3wtq A 2.10 BS01 III C 1 I238 K242 I256 L259 P412 E416 V417 I58 K62 I76 L79 P232 E236 V237 P13053 KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN 3wtq A 2.10 BS02 YS9 A 1 Y143 V230 S233 I267 M268 R270 S271 S274 W282 C284 H301 L305 H393 Y397 F418 Y21 V50 S53 I87 M88 R90 S91 S94 W102 C104 H121 L125 H213 Y217 F238 P13053 KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN 3wxv A 2.90 BS01 ZN A 1 H191 H337 H341 H103 H247 H251 Q96A54 GSEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDT 3wxw A 2.40 BS01 ZN A 1 H202 H348 H352 H103 H247 H251 Q86V24 EFEGRWRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFLCLGIFYMFRISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKLDYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRGVRAGVFLGLGLSGIIPTLHYVISEGFLKAATIIGWLMLMASLYITGAALYAARIPERFFPGKCDIWFHSHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCSEED 4d4z A 1.70 BS01 FE A 1 H56 H89 E90 H207 H61 H94 E95 H212 1.14.99.29 GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHE 4d4z A 1.70 BS02 FE A 2 H56 E90 H207 H240 E241 H61 E95 H212 H245 E246 1.14.99.29 GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHE 4d4z A 1.70 BS03 GOL A 1 H89 E90 E93 H207 E208 Y211 E241 H94 E95 E98 H212 E213 Y216 E246 1.14.99.29 GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHE 4d4z B 1.70 BS01 FE B 1 H89 E90 H207 H94 E95 H212 1.14.99.29 Q9BU89 GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETG 4d4z B 1.70 BS02 FE B 2 H56 H207 H240 E241 H61 H212 H245 E246 1.14.99.29 Q9BU89 GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETG 4d50 A 1.70 BS02 FE A 2 H56 H240 E241 H61 H245 E246 1.14.99.29 Q9BU89 GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQAFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEALGAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYLSVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALAEGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEALGAIARPACLAALQAHADDPERVVRESCEVALDMYEHETG 4n54 A 2.05 BS01 NAI A 1 V11 G12 L13 G14 R15 L16 S38 V39 V40 E43 V75 S76 P77 S78 F80 H81 E98 K99 M128 F170 D182 H186 F287 F295 V8 G9 L10 G11 R12 L13 S35 V36 V37 E40 V72 S73 P74 S75 F77 H78 E95 K96 M125 F167 D179 H183 F284 F292 1.1.1.- B3W8L4 KTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELDWAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLDIEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAGMASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELETGAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIRPTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQVAS 4n54 A 2.05 BS02 2H3 A 1 R15 K99 D159 D182 M183 H186 R241 Y247 F287 R12 K96 D156 D179 M180 H183 R238 Y244 F284 1.1.1.- B3W8L4 KTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELDWAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLDIEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAGMASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELETGAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIRPTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQVAS 4n54 B 2.05 BS01 NAI B 1 V11 G12 L13 G14 R15 L16 S38 V39 V40 E43 V75 S76 P77 S78 F80 H81 E98 K99 M128 F170 H186 F287 V8 G9 L10 G11 R12 L13 S35 V36 V37 E40 V72 S73 P74 S75 F77 H78 E95 K96 M125 F167 H183 F284 1.1.1.- B3W8L4 KTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELDWAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLDIEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAGMASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELETGAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIRPTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQVAS 4n54 C 2.05 BS01 NAI C 1 V11 G12 L13 G14 R15 L16 S38 V39 E43 V75 S76 P77 F80 H81 E98 K99 M128 H186 V8 G9 L10 G11 R12 L13 S35 V36 E40 V72 S73 P74 F77 H78 E95 K96 M125 H183 1.1.1.- B3W8L4 KTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELDWAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLDIEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAGMASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELETGAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIRPTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQVAS 4n54 D 2.05 BS01 NAI D 1 L13 G14 R15 L16 S38 V39 E43 P77 F80 E98 K99 M128 F170 H186 F287 L10 G11 R12 L13 S35 V36 E40 P74 F77 E95 K96 M125 F167 H183 F284 1.1.1.- B3W8L4 KTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELDWAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLDIEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAGMASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELETGAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIRPTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQVAS 4n54 D 2.05 BS02 2H3 D 1 K99 D159 D182 M183 H186 Y247 F287 K96 D156 D179 M180 H183 Y244 F284 1.1.1.- B3W8L4 KTIKIGIVGLGRLGKIHATNIATKIQHAKLQAATSVVPAELDWAKKELGVEEVFEDFDDMVQHADIDAVFIVSPSGFHLQQIESALNAGKHVFSEKPIGLDIEAIEHTQQVIAQHANLKFQLGFMRRFDDSYRYAKQLVDQGKIGDITLIRSYSIDPAAGMASFVKFATSANSGGLFLDMSIHDIDVIRWFTGKEIDKVWAIGLNRAYPVLDKAGELETGAALMQLEDKTMAILVAGRNAAHGYHVETEIIGTKGMLRIAQVPEKNLVTVMNEEGIIRPTSQNFPERFAQAFLSEEQAFVNSILNNQDVGITAEDGLQGTKAALALQEAFEKNDIVQVAS 4ofb A 3.05 BS01 III B 1 S1655 G1656 L1657 T1658 P1659 F1662 N1678 E1698 R1699 V1741 N1774 M1775 R1835 E1836 D1840 S7 G8 L9 T10 P11 F14 N30 E50 R51 V93 N126 M127 R185 E186 D190 P38398 25654734 RMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIP 4olf A 2.90 BS01 ANP A 1 R390 E392 I400 R401 T402 F405 W407 Q475 A476 A477 T478 T512 R514 R136 E138 I146 R147 T148 F151 W153 Q221 A222 A223 T224 T258 R260 6.1.1.15 Q8I5R7 ILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQAFFNKEIKKLNVENSYFPLFVTKNKLEKIEGFSPEVAWVTKYGDSNLPEEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPFIRTREFLWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKFGGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQYVHQTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFYKTTDENAIHSYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPKDLQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLDDSIVQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLLSGAMKPLCIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY 4olf A 2.90 BS02 HFG A 1 F335 E338 V339 P358 T359 E361 R390 W407 H411 F454 T478 H480 S508 W509 G510 F81 E84 V85 P104 T105 E107 R136 W153 H157 F200 T224 H226 S254 W255 G256 6.1.1.15 Q8I5R7 ILGITSKKIENFSDWYTQVIVKSELIEYYDISGCYILRPAAYYIWECVQAFFNKEIKKLNVENSYFPLFVTKNKLEKIEGFSPEVAWVTKYGDSNLPEEIAIRPTSETIMYSVFPKWIRSYRDLPLKLNQWNTVVRWEFKQPTPFIRTREFLWQEGHTAHKNEEEAVKLVFDILDLYRRWYEEYLAVPIIKGIKSEGEKFGGANFTSTAEAFISENGRAIQAATSHYLGTNFAKMFKIEFEDENEVKQYVHQTSWGCTTRSIGIMIMTHGDDKGLVLPPNVSKYKVVIVPIFYKTTDENAIHSYCKDIEKILKNAQINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPKDLQNNSCVIVRRDNNEKCNVKKESVLLETQQMLVDIHKNLFLKAKKKLDDSIVQVTSFSEVMNALNKKKMVLAPWCEDIATEEEIKKETQRLLSGAMKPLCIPLDQPPMPPNMKCFWSGKPAKRWCLFGRSY 4omj A 1.60 BS01 2TX A 1 L106 A108 L111 L120 L121 I151 Y153 C155 L158 H162 A167 A170 Y171 F174 L175 L189 F198 A201 Y202 I205 I217 L106 A108 L111 L120 L121 I151 Y153 C155 L158 H162 A167 A170 Y171 F174 L175 L189 F198 A201 Y202 I205 I217 O76054 MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQV 4omk A 1.75 BS01 SQL A 1 L84 L106 A108 L111 L120 L121 K124 Y153 C155 L158 H162 L163 A167 V168 A170 Y171 F174 L175 L189 F198 A201 Y202 I205 L209 T213 I217 L84 L106 A108 L111 L120 L121 K124 Y153 C155 L158 H162 L163 A167 V168 A170 Y171 F174 L175 L189 F198 A201 Y202 I205 L209 T213 I217 O76054 MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQV 4p14 A 2.00 BS03 ADE A 1 Y12 N14 T15 D16 R228 Y12 N14 T15 D16 R227 P55915 ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNSHETNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN 4p14 A 2.00 BS04 DBB A 1 S113 L115 N124 A125 L126 V179 H180 S113 L115 N123 A124 L125 V178 H179 P55915 ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNSHETNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN 4pvg A 2.40 BS01 2WT A 1 C459 S460 R465 Q506 Q510 C198 S199 R204 Q245 Q249 3.1.3.48 Q06124 FETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL 4pvx F 2.18 BS03 YS1 F 1 F99 A102 D103 M106 D107 R112 T167 E168 Q171 K200 T201 D243 K257 F92 A95 D96 M99 D100 R105 T160 E161 Q164 K193 T194 D236 K250 2.5.1.10,2.5.1.1 P14324 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4py2 A 2.15 BS01 43E A 1 A11 I12 Y14 D51 H53 G54 F213 M227 Y228 V229 W230 D232 A233 Y237 I265 F268 H269 A9 I10 Y12 D49 H51 G52 F211 M225 Y226 V227 W228 D230 A231 Y235 I263 F266 H267 6.1.1.10 Q2YQ76 REKYYITTAIAYPNGKPHIGHAYELIATDAMARFQRLNGMDVYFLTGTDEHGIKMLQSARKEGITPRDLADRNTSAFRRMAEVLNSSNDDYIRTSEERHYKASQAIWQAMVANGDIYKGGYAGWYSVRDEAYYGEEETEVRADGVRYGPQGTPVEWVEEESYFFRLSAYQDKLLDLYENNPGFIMPAERRNEIVSFVKSGLKDLSISRTTFDWGIPVPGDEKHVMYVWVDALTNYITALGYPDTTDERWAYWPANAHIIGKDISRFHAVYWPAFLMSAQLPLPKRVFAHGFLFNRIDPFELVERYGLDQLRYFLMREVPFGQDGSYSHEAIVNRTNADLANDLGNLAQRSLSMIAKNCEGKVPQPGAFSEADKAILDQADAALETARKAMDDQALHLALGAIFAVVAEANRYFAGQEPWALRKTDPARMGTVLYVTAEVLRRVGIMVQPFIPQSAEKLLDILAVPADKRQFADVLASPLAGGTDLPAPQPVFPRY 4q2v A 2.20 BS01 0XE A 1 R213 E220 R258 C259 R209 E216 R254 C255 3.2.2.22 P02879 QYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPP 4q4e A 1.90 BS02 BB2 A 1 N259 M260 G261 A262 E264 Y275 H297 E298 H301 E320 D327 Y376 Y381 R783 R825 N255 M256 G257 A258 E260 Y271 H293 E294 H297 E316 D323 Y372 Y377 R779 R821 3.4.11.2 P04825 25644575 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4q4i A 2.31 BS01 III C 1 Q119 E121 M260 G261 A262 M263 E264 K274 Y275 H297 E298 H301 K319 E320 Y376 Y381 R783 R825 Q115 E117 M256 G257 A258 M259 E260 K270 Y271 H293 E294 H297 K315 E316 Y372 Y377 R779 R821 3.4.11.2 P04825 25644575 PQAKYRHDYRAPDYQITDIDLTFDLDAQKTVVTAVSQAVRHGASDAPLRLNGEDLKLVSVHINDEPWTAWKEEEGALVISNLPERFTLKIINEISPAANTALEGLYQSGDALCTQCEAEGFRHITYYLDRPDVLARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRGNLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHEYFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPDMVIEMNNFYTLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNVDLSHFRRWYSQSGTPIVTVKDDYNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALLCEFSAPVKLEYKWSDQQLTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEKIDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHEDIAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQATSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDLNSRNPQVASRLIEPLIRLKRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKALA 4q50 A 3.07 BS01 OHT A 1 L346 A350 D351 E353 W383 L384 L387 L391 R394 F404 M421 I424 L428 L525 V533 P535 L28 A32 D33 E35 W65 L66 L69 L73 R76 F85 M99 I102 L106 L195 V198 P200 P03372 ALSLTADQMVSALLDAEPPILYSMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPKLLFAPNLLLDRNQGKGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSVVPLYGLLLEMLD 4q50 B 3.07 BS01 OHT B 1 M343 L346 A350 D351 E353 W383 L384 L391 R394 F404 M421 I424 F425 L428 L525 M26 L29 A33 D34 E36 W66 L67 L74 R77 F87 M102 I105 F106 L109 L196 P03372 ALSLTADQMVSALLDAEPPILYSEMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMLYGLLLEMLD 4q50 C 3.07 BS01 OHT C 1 L349 A350 D351 E353 W383 L384 L387 L391 R394 F404 M421 I424 L428 G521 L525 V533 L34 A35 D36 E38 W68 L69 L72 L76 R79 F89 M104 I107 L111 G200 L204 V207 P03372 LALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTSSTSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSVVPLYGLLLEMLDA 4q50 D 3.07 BS01 OHT D 1 M343 L346 A350 D351 E353 W383 L391 R394 F404 M421 L428 G521 L525 M29 L32 A36 D37 E39 W69 L77 R80 F90 M107 L114 G199 L203 P03372 LALSLTADQMVSALLDAEPPILYSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMLYGLLLEMLD 4q50 E 3.07 BS01 OHT E 1 M343 T347 A350 D351 E353 L384 L387 R394 F404 M421 I424 F425 G521 L525 M30 T34 A37 D38 E40 L71 L74 R81 F91 M107 I110 F111 G201 L205 P03372 LALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMLYGLLLEMLD 4q50 F 3.07 BS01 OHT F 1 M343 A350 D351 E353 W383 L384 R394 F404 M421 I424 L428 G521 L525 M33 A40 D41 E43 W73 L74 R84 F94 M111 I114 L118 G204 L208 P03372 ALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSLYGLLLEMLD 4q50 G 3.07 BS01 OHT G 1 A350 D351 E353 L354 W383 L384 L387 M388 R394 F404 M421 L428 L525 A36 D37 E39 L40 W69 L70 L73 M74 R80 F90 M107 L114 L204 P03372 ALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMPLYGLLLEMLDA 4q50 H 3.07 BS01 OHT H 1 L346 T347 A350 D351 E353 W383 L387 L391 R394 F404 M421 I424 L428 L525 P535 L32 T33 A36 D37 E39 W69 L73 L77 R80 F90 M107 I110 L114 L205 P207 P03372 ALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYPLYGLLLEMLDA 4qiy A 1.30 BS02 WWX A 1 N62 N67 I91 Q92 H94 H96 H119 V121 F131 V135 L141 L198 T199 T200 P202 N59 N64 I88 Q89 H91 H93 H116 V118 F127 V131 L137 L194 T195 T196 P198 4.2.1.1 P00918 25758852 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4qiz A 1.55 BS02 WWX A 1 S64 H66 N69 Q94 H96 H98 H121 F133 A137 L200 T201 V202 P204 S59 H61 N64 Q89 H91 H93 H116 F128 A132 L195 T196 V197 P199 4.2.1.1 Q8N1Q1 25758852 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 4qiz B 1.55 BS02 WWX B 1 S64 N69 Q94 H96 H98 H121 V123 F133 A137 L143 L200 T201 V202 P204 S59 N64 Q89 H91 H93 H116 V118 F128 A132 L138 L195 T196 V197 P199 4.2.1.1 Q8N1Q1 25758852 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 4qj0 A 1.55 BS02 WWX A 1 W4 N64 S67 T88 Q89 H91 H93 H117 V119 A129 L139 V141 L197 T198 T199 P200 P201 W2 N62 S65 T86 Q87 H89 H91 H115 V117 A127 L137 V139 L195 T196 T197 P198 P199 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 4qj0 B 1.55 BS02 WWX B 1 W4 N64 H66 T88 H91 H93 H117 V119 A129 S130 S133 L139 L197 T198 T199 P201 W2 N62 H64 T86 H89 H91 H115 V117 A127 S128 S131 L137 L195 T196 T197 P199 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 4qj0 C 1.55 BS02 WWX C 1 W4 N64 S67 T88 Q89 H91 H93 H117 V119 A129 S133 L139 V141 L197 T198 T199 P200 P201 W208 W2 N62 S65 T86 Q87 H89 H91 H115 V117 A127 S131 L137 V139 L195 T196 T197 P198 P199 W206 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 4qj0 D 1.55 BS02 WWX D 1 N64 S67 H91 H93 H117 V119 A129 S130 S133 L139 V141 L197 T198 T199 P200 P201 W208 N62 S65 H89 H91 H115 V117 A127 S128 S131 L137 V139 L195 T196 T197 P198 P199 W206 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 4qjm A 1.75 BS02 V1F A 1 N62 H64 N67 I91 Q92 H94 H96 H119 V121 F131 L198 T199 T200 P201 P202 W209 N59 H61 N64 I88 Q89 H91 H93 H116 V118 F127 L194 T195 T196 P197 P198 W205 4.2.1.1 P00918 25758852 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4qjo A 1.80 BS02 V1F A 1 N64 Q89 H91 H93 E104 H117 A129 V141 L197 T198 T199 P200 P201 N62 Q87 H89 H91 E102 H115 A127 V139 L195 T196 T197 P198 P199 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 4qjo B 1.80 BS02 V1F B 1 N64 Q89 H91 H93 H117 V119 A129 S130 S133 L197 T198 T199 P200 P201 W208 N62 Q87 H89 H91 H115 V117 A127 S128 S131 L195 T196 T197 P198 P199 W206 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFS 4qjp B 1.62 BS02 V1F B 1 W7 S64 H66 N69 Q94 H96 H98 H121 V123 F133 A137 L200 T201 V202 P204 W2 S59 H61 N64 Q89 H91 H93 H116 V118 F128 A132 L195 T196 V197 P199 4.2.1.1 Q8N1Q1 25758852 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 4qjp A 1.62 BS02 V1F A 1 W7 H66 N69 Q94 H96 H98 H121 V123 F133 A137 V145 L200 T201 V202 P204 W211 W2 H61 N64 Q89 H91 H93 H116 V118 F128 A132 V140 L195 T196 V197 P199 W206 4.2.1.1 Q8N1Q1 25758852 SWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRASFH 4qjw A 1.55 BS02 WWO A 1 W4 N64 Q89 H91 H93 E104 H117 V119 A129 S130 S133 V141 L197 T198 T199 P200 W2 N62 Q87 H89 H91 E102 H115 V117 A127 S128 S131 V139 L195 T196 T197 P198 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 4qjw B 1.55 BS02 WWO B 1 N64 Q89 H91 H93 H117 V119 A129 S130 S133 L197 T198 T199 N62 Q87 H89 H91 H115 V117 A127 S128 S131 L195 T196 T197 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 4qjw C 1.55 BS02 WWO C 1 N64 Q89 H91 H93 H117 V119 A129 S133 L197 T198 T199 P200 N62 Q87 H89 H91 H115 V117 A127 S131 L195 T196 T197 P198 4.2.1.1 O43570 25758852 KWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQ 4qpd A 2.10 BS01 THG A 1 C86 Q88 F89 I90 I95 I104 G115 A116 D138 G140 L141 D142 Y200 I203 K205 C86 Q88 F89 I90 I95 I104 G115 A116 D138 G140 L141 D142 Y200 I203 K205 1.5.1.6 E3NZ06 MKIAVIGQSLFGQEVYKELKNEGHMIVGVFTIPDKDGKVDPLAIEAEKDGVPVFKFPRWRLKGKAITEVVDQYKAVGAELNVLPFCSQFIPMEVIDHPKHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTVFWADDGLDTGPILLQRECDVEPNDNVNSIYKRFLFPEGVKGMVEAVRLIATGKAPRIKQPEEGATYECIQKKENSKIDWNQPAEAIHNWIRGNDRVPGAWAEIDGKSVSFYGSTLLENDHFSSNGQPLEIPGASRAALVTKNGLVLFGNDGKMLLVKNLQFEDGKMIPGSQYFK 4qpd B 2.10 BS01 THG B 1 S257 N258 G259 S268 R269 L272 F281 G282 G285 S257 N258 G259 S268 R269 L272 F281 G282 G285 1.5.1.6 E3NZ06 MKIAVIGQSLFGQEVYKELKNEGHMIVGVFTIPDKDGKVDPLAIEAEKDGVPVFKFPRWRLKGKAITEVVDQYKAVGAELNVLPFCSQFIPMEVIDHPKHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTVFWADDGLDTGPILLQRECDVEPNDNVNSIYKRFLFPEGVKGMVEAVRLIATGKAPRIKQPEEGATYECIQKKENSKIDWNQPAEAIHNWIRGNDRVPGAWAEIDGKSVSFYGSTLLENDHFSSNGQPLEIPGASRAALVTKNGLVLFGNDGKMLLVKNLQFEDGKMIPGSQYFK 4qtl A 1.80 BS02 WWO A 1 N62 N67 Q92 H94 H96 H119 V121 F131 V143 L198 T199 T200 W209 N59 N64 Q89 H91 H93 H116 V118 F127 V139 L194 T195 T196 W205 4.2.1.1 P00918 25758852 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4r0m B 2.45 BS01 FA5 B 1 H226 W272 A304 G305 E306 Q307 A333 F334 G335 M336 T337 G342 L363 D421 I432 I531 K533 H220 W266 A298 G299 E300 Q301 A327 F328 G329 M330 T331 G336 L357 D415 I426 I525 K527 A8YJW1 SLGGQLEDNWRTLSEVLETATKHNNHGITYIRNDATEYFQSYQDLYQDALVILNGLEQKGIKLGHKVILQIAKNQDFIPALWACFLGGIIPVPLTVAPSYDLENSAVKKLENVWKILDNPLILSDSELITEIEKLGTYSHLEGWQVISVNELRKAPSKIEQLPILDPQDAALLLFTSGSTGMPKGVILTHHNILSMTAGTVVMNHFTQQEVTLNWMPLDHVGAIVFLGIMAVDLACDQIHVPMELVLRQPLQWLELIQKHQVSISWSPNFAFSLINQQAEELKHVSYNLSSMKFLVNAGEQVSVKTIRLFLEILEKHQLQERAIKPAFGMTESCSGITWSAGLSKNELTEENSFVSLGKPIPGATIRIVDQENNPLPEREIGRLQIQGNSVTKGYYNNNELNQEVFQEGWFTTGDLGYLSKGELFITGREKQEIIINGVNYFAHELETTIEELEGVKVSYTAAFAVFDQSRETDLLIITFSPESEQFEQGIKVVRKIRSHVTQKFGIAPAYVIPLERNLVPKTSIGKVQKSKLKKDFEQGLFSSRIQEIDQYLAK 4r0m A 2.45 BS01 FA5 A 1 H226 G228 W272 A304 G305 E306 Q307 A333 G335 M336 T337 S341 G342 L363 D421 I432 R435 I531 K533 H222 G224 W268 A300 G301 E302 Q303 A329 G331 M332 T333 S337 G338 L359 D417 I428 R431 I527 K529 A8YJW1 SISLGGQLEDNWRTLSEVLETATKHNNHGITYIRNDATEYFQSYQDLYQDALVILNGLEQKGIKLGHKVILQIAKNQDFIPALWACFLGGIIPVPLTVAPSYDLENSAVKKLENVWKILDNPLILSDSELITEIEKLGTYSHLEGWQVISVNELRKAPSKIEQLPILDPQDAALLLFTSGSTGMPKGVILTHHNILSMTAGTVVMNHFTQQEVTLNWMPLDHVGAIVFLGIMAVDLACDQIHVPMELVLRQPLQWLELIQKHQVSISWSPNFAFSLINQQAEELKHVSYNLSSMKFLVNAGEQVSVKTIRLFLEILEKHQLQERAIKPAFGMTESCSGITWSAGLSKNELTEENSFVSLGKPIPGATIRIVDQENNPLPEREIGRLQIQGNSVTKGYYNNNELNQEVFQEGWFTTGDLGYLSKGELFITGREKQEIIINGVNYFAHELETTIEELEGVKVSYTAAFAVFDQSRETDLLIITFSPESEQFEQGIKVVRKIRSHVTQKFGIAPAYVIPLERNLVPKTSIGKVQKSKLKKDFEQGLFSSRIQEIDQYLAKERQKNQTLPQSENERQIAAVWSEVLQLTSVGLEDNFFELGGHSIHLIRVQNELEKLFNRQLSLAEMFKNPTVATLARFLS 4r4u A 2.20 BS01 COA A 1 V34 V39 F64 L65 R66 P67 G68 I101 F102 Q225 T228 R283 H285 V30 V35 F60 L61 R62 P63 G64 I97 F98 Q217 T220 R275 H277 Q8D151 25849407 SQALEKLLDLLDLEKIEEGIFRGQSEDLQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSSKPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFPEKVREKFIGPQPIEMRPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLH 4r4u C 2.20 BS01 COA D 1 R82 G84 N85 S86 F87 R81 G83 N84 S85 F86 Q8D151 25849407 SQALEKLLDLLDLEKIEEGIFRGQSEDLGLRQVFGGQVVGQAIYAAKQTVPAERTVHSFHSYFLRPGDSSKPIIYDVETLRDGNSFSARRVSAIQNGKPIFYMTASFQSQEEGFEHQNTMPDVPPPEGLMSETDIARQFSGPQPIEMRPVKFHNPLQGSVEEPNRYVWFRANGKMPDDLRVHQYLLGYASDFNFLPTALQPHGIGFLEPGMQIATIDHSMWFHRPFRLDDWLLYAVESTSASGARGFVRGQIYNREGVLVASTVQEGVIRLH 4rek A 0.74 BS01 FAD A 1 I16 G17 T18 G19 Y20 G21 L39 E40 M41 G42 L96 Y107 V108 G109 R110 G111 G114 G115 S116 V118 N119 G120 G121 M122 I218 H248 Q249 V250 G288 A289 G290 Y446 H447 D474 G475 N485 P486 F487 I490 I8 G9 T10 G11 Y12 G13 L31 E32 M33 G34 L88 Y99 V100 G101 R102 G103 G106 G107 S108 V110 N111 G112 G113 M114 I210 H240 Q241 V242 G280 A281 G282 Y438 H439 D466 G467 N477 P478 F479 I482 1.1.3.6,5.3.3.1 P12676 GYVPAVVIGTGYGAAVSALRLGEAGVQTLMLEMGQLWNQPGPDGNIFCGMLNPDKRSSWFKNRTEAPLGSFLWLDVVNRNIDPYAGVLDRVNYDQMSVYVGRGVGGGSLVNGGMAVEPKRSYFEEILPRVDSSEMYDRYFPRANSMLRVNHIDTKWFEDTEWYKFARVSREQAGKAGLGTVFVPNVYDFGYMQREAAGEVPKSALATEVIYGNNHGKQSLDKTYLAAALGTGKVTIQTLHQVKTIRQTKDGGYALTVEQKDTDGKLLATKEISCRYLFLGAGSLGSTELLVRARDTGTLPNLNSEVGAGWGPNGNIMTARANHMWNPTGAHQSSIPALGIDAWDNSDSSVFAEIAPMPAGLETWVSLYLAITKNPQRGTFVYDAATDRAKLNWTRDQNAPAVNAAKALFDRINKANGTIYRYDLFGTQLKAFADDFCYHPLGGCVLGKATDDYGRVAGYKNLYVTDGSLIPGSVGVNPFVTITALAERNVERIIKQDV 4rfc A 1.65 BS02 3O1 A 1 H94 H96 H119 L198 T199 T200 P202 W209 H91 H93 H116 L194 T195 T196 P198 W205 4.2.1.1 P00918 25358036 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4rfd A 1.63 BS04 BCT A 1 D242 W244 D239 W241 4.2.1.1 P00918 25358036 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4rpx A 1.90 BS03 NUC T 1 H34 S229 K230 G231 E232 T233 K234 R258 Y271 K280 R283 A284 L287 T292 I293 N294 E295 Y296 H25 S220 K221 G222 E223 T224 K225 R249 Y262 K271 R274 A275 L278 T283 I284 N285 E286 Y287 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rpy A 1.90 BS02 NUC P 1 S104 G105 I106 G107 P108 S109 A110 G179 R183 D190 D192 R254 D256 Y271 F272 T273 G274 D276 N279 S95 G96 I97 G98 P99 S100 A101 G170 R174 D181 D183 R245 D247 Y262 F263 T264 G265 D267 N270 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rpz A 2.19 BS02 NUC P 1 V103 S104 G105 I106 G107 P108 S109 A110 R183 D190 D192 M236 R254 D256 Y271 F272 T273 G274 S275 D276 N279 V94 S95 G96 I97 G98 P99 S100 A101 R174 D181 D183 M227 R245 D247 Y262 F263 T264 G265 S266 D267 N270 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq0 A 2.20 BS02 NUC P 1 V103 G105 I106 G107 P108 S109 A110 R183 D190 D192 M236 R254 D256 Y271 F272 T273 G274 D276 N279 V95 G97 I98 G99 P100 S101 A102 R175 D182 D184 M228 R246 D248 Y263 F264 T265 G266 D268 N271 2.7.7.7,4.2.99.- P06746 25825995 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq0 A 2.20 BS05 DCP A 1 D124 K127 D116 K119 2.7.7.7,4.2.99.- P06746 25825995 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq1 A 2.70 BS01 NUC D 1 K35 P63 G64 V65 G66 K68 I69 K26 P54 G55 V56 G57 K59 I60 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDR 4rq1 A 2.70 BS02 NUC P 1 V103 S104 G105 I106 G107 P108 S109 A110 D190 R254 Y271 F272 G274 D276 N279 V94 S95 G96 I97 G98 P99 S100 A101 D181 R245 Y262 F263 G265 D267 N270 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDR 4rq2 A 2.20 BS02 NUC P 1 S104 G105 G107 P108 S109 A110 R183 D190 D192 R254 D256 Y271 F272 T273 G274 D276 N279 S96 G97 G99 P100 S101 A102 R175 D182 D184 R246 D248 Y263 F264 T265 G266 D268 N271 2.7.7.7,4.2.99.- P06746 25825995 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSEHHHHHH 4rq2 A 2.20 BS07 MN A 3 H337 H339 H329 H331 2.7.7.7,4.2.99.- P06746 25825995 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSEHHHHHH 4rq2 A 2.20 BS08 MN A 4 K48 H336 H338 K40 H328 H330 2.7.7.7,4.2.99.- P06746 25825995 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSEHHHHHH 4rq4 A 2.10 BS01 NUC D 1 H34 K35 A38 Y39 G64 G66 K68 I69 H25 K26 A29 Y30 G55 G57 K59 I60 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq4 A 2.10 BS07 PPV A 1 R149 G179 S180 R183 G189 D190 R140 G170 S171 R174 G180 D181 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq5 A 2.32 BS02 NUC P 1 V103 S104 G105 I106 G107 P108 S109 A110 R183 D190 D192 M236 R254 D256 Y271 F272 G274 D276 N279 V94 S95 G96 I97 G98 P99 S100 A101 R174 D181 D183 M227 R245 D247 Y262 F263 G265 D267 N270 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq6 A 2.25 BS01 NUC D 1 H34 K35 A38 Y39 G64 G66 T67 K68 I69 H25 K26 A29 Y30 G55 G57 T58 K59 I60 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE 4rq7 A 2.00 BS02 NUC P 1 V103 S104 G105 I106 G107 P108 S109 A110 D190 R254 Y271 D276 V94 S95 G96 I97 G98 P99 S100 A101 D181 R245 Y262 D267 2.7.7.7,4.2.99.- P06746 25825995 TLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRS 4rq8 A 2.00 BS06 MN A 2 E9 H337 H339 E1 H329 H331 2.7.7.7,4.2.99.- P06746 25825995 ETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSEHHHHHH 4rsc A 1.80 BS02 A3V A 1 F61 F103 T129 V134 T147 E148 N194 I259 Y338 F59 F101 T109 V114 T127 E128 N174 I234 Y309 3.1.1.64 Q28175 SQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFEVTDNALVNIYPVGEDYYACTETNFITKVNPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSGANYMDCFESNETMGVWLHIADKKRKKYINNKYRTSPFNLFHHINTYEDHEFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS 4rse A 2.39 BS02 A6V A 1 F61 F103 T129 V134 T147 E148 N194 H241 I259 Y275 F279 Y338 F60 F102 T111 V116 T129 E130 N176 H218 I236 Y252 F256 Y315 3.1.1.64 Q28175 SSQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPEVTDNALVNIYPVGEDYYACTETNFITKVNPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYINNKYRTSPFNLFHHINTYEDHEFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS 4rse B 2.39 BS02 A6V B 1 F61 F103 T129 V134 T147 E148 T149 N175 N194 I259 Y275 F279 Y338 F60 F102 T111 V116 T129 E130 T131 N157 N176 I236 Y252 F256 Y315 3.1.1.64 Q28175 SSQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPEVTDNALVNIYPVGEDYYACTETNFITKVNPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYINNKYRTSPFNLFHHINTYEDHEFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYGGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS 4rtj A 1.99 BS01 NUC G 1 Y92 R95 R124 N126 L127 N132 P134 T198 Y90 R93 R122 N124 L125 N130 P132 T187 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSTNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRRKKVDELLALYKP 4rtj A 1.99 BS02 SFG A 1 W10 A11 G12 K14 P34 F35 V36 A38 S40 D54 I55 S164 Y165 D181 P183 W8 A9 G10 K12 P32 F33 V34 A36 S38 D52 I53 S162 Y163 D179 P181 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSTNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRRKKVDELLALYKP 4rtk A 1.96 BS01 NUC G 1 R95 R124 N126 L127 N132 P134 R93 R122 N124 L125 N130 P132 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVKVDELLALYKP 4rtk A 1.96 BS02 SAH A 1 W10 A11 P34 F35 V36 G37 A38 G39 S40 D54 I55 S164 Y165 D181 P183 W8 A9 P32 F33 V34 G35 A36 G37 S38 D52 I53 S162 Y163 D179 P181 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVKVDELLALYKP 4rtl A 2.19 BS01 NUC G 1 R95 R124 N126 L127 N132 R93 R122 N124 L125 N130 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSANSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRSIRKKVDELLALYKPG 4rtl A 2.19 BS02 SFG A 1 W10 A11 G12 P34 F35 V36 A38 D54 I55 S164 Y165 D181 W8 A9 G10 P32 F33 V34 A36 D52 I53 S162 Y163 D179 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSANSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRSIRKKVDELLALYKPG 4rtm A 2.50 BS02 SAM A 1 W10 A11 G12 P34 F35 V36 G37 A38 S40 D54 I55 S164 Y165 D181 P183 F201 W8 A9 G10 P32 F33 V34 G35 A36 S38 D52 I53 S162 Y163 D179 P181 F189 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKKVDELLALYKP 4rtn A 2.59 BS02 SAH A 1 W10 A11 G12 F35 D54 I55 S164 Y165 D181 P182 P183 Y184 F201 W8 A9 G10 F33 D52 I53 S162 Y163 D179 P180 P181 Y182 F188 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRSKKVDELLALYKP 4rto A 2.69 BS02 SFG A 1 W10 A11 G12 P34 F35 V36 A38 S40 D54 I55 S164 Y165 D181 F201 W8 A9 G10 P32 F33 V34 A36 S38 D52 I53 S162 Y163 D179 F188 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRSKKVDELLALYKP 4rtq A 2.00 BS02 SAH A 1 W10 A11 G12 P34 F35 G37 D54 I55 S164 Y165 D181 P182 P183 Y184 W8 A9 G10 P32 F33 G35 D52 I53 S162 Y163 D179 P180 P181 Y182 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSASFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVDELLALYKPGV 4rts A 2.49 BS02 SAM A 1 W10 A11 G12 P34 F35 D54 I55 E163 S164 Y165 D181 P182 P183 Y184 W8 A9 G10 P32 F33 D52 I53 E161 S162 Y163 D179 P180 P181 Y182 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVDELLALYKP 4rwk A 2.98 BS01 66T A 1 L484 G490 V492 A512 K514 I545 E562 A564 S565 K566 G567 E571 N628 L630 D641 L28 G34 V36 A56 K58 I89 E106 A108 S109 K110 G111 E115 N172 L174 D185 2.7.10.1 P11362 25686244 MAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIMEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 4rwk B 2.98 BS01 66T B 1 L484 G485 A512 K514 E531 M535 M561 E562 A564 S565 G567 L630 A640 D641 F642 L26 G27 A54 K56 E73 M77 M103 E104 A106 S107 G109 L156 A166 D167 F168 2.7.10.1 P11362 25686244 GVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIMEYASKGNLREYLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAIDYYKKTGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSN 4rwl B 2.19 BS01 3ZC B 1 L484 V492 A512 K514 E531 M535 V559 V561 E562 Y563 A564 S565 L630 A640 D641 F642 L644 L27 V35 A52 K54 E71 M75 V99 V101 E102 Y103 A104 S105 L157 A167 D168 F169 L171 2.7.10.1 P11362 25686244 AGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 4rxa A 2.20 BS01 3F2 A 1 K14 K57 N59 R60 L62 T63 V66 F239 D243 V340 G343 K347 K3 K46 N48 R49 L51 T52 V55 F226 D230 V320 G323 K327 2.5.1.10,2.5.1.1 P14324 25815158 QEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQIKENYGQVAVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4rxc A 2.31 BS01 HRX A 1 Y99 D103 D107 R112 Q172 K212 Y216 Y88 D92 D96 R101 Q161 K199 Y203 Q86C09 25815158 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPRLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc A 2.31 BS04 HRX A 2 F251 Q252 D255 K269 F238 Q239 D242 K255 Q86C09 25815158 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPRLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxc B 2.31 BS01 HRX B 1 Y99 L100 D103 D107 R112 T168 Q172 K212 Y216 Y89 L90 D93 D97 R102 T158 Q162 K199 Y203 Q86C09 25815158 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKR 4rxd A 2.00 BS03 RIS A 1 L100 D103 D107 R112 Q172 K212 T213 D255 K269 L88 D91 D95 R100 Q160 K200 T201 D243 K257 Q86C09 25815158 MQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4rxe B 2.50 BS01 3YQ B 1 L100 D103 D107 R112 K212 T213 Y216 D255 L92 D95 D99 R104 K204 T205 Y208 D247 Q86C09 25815158 MPMQMFMQVYDEIQMFLLEELELKFDMDPNRVRYLRKMMDTTCLGGKYNRGLTVIDVAESLLSLDDGARRKRVLHDACVCGWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFFADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRIVKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLGKVGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYVAYEAAVAEQVKELIEKLRLCSPGFAASVETLWGKTYKRQK 4tt8 A 2.30 BS01 6DD A 1 R60 C86 S87 Q88 F89 I90 M92 I95 I104 H106 G115 A116 D138 G140 L141 D142 I203 R60 C86 S87 Q88 F89 I90 M92 I95 I104 H106 G115 A116 D138 G140 L141 D142 I203 1.5.1.6 E3NZ06 MKIAVIGQSLFGQEVYKELKNEGHMIVGVFTIPDKDGKVDPLAIEAEKDGVPVFKFPRWRLKGKAITEVVDQYKAVGAELNVLPFCSQFIPMEVIDHPKHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTVFWADDGLDTGPILLQRECDVEPNDNVNSIYKRFLFPEGVKGMVEAVRLIATGKAPRIKQPEEGATYECIQKKENSKIDWNQPAEAIHNWIRGNDRVPGAWAEIDGKSVSFYGSTLLENDHFSSNGQPLEIPGASRAALVTKNGLVLFGNDGKMLLVKNLQFEDGKMIPGSQYFK 4tts A 2.00 BS01 6DD A 1 R58 C86 S87 Q88 F89 I90 I104 G115 A116 D138 G140 L141 D142 R58 C86 S87 Q88 F89 I90 I104 G115 A116 D138 G140 L141 D142 1.5.1.6 E3NZ06 MKIAVIGQSLFGQEVYKELKNEGHMIVGVFTIPDKDGKVDPLAIEAEKDGVPVFKFPRWRLKGKAITEVVDQYKAVGAELNVLPFCSQFIPMEVIDHPKHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTVFWADDGLDTGPILLQRECDVEPNDNVNSIYKRFLFPEGVKGMVEAVRLIATGKAPRIKQPEEGATAECIQKKENSKIDWNQPAEAIHNWIRGNDRVPGAWAEIDGKSVSFYGSTLLENDHFSSNGQPLEIPGASRAALVTKNGLVLFGNDGKMLLVKNLQFEDGKMIPGSQYFK 4u6z A 1.80 BS03 Q07 A 1 F198 C203 H212 D229 T231 D240 H303 M309 H310 E336 W353 E367 F109 C114 H123 D140 T142 D151 H214 M220 H221 E247 W264 E278 3.4.11.18 P53582 25699713 YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS 4uyp B 1.49 BS01 CA B 1 D42 D44 N46 S48 D53 D42 D44 N46 S48 D53 Q7WYN3 KFIYGDVDGNGSVRSIDAVLIRDYVLGKINEFPYEYGMLAADVDGNGSIKINDAVLVRDYVLGKIFLFPVEEK 4uyq A 1.81 BS01 CA A 1 D5 I6 N135 D136 G137 D5 I6 N135 D136 G137 Q7WYN2 MLQVDIGSTSGKAGSVVSVPITFTNVPKSGIYALSFRTNFDPQKVTVASIDAGSLIENASDFTTYYNNENGFASMTFEAPVDRARIIDSDGVFATINFKVSDSAKVGELYNITTNSAYTSFYYSGTDEIKNVVYNDGKIEVIA 4uyq B 1.81 BS02 CA B 2 D42 D44 S48 D53 D42 D44 S48 D53 Q7WYN3 KFIYGDVDGNGSVRINDAVLIRDYVLGKINEFPYEYGMLAADVDGNGSIKSIDAVLVRDYVLGKIFLFPVEEK 4wc0 A 3.10 BS01 ATP A 1 G17 G18 R21 R104 D105 N109 D149 R152 R155 R162 R191 G17 G18 R21 R92 D93 N97 D137 R140 R143 R150 R179 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARREPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKELGERIEELKREIMNK 4wc2 A 2.80 BS01 NUC B 1 T82 R103 D149 R152 G190 R191 N194 K197 R201 S281 S284 R287 K349 G365 K366 G369 T82 R93 D139 R142 G180 R181 N184 K187 R191 S271 S274 R277 K339 G351 K352 G355 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wc2 A 2.80 BS02 APC A 1 G17 R21 R104 D105 N109 D149 R152 R155 F159 R162 G17 R21 R94 D95 N99 D139 R142 R145 F149 R152 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wc3 A 3.10 BS01 NUC B 1 D33 F61 E74 T82 R103 R104 D105 N109 D149 R152 R155 G190 R191 N194 K197 R201 S281 S284 K318 H321 G365 K366 L368 G369 D33 F61 E74 T82 R93 R94 D95 N99 D139 R142 R145 G180 R181 N184 K187 R191 S271 S274 K308 H311 G351 K352 L354 G355 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wc4 A 3.50 BS01 NUC B 1 G190 K197 R201 S281 S284 K318 K349 G365 K366 G369 G180 K187 R191 S271 S274 K308 K339 G351 K352 G355 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wc5 A 3.41 BS02 CTP A 1 G18 R21 R103 R104 D105 N109 D149 R152 R155 R162 G18 R21 R93 R94 D95 N99 D139 R142 R145 R152 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wc6 A 3.41 BS01 NUC B 1 F61 T82 G190 R191 K197 R201 S281 S284 K318 K349 G365 K366 L368 G369 I372 F61 T82 G180 R181 K187 R191 S271 S274 K308 K339 G351 K352 L354 G355 I358 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wc6 A 3.41 BS02 ATP A 1 G17 G18 R104 D105 N109 D149 R152 R155 R158 F159 R162 R191 G17 G18 R94 D95 N99 D139 R142 R145 R148 F149 R152 R181 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4wdt A 1.50 BS02 WDT A 1 Y24 L54 Y55 W86 H117 Y216 W227 F306 F311 Y19 L49 Y50 W81 H112 Y211 W222 F301 F306 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 4wdu A 1.70 BS02 WDU A 1 Y24 L54 Y55 H117 S118 M120 N167 Y216 W227 F306 P318 Y319 Y19 L49 Y50 H112 S113 M115 N162 Y211 W222 F301 P313 Y314 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 4wdw A 1.94 BS02 WDW A 1 Y24 L54 Y55 W86 H117 S118 M120 N167 F306 Y19 L49 Y50 W81 H112 S113 M115 N160 F298 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGLSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYF 4wdw B 1.94 BS02 WDW B 1 Y24 L54 Y55 W86 H117 M120 W227 F306 S308 Y19 L49 Y50 W81 H112 M115 W220 F299 S301 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGLSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNS 4wdx A 1.64 BS01 NAP A 1 G22 T23 Y24 D50 Y55 H117 S166 N167 Q190 Y216 S217 A218 L219 S221 Q222 L236 A253 L268 A269 K270 S271 Y272 N273 R276 Q279 N280 G17 T18 Y19 D45 Y50 H112 S153 N154 Q177 Y203 S204 A205 L206 S208 Q209 L223 A240 L255 A256 K257 S258 Y259 N260 R263 Q266 N267 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGLSPTIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSF 4wdx A 1.64 BS02 WDX A 1 Y24 L54 Y55 W86 H117 S118 M120 N167 Q222 W227 F306 S308 F311 Y19 L49 Y50 W81 H112 S113 M115 N154 Q209 W214 F293 S295 F298 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGLSPTIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSF 4wod A 1.90 BS01 ARG A 1 L60 L61 R63 E222 C268 S270 N271 L60 L61 R63 E222 C268 S270 N271 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTHGEHTESVGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe A 2.30 BS01 ADP A 1 S119 R121 R123 H182 M230 R277 S279 V280 H281 R305 E310 D320 S119 R121 R123 H182 M230 R277 S279 V280 H281 R305 E310 D320 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTHGEHTESVGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGLYGEHTESPDGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe A 2.30 BS02 ADP A 2 S482 R484 R486 H545 W581 R589 R640 S642 V643 L644 R669 L671 Y672 G673 E674 D684 S482 R484 R486 H545 W581 R589 R640 S642 V643 L644 R669 L671 Y672 G673 E674 D684 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTHGEHTESVGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGLYGEHTESPDGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe A 2.30 BS03 3S5 A 1 A59 L60 L61 R63 E222 C268 S270 A59 L60 L61 R63 E222 C268 S270 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTHGEHTESVGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGLYGEHTESPDGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe A 2.30 BS04 3S5 A 2 S422 I423 C424 R426 E585 C631 E674 H675 S422 I423 C424 R426 E585 C631 E674 H675 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTHGEHTESVGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGLYGEHTESPDGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe B 2.30 BS01 ADP B 1 S119 R121 R123 R277 S279 V280 H281 R305 D320 S119 R121 R123 R277 S279 V280 H281 R305 D312 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe B 2.30 BS02 ADP B 2 S482 R484 R486 R589 R640 S642 V643 L644 R669 D684 S474 R476 R478 R581 R632 S634 V635 L636 R661 D666 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe B 2.30 BS03 3S5 B 1 A59 L60 L61 R63 C268 S270 A59 L60 L61 R63 C268 S270 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4woe B 2.30 BS04 3S5 B 2 S422 I423 C424 R426 E585 C631 S633 S414 I415 C416 R418 E577 C623 S625 2.7.3.4 P16641 25837252 MQVESLQNLQVKIRNDERNHSLTKKYLTDDIVKKYQATKTSLGGTLAQCVNTNAYNPGALLPRSCDLNAYETFRDFFDAVIADYHKVPDGKIQHPKSNFGDLKSLSFTDLNTYGNLVVSTRVRLGRTVEGFGFGPTLTKETRIELENKISTALHNLSGEYEGTYYPLTGMSEEDRIKLVNDHFLFRNDDNVLRDAGGYIDWPTGRGIFINKQKNFLVWINEEDHIRVISMQKGGGLTAVYKRLADAIQELSKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQPRGTGGIYDLSNKRRLGLTELDAVTEMHSGVRALLELEVMLQEYNKGAPEGVMPVEPLTYLAKLLEGASIEKCYTRKYLTPEIIKKYDGKRTTHGATLAHMIRNGAYNNRSICPRTGEAECYSTFIDYLDPLICDYHGVKDSAFKHPAPTFGDLSKLPFGDLDPTGKFIVSTRVRVGRSVEGFLFPTIMSKTDRIKLEQVISGALKGLTGEHAGTYYPLTDMKEEDRKQLVEDHFLFKNDDPVLRDAGGYRDWPVGRGIFHNNSKTFLVWVCEEDHMRIISMQQGGNLAAVYKRLIEGINAIGKSMKFAHSDKYGYITCCPSNLGTSMRASVLLKIPKLSSQPKKLDEICAKYMLQARGGTYDISNKRRLGLTELQAAHEMAEGVAKMIEIEKGL 4x0a A 3.51 BS01 NUC B 1 K72 E74 R191 N194 K197 R201 S281 P283 K318 H321 K366 K72 E74 R181 N184 K187 R191 S271 P273 K308 H311 K352 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4x0b A 3.20 BS01 NUC B 1 G18 F58 F61 R103 R104 D105 N109 D149 R152 R155 G190 R191 K197 S281 S284 K318 H321 K366 L368 G369 G18 F58 F61 R93 R94 D95 N99 D139 R142 R145 G180 R181 K187 S271 S274 K308 H311 K352 L354 G355 O66728 MVGQIAKEMGLRAYIVGGVVRDILLGKEVWDVDFVVEGNAIELAKELARRHGVNVHPFPEFGTAHLKIGKLKLEFATARRETEPASLKEDLIRRDFTINAMAISVNLEDYGTLIDYFGGLRDLKDKVIRVLHPVSFIEDPVRILRALRFAGRLNFKLSRSTEKLLKQAVNLGLLKEAPRGRLINEIKLALREDRFLEILELYRKYRVLEEIIEGFQWNEKVLQKLYALRKVVDWHALEFSEERIDYGWLYLLILISNLDYERGKHFLEEMSAPSWVRETYKFMKFKLGSLKEELKKAKENYEVYRLLKPLHTSVLLLLMLEEELKEKIKLYLEKLRKVKLPKEKIEELKKGKELGERIEELKREIMN 4x5y A 1.59 BS01 3XW A 1 S155 L177 S178 D180 H181 A182 F238 Y276 M278 M322 Y323 W341 E363 E366 V371 S134 L156 S157 D159 H160 A161 F217 Y255 M257 M301 Y302 W320 E342 E345 V350 O00255 25817203 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKK 4x5z A 1.86 BS01 3XY A 1 S155 L177 S178 D180 H181 A182 F238 Y276 M278 M322 Y323 W341 E363 S134 L156 S157 D159 H160 A161 F217 Y255 M257 M301 Y302 W320 E342 O00255 25817203 GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMK 4xhc A 2.70 BS01 RAM A 1 D217 W226 D229 Y284 W341 E486 Y498 H508 W510 D207 W216 D219 Y274 W331 E476 Y488 H498 W500 3.2.1.40 G8WCL1 VMMTRHPNFLRTAEALRPALSRQAHPPIAVVEAHADAAALFGWRAEPVSTLAAFYQRELSSGDSVIIDFGSHYVGYLHFLCQSAGSPPDAPAHLQLTFGETLSEVCEPFSDYQGWLSSSWLQQQDLWLDVLPAEIDLPRRYCFRYLKVEVKAVSRKFRLQFTQIEVNAVTSASGACPAATTSDPQLRAIDNVAVLTLQNCMQEVFEDGPKRDRRLWLGDLRLQALVNDVTFARHDLVRRCLYLFAGHTREDGMVSANVFVQPDVIADDTFLFDYSLFFVDVLYNYLQSAEDMATARELWPTARRQVELALTRCDASGVVRDSDDWWVFIDWQASLNKQAAAQGVLIYCLQRAIWLAERFEPELAVSYRQRLQQLKSAALDALWDPQQGFYVSGARRQVSWASQIWLVLAEVGTPQQRREIMRNLEKNPPAVAMNTPYLRHHYIAALLQCGLRDEAIAQIKAYWGAMVDYGADTFWEIFDPAHPDFSPYGSKLINSYCHAWSCTPAWFIRQYGL 4xhc B 2.70 BS01 RAM B 1 D217 D222 W226 D229 Y284 F338 W341 E486 Y498 H508 W510 D207 D212 W216 D219 Y274 F328 W331 E476 Y488 H498 W500 3.2.1.40 G8WCL1 VMMTRHPNFLRTAEALRPALSRQAHPPIAVVEAHADAAALFGWRAEPVSTLAAFYQRELSSGDSVIIDFGSHYVGYLHFLCQSAGSPPDAPAHLQLTFGETLSEVCEPFSDYQGWLSSSWLQQQDLWLDVLPAEIDLPRRYCFRYLKVEVKAVSRKFRLQFTQIEVNAVTSASGACPAATTSDPQLRAIDNVAVLTLQNCMQEVFEDGPKRDRRLWLGDLRLQALVNDVTFARHDLVRRCLYLFAGHTREDGMVSANVFVQPDVIADDTFLFDYSLFFVDVLYNYLQSAEDMATARELWPTARRQVELALTRCDASGVVRDSDDWWVFIDWQASLNKQAAAQGVLIYCLQRAIWLAERFEPELAVSYRQRLQQLKSAALDALWDPQQGFYVSGARRQVSWASQIWLVLAEVGTPQQRREIMRNLEKNPPAVAMNTPYLRHHYIAALLQCGLRDEAIAQIKAYWGAMVDYGADTFWEIFDPAHPDFSPYGSKLINSYCHAWSCTPAWFIRQYGL 4xjk B 1.76 BS02 CA B 1 D67 N69 D71 Q73 E78 D64 N66 D68 Q70 E75 P06702 25597447 KMSQLERNIETIINTFHQYSVKLGHPDTLNQGEFKELVRKDLQNFLKKENKNEKVIEHIMEDLDTNADKQLSFEEFIMLMARLTWASHEKMHEGDEGPGHHHKPGLGE 4xuc A 1.80 BS01 43G A 1 W88 D191 K194 D219 N220 C223 P224 L248 E249 R251 W41 D144 K147 D172 N173 C176 P177 L201 E202 R204 2.1.1.6 P21964 25815153 NLLAGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xuc A 1.80 BS02 MG A 1 D191 K194 D219 N220 D144 K147 D172 N173 2.1.1.6 P21964 25815153 NLLAGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xuc A 1.80 BS03 SAM A 1 M90 N91 V92 G116 A117 Y118 Y121 S122 E140 I141 G167 A168 S169 D191 H192 W193 M43 N44 V45 G69 A70 Y71 Y74 S75 E93 I94 G120 A121 S122 D144 H145 W146 2.1.1.6 P21964 25815153 NLLAGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xud A 2.40 BS01 43H A 1 W88 M90 D191 H192 W193 K194 D219 N220 P224 L248 E249 W41 M43 D144 H145 W146 K147 D172 N173 P177 L201 E202 2.1.1.6 P21964 25815153 NLLAGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xue B 2.30 BS01 43J B 1 M90 D191 H192 W193 K194 D195 D219 N220 E249 M40 D141 H142 W143 K144 D145 D169 N170 E199 2.1.1.6 P21964 25815153 AGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xue B 2.30 BS03 SAM B 1 M90 N91 V92 G116 A117 Y118 Y121 S122 I139 E140 I141 G167 A168 S169 Q170 D191 H192 W193 M40 N41 V42 G66 A67 Y68 Y71 S72 I89 E90 I91 G117 A118 S119 Q120 D141 H142 W143 2.1.1.6 P21964 25815153 AGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xue A 2.30 BS01 43J A 1 M90 D191 H192 W193 K194 D195 D219 N220 P224 E249 M39 D140 H141 W142 K143 D144 D168 N169 P173 E198 2.1.1.6 P21964 25815153 GDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 4xuf A 3.20 BS01 P30 A 1 L616 V624 A642 E661 M664 M665 I674 V675 C694 C695 Y696 G697 H809 L818 I827 C828 D829 F830 L17 V25 A43 E59 M62 M63 I72 V73 C92 C93 Y94 G95 H132 L141 I150 C151 D152 F153 2.7.10.1 P36888 25837374 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKESSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL 4xuf B 3.20 BS01 P30 B 1 L616 V624 A642 K644 E661 M664 M665 I674 Y693 C694 C695 G697 H809 L818 C828 D829 F830 L17 V25 A43 K45 E62 M65 M66 I75 Y94 C95 C96 G98 H137 L146 C156 D157 F158 2.7.10.1 P36888 25837374 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQ 4xvd A 2.81 BS01 NAP A 1 G22 T23 Y24 D50 Y55 K84 H117 S166 N167 Q190 Y216 S217 L219 G220 S221 Q222 L236 A253 L268 K270 S271 Y272 R276 Q279 N280 G17 T18 Y19 D45 Y50 K79 H112 S159 N160 Q183 Y209 S210 L212 G213 S214 Q215 L229 A246 L261 K263 S264 Y265 R269 Q272 N273 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSD 4xvd A 2.81 BS02 WDV A 1 Y24 L54 Y55 H117 N167 D224 W227 F306 N307 S308 F311 Y317 Y319 Y19 L49 Y50 H112 N160 D217 W220 F299 N300 S301 F304 Y310 Y312 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSD 4xvd B 2.81 BS01 NAP B 1 G22 T23 Y24 D50 Y55 K84 H117 S166 N167 Q190 Y216 S217 L219 S221 Q222 L236 A253 L268 A269 K270 S271 R276 Q279 N280 G17 T18 Y19 D45 Y50 K78 H111 S159 N160 Q183 Y209 S210 L212 S214 Q215 L229 A246 L261 A262 K263 S264 R267 Q270 N271 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDNGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSSFASHPNYPYSD 4xvd B 2.81 BS02 WDV B 1 Y24 L54 Y55 H117 N167 W227 F306 N307 Y317 Y319 Y19 L49 Y50 H111 N160 W220 F297 N298 Y307 Y309 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDNGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSSFASHPNYPYSD 4xve A 1.55 BS02 WDS A 1 Y24 L54 W86 S118 M120 L122 S129 V137 N167 R226 W227 F306 S310 F311 Y317 P318 Y319 Y19 L49 W81 S113 M115 L117 S124 V132 N162 R221 W222 F301 S305 F306 Y312 P313 Y314 1.1.1.64 P42330 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYS 4xxl A 1.47 BS01 HEM A 1 N42 C43 C46 H47 D54 G55 P56 Y58 V61 K64 Y65 H78 V79 A85 K86 H95 K96 I98 N15 C16 C19 H20 D27 G28 P29 Y31 V34 K37 Y38 H51 V52 A58 K59 H68 K69 I71 D5CN26 AVDVDAAKSLARENNCFKCHGVDKEKDGPSYKKVAEKYRGKADAEAKLIHHVTSGEKAKFPDGHEEEHKNINGKASPEAIKNLVDWILSLWS 4xzf A 1.38 BS01 NUC B 1 V68 G69 Y72 Y73 N91 Y93 D94 H110 L111 K112 K113 V16 G17 Y20 Y21 N39 Y41 D42 H58 L59 K60 K61 3.6.4.-,6.3.2.- Q14527 GPLGSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGP 4y7r A 1.90 BS01 III B 1 R181 P224 N225 Y228 K250 F266 V268 Q289 R151 P194 N195 Y198 K220 F236 V238 Q259 P61964 25818646 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 4y8w A 2.64 BS01 HEM A 1 R92 S109 W117 K121 I173 D288 G292 G293 T296 T297 L354 V359 V360 A363 H366 L389 A421 F422 R427 C429 L430 G431 A435 R64 S81 W89 K93 I145 D251 G255 G256 T259 T260 L311 V316 V317 A320 H323 L346 A376 F377 R382 C384 L385 G386 A390 Q16874 KLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRG 4y8w A 2.64 BS02 STR A 1 V101 S109 V198 L199 W202 R234 D288 I291 G292 V360 L364 V470 V73 S81 V170 L171 W174 R206 D251 I254 G255 V317 L321 V425 Q16874 KLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRG 4y8w B 2.64 BS01 HEM B 1 R92 S109 W117 K121 I173 G292 G293 T296 T300 L354 V360 A363 L364 H366 L389 A421 F422 R427 C429 L430 G431 R64 S81 W89 K93 I145 G256 G257 T260 T264 L310 V316 A319 L320 H322 L345 A377 F378 R383 C385 L386 G387 Q16874 KLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 4y8w C 2.64 BS01 HEM C 1 R92 S109 W117 K121 I173 L289 G292 G293 T296 T300 V359 V360 L364 H366 L389 A421 F422 R427 C429 L430 G431 A435 R64 S81 W89 K93 I145 L253 G256 G257 T260 T264 V316 V317 L321 H323 L346 A378 F379 R384 C386 L387 G388 A392 Q16874 KLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHESRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRG 4y8w C 2.64 BS02 STR C 1 V101 S109 L110 V198 L199 W202 I231 R234 D288 I291 G292 V360 L364 V73 S81 L82 V170 L171 W174 I203 R206 D252 I255 G256 V317 L321 Q16874 KLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHESRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRG 4y97 B 2.51 BS01 ZN B 1 C1283 C1286 C1310 C1315 C16 C19 C43 C48 2.7.7.7 P09884 TDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF 4yd0 A 2.62 BS01 4EW A 1 F23 S24 F25 R55 H57 E61 F63 K76 F104 Q106 M131 F3 S4 F5 R35 H37 E41 F43 K56 F84 Q86 M111 Q30NP1 25827523 SSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGKDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIVMGMVGVLPDMTPSTEMSMRGIRVSKM 4yle A 1.70 BS01 UNL A 1 K40 N44 F46 D124 N178 R182 W205 N231 D257 Q277 K11 N15 F17 D95 N149 R153 W176 N202 D228 Q248 A9AIX1 AGKPKVALVMKSLANEFFLTMENGAKEYQKHNASQFDLITNGIKDETDTANQIRIVEQMIVSKVDAIVLAPADSKALVPVVKKAVDAGIIVVNIDNRLDPDVLKSKNLNVPFVGPDNRKGARKVGDYLAKKLKAGDQVGIVEGVSTTTNAQQRTAGFQDAMKAGGMKVVSVQSGEWEIDKGNAVASAMLNEYPNLKALLCGNDNMAIGAVSAVRAAGKQGKVYVVGYDNINAIKPMLKDGRVLATADQYAAKQAVFGIDTALKAIAEHRKQAELVETPVDLVT 4yn0 A 2.20 BS01 MG A 1 C150 P151 W154 S177 V179 C102 P103 W106 S129 V131 Q9EPU5 25838500 SLPGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNMSLRVCSSCPAGTFTRHENGIERCHDCSQPCPWPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKGTENEDVRCKQCARGTFSDVPSSVMKCKAHTDCLGQNLEVVKPGTKETDNVCGMRLF 4ywh A 2.35 BS01 XYP A 1 L37 R39 D113 R114 D158 N160 W192 N219 D245 K265 L15 R17 D91 R92 D136 N138 W170 N197 D223 K243 3.6.3.17 A6VLM7 MKDLTIGMSIDDLRLERWQKDRDIFVKKAESLGAKVLVQSANGDDSAQISQIENMLNKNVDVLVIIPHNGDVLSNVISEAKKEGVKVLAYDRLINNADLDFYVSFDNEKVGELQADAIIKEKPEGNYFLMGGSPVDNNAKLFRKGQMKVLQPLIDSGKIKVVGDQWVDSWLAEKALQIMENALTANKNNIDAVVASNDATAGGAIQALSAQGLSGKVAISGQDADLAAIKRIVEGTQTMTVYKPITNLADKAAELSVALGKEEKLEPNAKLNNGLKEVDAYLLDPIVVTKDNIDSTVIKDGFHSKEAVYK 4yz8 A 1.80 BS01 SAM A 1 R1155 W1157 T1197 N1198 F1199 Y1200 R1220 F1221 N1223 H1224 Y1261 E1272 C1273 H1274 L1284 R87 W89 T129 N130 F131 Y132 R152 F153 N155 H156 Y193 E199 C200 H201 L211 2.1.1.43 Q9BZ95 KPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLGRTECHCGADNCSGFL 4yz8 A 1.80 BS02 ZN A 1 C1098 C1100 C1108 C1114 C30 C32 C40 C46 2.1.1.43 Q9BZ95 KPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLGRTECHCGADNCSGFL 4z0n A 1.26 BS01 GAL A 1 Y34 D38 F40 L41 N116 K117 Q177 D179 R183 W208 N236 D260 Q280 Y9 D13 F15 L16 N91 K92 Q152 D154 R158 W183 N211 D235 Q255 D1AWX5 KITLGVTYYKFDDNFLAGMRNDMIQIAKEKYPNIELLNNDSQNSQSILNDQIEVLINKGVNVLVINLVDPTAGQSVIDKAKAANIPIILFNKDPGVDALNSYDKAWYVGTTPKDSGILQGQVIEKAWLANPAYDLNGDGVIQYVMLFGEPGQPDAEARTKYSIEYLNEKGIKTEELHKDIANWDAAQAKDKMDAWLSGPNANKIEVVIANNDGMALGAVESIKAVKKELPVFGVDAIQEALTLIEKGEMVGTVLQDATGQARAILELANNIANGKEPTEGTEWKLIDKAVRVPYVGVDKDNYKEFQK 4z0n A 1.26 BS02 CA A 1 D159 N161 D163 V165 Q167 E230 D134 N136 D138 V140 Q142 E205 D1AWX5 KITLGVTYYKFDDNFLAGMRNDMIQIAKEKYPNIELLNNDSQNSQSILNDQIEVLINKGVNVLVINLVDPTAGQSVIDKAKAANIPIILFNKDPGVDALNSYDKAWYVGTTPKDSGILQGQVIEKAWLANPAYDLNGDGVIQYVMLFGEPGQPDAEARTKYSIEYLNEKGIKTEELHKDIANWDAAQAKDKMDAWLSGPNANKIEVVIANNDGMALGAVESIKAVKKELPVFGVDAIQEALTLIEKGEMVGTVLQDATGQARAILELANNIANGKEPTEGTEWKLIDKAVRVPYVGVDKDNYKEFQK 4z24 A 2.00 BS01 FAD A 1 G13 G15 A16 A17 E37 A38 S68 W75 A93 H94 G95 M96 G97 G100 S101 T102 I104 N105 R106 L107 N108 A261 V263 T297 S298 G299 S577 H578 D605 L606 N616 T617 W618 A621 G10 G12 A13 A14 E34 A35 S65 W72 A90 H91 G92 M93 G94 G97 S98 T99 I101 N102 R103 L104 N105 A258 V260 T294 S295 G296 S574 H575 D602 L603 N613 T614 W615 A618 1.-.-.- Q5UPL2 NLTGDIVIIGAGAAGSLLAHYLARFSNMKIILLEAGHSHFNDPVVTDPMGFFGKYNPPNENISMSQNPSYSWQGAQEPNTGAYGNRPIIAHGMGFGGSTMINRLNLVVGGRTVFDNDWPVGWKYDDVKNYFRRVLVDINPVRDNTKASITSVALDALRIIAEQQIASGEPVDFLLNKATGNVPNVEKTTPDAVPLNLNDYEGVNSVVAFSSFYMGVNQLSDGNYIRKYAGNTYLNRNYVDENGRGIGKFSGLRVVSDAVVDRIIFKGNRAVGVNYIDREGIMHYVKVNKEVVVTSGAFYTPTILQRSGIGDFTYLSSIGVKNLVYNNPLVGTGLKNHYSPVTITRVHGEPSEVSRFLSNMAANPTNMGFKGLAELGFHRLDPNKPANANTVTYRKYQLMMTAGVGIPAEQQYLSGLSPSSNNLFTLIADDIRFAPEGYIKIGTPNIPRDVPKIFFNTFVTYTPTSAPADQQWPIAQKTLAPLISALLGYDIIYQTLMSMNQTARDSGFQVSLEMVYPLNDLIYKLHNGLATYGANWWHYFVPTLVGDDTPAGREFADTLSKLSYYPRVGAHLDSHQGCSCSIGRTVDSNLKVIGTQNVRVADLSAAAFPPGGNTWATASMIGARAVDLILGFPYLRDLPVNDVPILNVN 5aff A 3.40 BS01 III B 1 S207 T211 E214 G316 T317 Q320 S447 N451 W454 T455 C458 W507 D550 F552 Q553 K558 G610 E651 R655 E658 N662 R665 F666 Y669 S182 T186 E189 G280 T281 Q284 S354 N358 W361 T362 C365 W414 D444 F446 Q447 K452 G504 E545 R549 E552 N556 R559 F560 Y563 G0S5S6 25849277 PELAKLREDKILPVLKDLKSPDAKSRTTAAGAIANIVQDAKCRKLLLREQVVHIVLTETLTDNNIDSRAAGWEILKVLAQEEEADFCVHLYRLDVLTAIEHAAKAVLETLTTSEPPFSKLLKAQQRLVWDITGSLLVLIGLLALARDEIHEAVATKQTILRLLFRLISADIAPQDIYEEAISCLTTLSEDNLKVGQAITDDQETHVYDVLLKLATGTDPRAVMACGVLHNVFTSLQWMDHSPGKDGACDAILIPTLTRALEHVVYANITLLALVTLASIGTDFQETLVKGNSITSEMQADMERVVGADGTDDGDLEDLPTLRELIQTAVPQLIRLSNLPIDSDESLTIQSHALSALNNISWTISCLEFANGENANIHNAWYPTAKKIWRKTILPILEADSADLKLATQVTSLAWAVARVLHGETPTDGNPHRKFISLYHSSKEDPFQGLGVKCIGVVGSLAHDPAPIEVNREVGVFLVTLLRQSNNVPPAEIVEALNQLFDIYGDEELACDKEVFWKDGFLKHLEEFLPKMRTLTKGIDKRTQPELRTRADEALLNLGRFVQYKKKHA