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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
TFKRRNGGRNKHGRGHVKYIRCSNCAKCCPKDKAIKRFLVRNIVEQAAVRDVQEACVHDGYVLPKLYAKVHHCVSCAIHA
HIVRVRSRENRRNREPPQ

The query sequence (length=98) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8jiw:Ba 98 98 1.0000 1.0000 1.0000 4.49e-68 8ip8:db, 8ip9:db, 8ipa:db, 8ipb:db, 8r6f:a, 4v7e:Ba
2 8auv:J 98 98 0.8061 0.8061 0.8061 1.47e-55 8b2l:J1, 7qix:N, 7qiz:DA
3 4v6w:Aa 107 97 0.7245 0.6636 0.7320 8.41e-49 6xu6:Aa, 6xu7:Aa, 6xu8:Aa
4 6ip5:3C 107 97 0.6939 0.6355 0.7010 3.21e-46 7a01:O3, 7a09:Q, 5a2q:a, 5aj0:Ba, 9bdl:AS26, 9bdn:AS26, 9bdp:AS26, 8bhf:b3, 9bkd:Q, 9bln:Q, 8btk:AE, 7cpu:Sa, 7cpv:Sa, 4d5l:a, 4d61:a, 6d90:bb, 6d9j:bb, 9f1b:AE, 9f1c:AE, 9f1d:AE, 6fec:k, 5flx:a, 6g5h:a, 8g5y:Sa, 8g5z:Sa, 8g60:Sa, 8g61:Sa, 8g6j:Sa, 8glp:Sa, 6gz3:Ba, 6gz4:Ba, 6gz5:Ba, 6hcf:b1, 6hcj:b2, 6hcm:b1, 6hcq:b2, 8ifd:3C, 8ife:3C, 6ip6:3C, 6ip8:3C, 3j7p:Sa, 3j7r:Sa, 3jag:aa, 3jah:aa, 3jai:aa, 3jaj:Sa, 3jan:Sa, 8jdj:AM, 8jdk:AM, 8jdl:AM, 8jdm:AM, 7jqb:b, 7jqc:b, 5k0y:k, 8k2c:Sa, 7k5i:a, 4kzx:a, 4kzy:a, 4kzz:a, 5lks:Sa, 7ls1:F3, 7ls2:F3, 5lzs:aa, 5lzt:aa, 5lzu:aa, 5lzv:aa, 5lzw:aa, 5lzx:aa, 5lzy:aa, 5lzz:aa, 7mdz:aa, 6mtb:aa, 6mtc:aa, 6mtd:aa, 6mte:aa, 7nwg:b2, 7nwh:aa, 7nwi:aa, 7o7y:AE, 7o7z:AE, 7o80:AE, 7o81:AE, 5oa3:a, 6ole:Sa, 6olf:Sa, 6olg:Ba, 6oli:Sa, 6olz:Ba, 6om0:Sa, 6om7:Sa, 7oya:a2, 7oyb:a2, 7oyc:a2, 7oyd:Aa, 8oz0:R, 8p03:b, 8p09:b, 8p2k:AE, 6p4g:b, 6p4h:b, 6p5i:b, 6p5j:b, 6p5k:b, 6p5n:b, 8pj1:Q, 8pj2:Q, 8pj3:Q, 8pj4:Q, 8pj5:Q, 8pj6:Q, 8ppk:a, 8ppl:Aa, 8q7z:AE, 8q87:AE, 7qgg:Sa, 8qoi:Sa, 7qp6:Q, 7qp7:Q, 7qvp:Sa, 7qvp:Ra, 6qzp:Sa, 7r4x:a, 6r5q:LL, 6r6g:LL, 6r6p:ZZ, 6r7q:LL, 8rg0:Q, 8scb:aa, 6sgc:b1, 7syg:b, 7syh:b, 7syi:b, 7syj:b, 7syk:b, 7syl:b, 7sym:b, 7syn:b, 7syo:b, 7syp:b, 7syq:b, 7syr:b, 7sys:b, 7syt:b, 7syu:b, 7syv:b, 7syw:b, 7syx:b, 5t2c:AE, 8t4s:a, 7toq:AS26, 7tor:AS26, 7tql:c, 7ucj:Aa, 7uck:Aa, 4ug0:Sa, 4ujc:Ca, 4ujd:Ca, 4uje:Ba, 4v6x:Aa, 5vyc:a1, 5vyc:a2, 5vyc:a3, 5vyc:a4, 5vyc:a5, 5vyc:a6, 6w2s:b, 6w2t:b, 6xa1:Sa, 7xnx:Sa, 7xny:Sa, 8xsx:Sa, 8xsy:Sa, 8xsz:Sa, 8xxl:Sa, 8xxm:Sa, 8xxn:Sa, 6y0g:Sa, 8y0w:Sa, 8y0x:Sa, 6y2l:Sa, 6y57:Sa, 6yal:b, 6yam:b, 6yan:b, 6ybw:Q, 8yoo:Sa, 8yop:Sa, 6z6l:Sa, 6z6m:Sa, 6z6n:Sa, 7zjw:SF, 7zjx:SF, 6zlw:c, 6zm7:Sa, 6zme:Sa, 6zmi:Sa, 6zmo:Sa, 6zmw:Q, 6zn5:c, 6zoj:a, 6zok:a, 6zon:Q, 6zp4:Q, 6zv6:a, 6zvh:a, 6zvj:Q, 6zvk:O3, 6zxg:h, 6zxh:h
5 7olc:Sa 104 95 0.6735 0.6346 0.6947 4.21e-45 7old:Sa, 8oo0:Sa, 7r81:b2, 7z3n:Sa, 7z3o:Sa
6 9bh5:Aa 99 97 0.6633 0.6566 0.6701 1.17e-44 9cai:Aa
7 7pzy:b 100 96 0.6735 0.6600 0.6875 6.52e-43 8c3a:c, 8c3a:DN, 8cq7:c, 8cq7:DN, 8cqw:c, 8cqw:DN, 8cre:c, 8cre:DN, 8oeq:c, 8oeq:DN, 7q08:b, 7q0f:b, 7q0p:b, 7q0r:b, 8q5i:b
8 6fyx:a 103 96 0.6429 0.6117 0.6562 3.39e-41 7a1g:e, 7b7d:e, 8bn3:D6, 8bqd:e, 8bqx:e, 8cah:e, 8cas:e, 8ccs:2, 8cdl:2, 8cdr:2, 8ceh:2, 8cf5:2, 8cg8:2, 8cgn:2, 8civ:2, 8cku:2, 8cmj:2, 5dat:D6, 5dat:d6, 5dc3:D6, 5dc3:d6, 5dge:D6, 5dge:d6, 5dgf:D6, 5dgf:d6, 5dgv:D6, 5dgv:d6, 8eub:Ba, 8evp:Ba, 8evq:Ba, 8evr:Ba, 8evs:Ba, 8evt:Ba, 8ewb:Ba, 8ewc:Ba, 5fci:D6, 5fci:d6, 5fcj:D6, 5fcj:d6, 6fyy:a, 6gq1:AQ, 6gqb:AQ, 6gqv:AQ, 6gsm:a, 6gsn:a, 6hhq:b, 6hhq:d6, 5i4l:D6, 5i4l:d6, 6i7o:e, 6i7o:eb, 8i7j:a, 5it7:a, 5it9:a, 3j6x:26, 3j6y:26, 3j77:26, 3j78:26, 3j80:a, 3j81:a, 3jam:a, 3jap:a, 5juo:XB, 5jup:XB, 5jus:XB, 5jut:XB, 5juu:XB, 8k2d:Sa, 8k82:Sa, 5ll6:e, 5lyb:D6, 5lyb:d6, 5m1j:a2, 5mc6:e, 5mei:d6, 5mei:b, 7mpi:Ba, 7mpj:Ba, 7n8b:Ba, 5ndg:D6, 5ndg:d6, 5ndv:D6, 5ndv:d6, 5ndw:D6, 5ndw:d6, 7nrc:Se, 7nrd:Se, 5obm:D6, 5obm:d6, 5on6:d6, 5on6:b, 7osa:eS26, 7osm:eS26, 6q8y:e, 7rr5:Sa, 8rw1:a, 6s47:Bb, 8s8d:a, 8s8e:a, 8s8f:a, 8s8g:a, 8s8h:a, 8s8i:a, 8s8j:a, 6snt:a, 6sv4:e, 6sv4:eb, 6sv4:ec, 6t4q:Sa, 6t7i:Sa, 6t7t:Sa, 6t83:ab, 6t83:1, 5tbw:b, 5tbw:d6, 6tb3:e, 5tga:D6, 5tga:d6, 5tgm:D6, 5tgm:d6, 6tnu:e, 4u3m:D6, 4u3m:d6, 4u3n:D6, 4u3n:d6, 4u3u:D6, 4u3u:d6, 4u4n:D6, 4u4n:d6, 4u4o:D6, 4u4o:d6, 4u4q:D6, 4u4q:d6, 4u4r:D6, 4u4r:d6, 4u4u:D6, 4u4u:d6, 4u4y:D6, 4u4y:d6, 4u4z:D6, 4u4z:d6, 4u50:D6, 4u50:d6, 4u51:D6, 4u51:d6, 4u52:D6, 4u52:d6, 4u53:D6, 4u53:d6, 4u55:D6, 4u55:d6, 4u56:D6, 4u56:d6, 4u6f:D6, 4u6f:d6, 4uer:5, 6uz7:a, 4v88:Aa, 4v88:Ca, 4v8y:A0, 4v8z:A0, 4v92:Ba, 6woo:aa, 6xiq:AQ, 6xir:AQ, 8y0u:Sa, 6z6j:Sa, 6z6k:Sa, 6zce:b, 7zpq:Aa, 7zrs:Aa, 6zu9:e, 7zuw:Aa, 7zux:Da, 6zvi:K, 7zw0:se
9 5xxu:a 99 96 0.6429 0.6364 0.6562 3.95e-40
10 6zj3:Sb 97 97 0.6531 0.6598 0.6598 3.76e-39
11 3j7a:3 95 93 0.6224 0.6421 0.6559 1.68e-38 3jbn:3, 3jbo:3, 3jbp:3, 6okk:c, 8tpu:S3
12 8btd:Sd 108 96 0.5816 0.5278 0.5938 4.76e-37 8br8:Sd, 8brm:Sd, 8bsi:Sd, 8bsj:Sd, 8btr:Sd, 8fvy:a, 8g4s:a, 7pwf:a, 7pwo:a1
13 6zu5:SAA 97 95 0.5102 0.5155 0.5263 5.53e-30
14 4bts:A5 100 98 0.4694 0.4600 0.4694 4.39e-28 4bts:B5, 4bts:C5, 4bts:D5, 4v5o:A5, 4v5o:B5
15 8p5d:SAA 101 95 0.4490 0.4356 0.4632 8.06e-28 8p60:SAA, 8p60:RAA, 7qca:SAA
16 7qep:D6 101 91 0.4388 0.4257 0.4725 3.52e-25
17 5xyi:a 100 79 0.4082 0.4000 0.5063 7.19e-25
18 6rm3:SAA 97 92 0.4388 0.4433 0.4674 7.31e-25
19 8ova:AV 103 98 0.4694 0.4466 0.4694 7.73e-25 8ove:AV, 4v8m:AV
20 8rxh:Sb 104 98 0.4898 0.4615 0.4898 8.22e-24 8a3w:Sb, 8a98:Sb, 6az1:b, 8ovj:Sb, 8rxx:Sb, 5t2a:AV
21 7ase:t 104 98 0.4592 0.4327 0.4592 4.09e-23 5opt:T
22 3ps9:A 668 40 0.1122 0.0165 0.2750 0.19 3awi:A, 3awi:B, 3awi:C, 3awi:D, 3awi:E, 3awi:F
23 3pvc:A 635 61 0.1735 0.0268 0.2787 0.23 3sgl:A
24 4hjw:C 378 61 0.2041 0.0529 0.3279 0.83 4hjw:A, 4hjw:B
25 8p2f:E 670 72 0.1837 0.0269 0.2500 1.2 8p2g:E, 8p2h:E
26 5cde:A 398 55 0.2041 0.0503 0.3636 2.0 5cde:B, 5fcf:A, 5fcf:B, 5fch:A, 5fch:B, 4r60:A, 4r60:B
27 1tq6:A 402 22 0.0918 0.0224 0.4091 2.8 5fph:A, 5fph:B, 5fph:C, 5fph:D, 5fph:E, 5fph:F, 5fph:G, 4lv5:B, 4lv8:B, 1tpz:A, 1tpz:B, 1tq2:A, 1tq2:B, 1tq4:A
28 7wnh:D 316 31 0.1020 0.0316 0.3226 4.2 8cyo:A, 6dda:B, 6dda:A, 6dda:C, 6l6l:A, 6l6l:B, 6l6q:A, 6l6q:B, 7wnh:A, 7wnh:C, 7wnh:B, 5y41:A, 5y41:B, 5yd6:A, 5yd6:B, 5yd6:C, 5yd6:D
29 5wbj:A 1058 43 0.1429 0.0132 0.3256 5.0 5wbk:A, 5wbl:A
30 6y9c:A 365 55 0.1429 0.0384 0.2545 5.9 6y8s:A, 6y9d:A, 6y9d:B, 6y9d:C, 6y9d:D, 6y9d:E, 6y9d:F, 6y9d:G, 6y9d:H, 6y9d:I, 6y9d:J, 6y9d:K, 6y9d:L, 6zgp:A, 6zgp:B, 6zgp:C, 6zgp:D, 6zgp:E, 6zgp:F, 6zgp:G, 6zgp:H, 6zgp:I, 6zgp:J, 6zgp:K, 6zgp:L
31 6y8j:A 343 55 0.1429 0.0408 0.2545 6.6
32 4hk5:D 380 61 0.1735 0.0447 0.2787 6.8 4hk5:A, 4hk5:B, 4hk5:C, 4hk6:A, 4hk6:B, 4hk6:C, 4hk6:D, 4hk7:A, 4hk7:B, 4hk7:C, 4hk7:D, 4lak:A, 4lak:B, 4lal:A, 4lal:B, 4lal:C, 4lal:D, 4lam:A, 4lam:B, 4lao:A, 4lao:B

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
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