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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
LSAEIINRQATINIGTIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEFKSDKEISPKCQRPGCP
GRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESAL
EHQKSILKFIRGTIADGAPIVPISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGG
SILNGVFKLGDEIEIRPGIVTDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVGTKVDPTLCRADRLVGQVVGAKG
HLPNIYTDIEINYFLLRRLLGVKKQAKVRKLEPNEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRI
EKHWRLIGWATIKK

The query sequence (length=414) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 8rw1:k 470 430 1.0000 0.8809 0.9628 0.0 6fyx:k, 6gsm:k, 6gsn:k, 6qg0:M, 6qg0:N, 6qg1:M, 6qg1:N, 6qg2:M, 6qg3:M, 6qg5:M, 6qg6:M, 6qg6:N, 8s8d:k, 8s8e:k, 8s8g:k, 8s8h:k, 8s8i:k, 8s8j:k
2 8cas:G 396 406 0.9565 1.0000 0.9754 0.0 6fyy:k, 6i3m:O, 6i3m:P, 6i7t:O, 6i7t:P, 3jap:k, 8s8f:k
3 3j81:k 365 406 0.8816 1.0000 0.8990 0.0
4 8pj1:t 472 434 0.7560 0.6631 0.7212 0.0 7d43:P, 6fec:S, 5k0y:S, 6k71:P, 6k72:P, 8oz0:E, 8pj2:t, 8ppl:It, 6yal:B, 6yam:B, 6yan:B
5 8qzz:A 433 429 0.7029 0.6721 0.6783 0.0 7a09:Y, 6zp4:Y
6 7qp6:t 356 410 0.6763 0.7865 0.6829 0.0 7qp7:t, 6ybv:t, 6zmw:t
7 7ase:5 421 424 0.5072 0.4988 0.4953 3.08e-143
8 1s0u:A 391 405 0.4807 0.5090 0.4914 5.67e-134
9 2dcu:A 407 408 0.4638 0.4717 0.4706 1.52e-132 2d74:A, 1kjz:A, 1kk0:A, 1kk1:A, 1kk2:A, 1kk3:A
10 3qsy:A 415 409 0.4348 0.4337 0.4401 1.71e-121 2aho:A, 3cw2:B, 6i5m:A, 5jb3:7, 5jbh:7, 4m0l:A, 4m0l:B, 4m0l:C, 4m0l:D, 4m0l:E, 4m0l:F, 4m2l:A, 4m4s:A, 4nbs:A, 3pen:A, 2pmd:A, 2pmd:B, 4qfm:A, 4qhy:A, 2qmu:A, 2qn6:A, 6r8s:A, 6r8t:A, 4rcy:A, 4rcz:A, 4rd0:A, 4rd1:A, 4rd2:A, 4rd3:A, 4rd4:A, 4rd6:A, 4rjl:A, 3sjz:A, 6sw9:7, 6swc:7, 3v11:A
11 5lzb:z 614 386 0.2343 0.1580 0.2513 3.55e-20 5lzc:z, 5lzd:z, 2pjp:A
12 1b23:P 405 298 0.2005 0.2049 0.2785 6.27e-20 2c77:A, 2c78:A, 1eft:A, 1exm:A, 4h9g:A, 1ha3:A, 4lbv:A, 4lbw:A, 4lby:A, 4lbz:A, 4lc0:A, 1mj1:A, 1ob5:A, 1ob5:C, 1ob5:E, 2p8w:S, 2p8x:S, 2p8z:S, 1ttt:A, 1ttt:B, 1ttt:C, 1tui:A, 1tui:B, 1tui:C, 4v5l:AZ, 4v8q:BZ
13 1d2e:A 397 276 0.1884 0.1965 0.2826 1.75e-19 7a5g:Z, 1d2e:B, 1d2e:C, 1d2e:D, 7o9k:t
14 4v5p:AZ 385 284 0.1884 0.2026 0.2746 2.70e-19 1ha3:B, 4v5g:AZ, 4v5g:CZ, 4v5p:CZ, 4v5q:AZ, 4v5q:CZ, 4v5r:AZ, 4v5r:CZ, 4v5s:AZ, 4v5s:CZ, 4v68:AZ
15 6gfu:A 386 354 0.2271 0.2435 0.2655 5.41e-19 5w76:A, 5w7q:A
16 5izm:B 495 256 0.1836 0.1535 0.2969 1.21e-18 5izk:A, 5izm:A
17 8v9l:x 387 270 0.1763 0.1886 0.2704 1.48e-18 7vok:A, 7vok:B, 7vok:C, 7vok:D
18 6htw:B 385 276 0.1957 0.2104 0.2935 4.68e-18 6htw:H, 6i8r:A
19 5w75:C 387 278 0.1884 0.2016 0.2806 8.38e-18 5w75:B, 5w75:D, 5w75:A
20 7paj:9 393 281 0.1957 0.2061 0.2883 1.87e-17 7pak:9, 7pha:9, 7pi9:9, 7pip:9
21 7zjw:E 519 267 0.1812 0.1445 0.2809 5.82e-17 5izl:A, 5izl:B
22 1ob2:A 393 269 0.1884 0.1985 0.2900 1.33e-16 1d8t:A, 1d8t:B, 1dg1:G, 1dg1:H, 1efc:A, 1efc:B, 6eze:A, 6eze:B, 8fr3:A, 8fr3:B, 2fx3:A, 4g5g:A, 8g7p:z, 8g7q:z, 5jbq:A, 5mi3:A, 5mi3:B, 5mi8:A, 5mi8:B, 5mi9:A, 5mi9:B, 4p3y:A, 8qfs:C, 8qhc:C, 3u2q:A, 3u6k:A, 3u6k:B, 5uyk:Z, 5uyl:Z, 5uym:Z, 5uyn:Z, 5uyp:Z, 5uyq:Z, 4v69:AZ, 4v6k:BC, 4v6l:AC, 5wdt:z, 6wd2:8, 6wd3:8, 6wd5:8, 6wd6:8, 6wd8:8, 5we4:z, 5we6:z, 5wf0:z, 5wfk:z, 5wfs:z
23 4iw3:B 380 264 0.1812 0.1974 0.2841 4.94e-16 4iw3:K, 4j0q:A, 4j0q:B, 4j0q:C, 4j0q:D, 4j0q:E
24 4ac9:C 471 254 0.1473 0.1295 0.2402 7.71e-16 4ac9:A, 4ac9:B, 4aca:B, 4aca:C, 4acb:A, 4acb:B, 4acb:C
25 3avt:A 1203 256 0.1787 0.0615 0.2891 8.00e-16 7abz:6, 5afi:z, 3agp:A, 3agq:A, 3avu:A, 3avv:A, 3avw:A, 3avx:A, 3avy:A, 7bbn:A, 7bbn:B, 2bvn:A, 2bvn:B, 1efm:A, 1etu:A, 4fwt:A, 2hcj:A, 2hcj:B, 2hdn:A, 2hdn:B, 2hdn:C, 2hdn:D, 2hdn:E, 2hdn:F, 2hdn:G, 2hdn:H, 2hdn:I, 2hdn:J, 2hdn:K, 2hdn:L, 5i4r:C, 5i4r:D, 5i4r:G, 5i4r:H, 3mmp:G, 5opd:A, 5opd:B, 4pc2:A, 4pc2:B, 4pc3:A, 4pc3:B, 4pc6:A, 4pc6:B, 4pc7:A, 3u6b:B, 3u6b:A, 3vnu:A, 3vnv:A, 6wd4:8, 6wd7:8, 6wd9:8, 6wda:8
26 4zv4:A 392 272 0.1787 0.1888 0.2721 8.75e-16 4zv4:B
27 8rdw:H 386 270 0.1908 0.2047 0.2926 1.10e-15 8rd8:H
28 6mij:A 388 267 0.1812 0.1933 0.2809 4.73e-15
29 7vmx:B 359 255 0.1715 0.1978 0.2784 3.74e-14
30 4zu9:A 582 272 0.1570 0.1117 0.2390 1.81e-12
31 6ji2:A 432 382 0.2126 0.2037 0.2304 1.28e-11 4cxg:A, 4cxh:A, 6ji2:E, 3vmf:A, 3wxm:A, 3wxm:C, 3wxm:E, 3wxm:G
32 3wy9:A 416 349 0.2174 0.2163 0.2579 4.21e-11 3wy9:B, 3wya:A
33 1skq:A 416 345 0.2029 0.2019 0.2435 7.72e-11 1jny:A, 1jny:B, 1skq:B
34 5izk:B 451 250 0.1618 0.1486 0.2680 9.21e-10
35 5lzt:jj 428 157 0.1063 0.1028 0.2803 1.04e-06 4d61:i, 5hxb:X, 5hxb:A, 7nwh:jj, 6xk9:X, 6xk9:A
36 1zun:B 394 245 0.1522 0.1599 0.2571 3.07e-06
37 5o8w:A 449 197 0.1280 0.1180 0.2690 6.02e-06 2b7b:A, 9bdp:EF1A, 1g7c:A, 1ije:A, 1ijf:A
38 1g7s:A 576 143 0.0942 0.0677 0.2727 3.01e-05 1g7t:A
39 5lmv:a 502 283 0.1546 0.1275 0.2261 3.32e-05
40 4v6w:Az 837 169 0.1184 0.0585 0.2899 1.46e-04
41 8cf5:Aa 842 154 0.1184 0.0582 0.3182 1.54e-04 8cdr:Aa, 8ceh:Aa, 8cg8:Aa, 8civ:Aa, 8cku:Aa, 8cmj:Aa, 2e1r:A, 8eub:DC, 8evq:DC, 8evr:DC, 8evs:DC, 8ewb:DC, 6gq1:AZ, 6gqb:AZ, 6gqv:AX, 5it7:1, 5juo:DC, 5jup:DC, 5jus:DC, 5jut:DC, 5juu:DC, 8k2d:CD, 1n0u:A, 2npf:A, 2npf:B, 7osa:eEF2, 7osm:eEF2, 2p8w:T, 2p8x:T, 2p8y:T, 2p8z:T, 1u2r:A, 4v4b:AT, 1zm2:E
42 7unv:x 593 141 0.0966 0.0675 0.2837 1.94e-04 7unq:x, 7unr:x, 7unt:x, 7unu:x, 7unw:x
43 7yyp:A 597 146 0.0918 0.0637 0.2603 4.68e-04 7yzn:A, 7zag:7, 7zah:7, 7zki:7
44 6ra9:B 458 198 0.1111 0.1004 0.2323 8.05e-04 8b6z:A, 4c0s:A, 4c0s:B, 8g5z:EF, 8g60:EF, 8g6j:EF, 5lzs:jj, 6ra9:A, 6zmo:CD
45 4v6v:A1 639 144 0.0821 0.0532 0.2361 0.001
46 8q87:A 857 182 0.1232 0.0595 0.2802 0.002 6d9j:9, 6gz3:Ct, 6gz4:Ct, 6gz5:Ct, 3j7p:4, 7ls1:m, 7ls2:m, 6mtd:v, 6mte:v, 7oyc:v2, 4v6x:Az, 8xsx:CB, 6z6m:CB, 6z6n:CB
47 2lkd:A 178 152 0.0966 0.2247 0.2632 0.003
48 5fg3:A 598 64 0.0556 0.0385 0.3594 0.003 5yt0:A
49 8y0w:CB 768 163 0.1135 0.0612 0.2883 0.005 8y0x:CB
50 3jce:x 586 278 0.1739 0.1229 0.2590 0.009 3deg:C
51 8dmf:A 718 147 0.0870 0.0501 0.2449 0.010 7uvp:A
52 6yxx:EA 532 104 0.0676 0.0526 0.2692 0.016 7aoi:XL, 6yxy:EA
53 5lzw:jj 425 154 0.0894 0.0871 0.2403 0.017 5lzx:jj, 5lzy:jj, 5lzz:jj
54 3j9y:w 639 161 0.0966 0.0626 0.2484 0.034 5kcs:1w
55 2ywf:A 532 244 0.1425 0.1109 0.2418 0.040 2ywg:A, 2ywh:A
56 3p27:B 444 112 0.0725 0.0676 0.2679 0.045 3p27:A
57 5j8b:z 671 212 0.1401 0.0864 0.2736 0.087 5imq:B
58 5imr:C 570 212 0.1401 0.1018 0.2736 0.087
59 5a9y:A 562 140 0.0942 0.0694 0.2786 0.15 5a9x:A
60 5m1j:A6 539 183 0.1063 0.0816 0.2404 0.19
61 5aa0:BZ 605 140 0.0797 0.0545 0.2357 0.27 5a9z:CA, 4zck:A, 4zcl:A, 4zcl:B, 4zcm:A, 4zcm:B
62 8oul:A 185 209 0.1184 0.2649 0.2344 0.30 8ouk:A, 8oul:B, 8oul:C
63 5anb:K 1120 185 0.1039 0.0384 0.2324 0.34 5anc:K
64 4crn:P 430 52 0.0386 0.0372 0.3077 0.35
65 4rxu:A 340 75 0.0556 0.0676 0.3067 0.36
66 8hl1:AEFG 725 170 0.1135 0.0648 0.2765 0.49 8hl2:AEFG, 8hl3:AEFG, 8hl4:AEFG
67 9ax8:z 509 43 0.0362 0.0295 0.3488 0.49 3jcj:f, 3jcn:b, 5me0:W, 5me1:W, 6o7k:f, 6o9k:z
68 6j6g:C 920 127 0.0700 0.0315 0.2283 0.76 7b9v:C, 6bk8:B, 7dco:C, 5gm6:C, 5gmk:C, 6j6h:C, 6j6n:C, 6j6q:C, 3jcm:H, 6teo:A, 6teo:C, 5wsg:C, 5y88:C, 5ylz:C, 5zwm:C, 5zwo:C
69 5lj3:C 882 127 0.0700 0.0329 0.2283 0.79 6exn:C, 5gam:C, 5gan:C, 5lj5:C, 5lqw:B, 5mps:C, 5mq0:C, 5nrl:C
70 7pua:IA 704 43 0.0362 0.0213 0.3488 1.6 7pub:IA
71 7old:C 813 142 0.0918 0.0467 0.2676 1.6
72 3wnb:A 361 333 0.1667 0.1911 0.2072 1.7 3wnc:A
73 4v9h:AY 622 140 0.0821 0.0547 0.2429 1.8
74 6gaw:BC 571 113 0.0700 0.0508 0.2566 2.8 6gaz:BC, 6gb2:BC, 7po2:7, 8qrn:7, 6rw5:7
75 6m5r:B 689 43 0.0362 0.0218 0.3488 2.8 6m5s:B, 6m5u:B, 6m5v:B
76 2okj:B 504 62 0.0411 0.0337 0.2742 3.2 2okj:A, 3vp6:A, 3vp6:B
77 3ieu:A 293 120 0.0845 0.1195 0.2917 3.3 3ieu:B
78 7oyd:v 726 150 0.0870 0.0496 0.2400 3.8
79 3izy:P 537 66 0.0483 0.0372 0.3030 4.6
80 8bsi:a 815 173 0.1063 0.0540 0.2543 6.0
81 3tr5:A 518 66 0.0411 0.0328 0.2576 6.8 3tr5:B, 3tr5:C, 3tr5:D
82 1eil:A 289 68 0.0483 0.0692 0.2941 9.5 1dhy:A, 1eiq:A, 1eir:A, 1kw3:B, 1kw6:B, 1kw8:B, 1kw9:B, 1kwc:B
83 7syv:x 627 140 0.0821 0.0542 0.2429 9.9 8pj3:0, 8pj4:0, 8pj5:0, 7syw:x, 7syx:x, 7tql:1, 4ujc:AB, 4ujd:BB

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218