0004222,0006508,0008237,0008270,0031012 P09238 15095982 480 MPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDNYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSLAQFRLSQDDVNGIQSLYG 1q3a B 2.1 BS06 NGH B 1 S179 L180 A181 H217 E218 H221 H227 P237 Y239 S76 L77 A78 H114 E115 H118 H124 P134 Y136 H217 E218 H221 H227 H114 E115 H118 H124 3.4.24.22 0004222,0006508,0008237,0008270,0031012 P09238 15095982 479 GMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDNYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYG 1q3a C 2.1 BS06 NGH C 1 S179 L180 A181 H217 E218 H221 H227 L238 Y239 S74 L75 A76 H112 E113 H116 H122 L133 Y134 H217 E218 H221 H227 H112 E113 H116 H122 3.4.24.22 0004222,0006508,0008237,0008270,0031012 P09238 15095982 481 PKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDNYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSLAQFRLSQDDVNGIQSLYG 1rmz A 1.34 BS06 NGH A 1 I180 L181 A182 T215 H218 E219 H222 H228 P238 T239 Y240 I76 L77 A78 T111 H114 E115 H118 H124 P134 T135 Y136 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.00, Kd=10nM Ki=4.3nM P39900 15809432 269 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 1ycm A -1.00 BS06 NGH A 1 L181 A182 T215 H218 E219 P238 T239 Y240 L77 A78 T111 H114 E115 P134 T135 Y136 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.00, Kd=10nM Ki=4.3nM P39900 15809432 269 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 1z3j A -1.00 BS06 NGH A 1 G179 I180 L181 A182 L214 T215 H218 E219 H222 P238 T239 Y240 G75 I76 L77 A78 L110 T111 H114 E115 H118 P134 T135 Y136 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.00, Kd=10nM Ki=4.3nM P39900 15809432 269 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 2jnp A -1.00 BS05 NGH A 1 L164 A165 H166 H201 E202 H205 H211 L77 A78 H79 H114 E115 H118 H124 H201 E202 H205 H211 H114 E115 H118 H124 3.4.24.17 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=6.89, Ki=130nM Ki=132nM, IC50=6500nM P08254 17710450 253 GIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGP 2jsd A -1.00 BS05 NGH A 1 T188 L189 A190 H226 E227 H230 H236 P246 Y248 T76 L77 A78 H114 E115 H118 H124 P134 Y136 H226 E227 H230 H236 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=7.77, Kd=17nM O60882 17869250 277 GEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGP 4dpe B 1.96 BS07 NGH B 1 V163 L164 A165 H201 E202 H205 H211 Y223 V75 L76 A77 H113 E114 H117 H123 Y135 H201 E202 H205 H211 H113 E114 H117 H123 3.4.24.17 0004222,0006508,0008237,0008270,0031012 Ki=132nM, IC50=6500nM P08254 23660647 313 IPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 4g9l B 1.88 BS06 NGH B 1 V163 L164 A165 V198 H201 E202 H205 H211 Y223 V75 L76 A77 V110 H113 E114 H117 H123 Y135 H201 E202 H205 H211 H113 E114 H117 H123 3.4.24.17 0004222,0006508,0008237,0008270,0031012 Ki=132nM, IC50=6500nM P08254 23660647 307 IPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 4ja1 B 1.96 BS06 NGH B 1 V163 L164 A165 H201 E202 H205 H211 V75 L76 A77 H113 E114 H117 H123 H201 E202 H205 H211 H113 E114 H117 H123 3.4.24.17 0004222,0006508,0008237,0008270,0031012 Ki=132nM, IC50=6500nM P08254 23660647 306 IPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPET 5lab A 1.34 BS06 NGH A 1 I180 A182 H218 E219 H222 H228 P238 Y240 I76 A78 H114 E115 H118 H124 P134 Y136 H218 E219 H222 H228 H114 E115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 Ki=4.3nM P39900 306 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG