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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
EVKIMVEKDPVKTSFEKWAKPGHFSRTLAKGPNTTTWIWNLHADAHDFDSHTNDLEEISRKVFSAHFGQLAVIFIWLSGM
YFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQKILNGDVGGGFQGIQITSGFFQLWRASGITSELQLYTTAIGGLIFAA
LMLFAGWFHYHKAAPKLAWFQNVESMLNHHLAGLLGLGSLAWAGHQVHVSLPINRLLDAGVDPKEIPLPHEFILNRDLLA
QLYPSFSKGLTPFFTLNWSEYSDFLTFRGGLNPVTGGLWLTDTAHHHLAIAVLFLVAGHMYRTNFGIGHSMKEILEAHKG
PFTGEGHKGLYEILTTSWHAQLAINLAMLGSLTIIVAHHMYAMPPYPYLATDYATQLSLFTHHMWIGGFLVVGAAAHAAI
FMVRDYDPTTQYNNLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTH
ALAPSLTAPNATASTSLTWGGGDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLG
FRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDF
LWAQASQVIQSYGSSLSAYGLLFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPAIQPRALSIVQGRAVGVA
HYLLGGIATTWAFFLARIISVG

The query sequence (length=742) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 5l8r:A 743 742 0.9259 0.9246 0.9259 0.0 8bcv:A, 8bcw:A, 7dkz:A, 7ew6:A, 7ewk:A, 7f9o:A, 7f9o:e, 8htu:A, 8j6z:A, 8j7a:A, 8j7b:A, 7ksq:A, 7kux:A, 6l35:A, 3lw5:A, 2o01:A, 4rku:A, 7wfd:AA, 7wfe:BA, 7wg5:AA, 7wg5:BA, 8wgh:A, 2wsc:A, 2wse:A, 2wsf:A, 4xk8:A, 4xk8:a, 7xqp:A, 4y28:A, 6yac:A, 6yez:A, 5zji:A, 6zoo:A, 6zxs:A
2 7yca:A 742 741 0.8868 0.8868 0.8880 0.0 7a4p:A, 7bgi:A, 7blx:A, 8cmo:A, 7d0j:A, 7dz7:A, 7dz8:A, 8h2u:A, 6ijj:A, 6ijo:A, 6jo5:A, 6jo6:A, 7r3k:A, 7wyi:A, 7wzn:A, 7zq9:A, 7zqc:A, 7zqd:A, 7zqd:A2, 6zzx:A, 6zzy:A
3 7y5e:AN 745 742 0.8666 0.8631 0.8666 0.0 7y5e:A2, 7y7a:A7, 7y7a:Ao
4 6igz:A 740 742 0.8612 0.8635 0.8612 0.0 6qph:A, 6rhz:A, 6sl5:A, 6yxr:A
5 8wm6:A 742 742 0.8504 0.8504 0.8504 0.0 8wmj:A, 8wmv:A, 8wmw:A, 7y7b:A, 7y8a:A
6 7dr0:A 739 740 0.8437 0.8471 0.8459 0.0 7dr1:A, 7dr2:aA, 7dr2:bA, 7dr2:cA, 7dr2:dA
7 6tra:A 746 746 0.8625 0.8579 0.8579 0.0 4fe1:A, 7fix:A1, 7fix:A2, 7fix:A3, 1jb0:A, 6k33:aA, 6k33:bA, 6k33:cA, 6lu1:A, 7m75:A, 7m76:A, 7m78:A, 3pcq:A, 6pfy:A, 6pfy:G, 6pfy:Y, 6pgk:A, 6pgk:G, 6pgk:Y, 6trc:A, 6trc:a, 6trc:1, 6trd:A, 6trd:a, 6trd:1, 5zf0:A1, 5zf0:A2, 5zf0:A3, 5zf0:A4, 5zf0:A6, 5zf0:A5
8 7blz:A 743 730 0.8464 0.8452 0.8603 0.0 6fos:A, 8wey:A, 5zgb:A, 5zgh:A
9 6ly5:a 742 741 0.8288 0.8288 0.8300 0.0 6l4u:A
10 6k61:A 742 742 0.8261 0.8261 0.8261 0.0 6jeo:aA, 6jeo:bA, 6jeo:cA, 6jeo:dA, 6k61:a, 6tcl:A1, 6tcl:A2, 6tcl:A, 6tcl:AA, 7y3f:A
11 5oy0:A 751 742 0.8315 0.8216 0.8315 0.0 8am5:a, 8asl:a, 8asp:a, 6hqb:A, 4kt0:A, 4l6v:A, 4l6v:a, 4l6v:1, 6nwa:A, 6nwa:a, 6nwa:H, 7o1v:A, 5oy0:a, 5oy0:1, 7umh:A, 7umh:H, 7umh:a, 6uzv:A, 6uzv:a, 6uzv:1, 6vpv:A, 6vpv:a, 6vpv:1
12 6kif:A 751 754 0.8410 0.8309 0.8276 0.0 6kif:G, 6kif:e, 6kig:A, 6kig:G, 6kig:e
13 7qco:A 728 729 0.8154 0.8310 0.8299 0.0 7qco:E, 7qco:e, 7qco:a
14 6kmw:aA 721 723 0.7951 0.8183 0.8160 0.0 6kmw:bA, 6kmw:cA
15 7s3d:A 749 746 0.7722 0.7650 0.7681 0.0 7s3d:G, 7s3d:a
16 7dwq:A 726 725 0.7291 0.7452 0.7462 0.0
17 7lx0:G 751 754 0.7790 0.7696 0.7666 0.0 7lx0:a, 7lx0:A, 6pnj:A, 6pnj:G, 6pnj:a
18 7coy:aA 685 714 0.7022 0.7606 0.7297 0.0 7coy:bA, 7coy:cA
19 7f4v:aA 772 774 0.7399 0.7111 0.7093 0.0 7f4v:bA, 7f4v:cA
20 6kmx:aA 717 718 0.7116 0.7364 0.7354 0.0 6kmx:bA, 6kmx:cA
21 8jjr:a 665 726 0.4798 0.5353 0.4904 0.0
22 8jze:a 670 725 0.4582 0.5075 0.4690 0.0 8jzf:a
23 6kmw:aB 740 765 0.4838 0.4851 0.4693 0.0 6kmw:cB, 6kmw:bB
24 7blz:B 731 751 0.4757 0.4829 0.4700 0.0 6fos:B, 8wey:B, 5zgb:B, 5zgh:B
25 8jw0:a 645 716 0.4865 0.5597 0.5042 0.0
26 7f4v:aB 725 748 0.4717 0.4828 0.4679 0.0 7f4v:bB, 7f4v:cB
27 6igz:B 733 754 0.4771 0.4829 0.4695 0.0
28 6kif:B 733 755 0.4811 0.4870 0.4728 0.0 6kif:H, 6kif:f, 6kig:B, 6kig:H, 6kig:f
29 6ly5:b 732 753 0.4690 0.4754 0.4622 0.0 6l4u:B
30 7d0j:B 734 753 0.4677 0.4728 0.4608 0.0 7a4p:B, 7bgi:B, 7blx:B, 8cmo:B, 7dz7:B, 7dz8:B, 8h2u:B, 6ijj:B, 6ijo:B, 6jo5:B, 6jo6:B, 6qph:B, 7r3k:B, 6rhz:B, 6sl5:B, 7wyi:B, 7wzn:B, 6yxr:B, 7zq9:B, 7zqc:B, 7zqd:B, 7zqd:B2, 6zzx:B, 6zzy:B
31 7yca:B 732 752 0.4650 0.4713 0.4588 0.0
32 7s3d:B 742 762 0.4623 0.4623 0.4501 0.0 7s3d:H, 7s3d:b
33 7fix:B1 740 761 0.4757 0.4770 0.4639 0.0 7bw2:B, 4fe1:B, 7fix:B2, 7fix:B3, 1jb0:B, 6k33:aB, 6k33:bB, 6k33:cB, 7m75:B, 7m76:B, 7m78:B, 3pcq:B, 6pfy:H, 6pfy:B, 6pfy:Z, 6pgk:H, 6pgk:B, 6pgk:Z, 6tra:B, 6trc:B, 6trc:b, 6trc:2, 6trd:B, 6trd:b, 6trd:2, 5zf0:B1, 5zf0:B2, 5zf0:B3, 5zf0:B4, 5zf0:B6, 5zf0:B5
34 6vpv:B 737 757 0.4677 0.4708 0.4584 0.0 8am5:b, 8asl:b, 8asp:b, 6hqb:B, 4kt0:B, 4l6v:B, 4l6v:b, 4l6v:2, 6nwa:B, 6nwa:b, 6nwa:G, 7o1v:B, 5oy0:B, 5oy0:b, 5oy0:2, 7umh:B, 7umh:G, 7umh:b, 6uzv:B, 6uzv:b, 6uzv:2, 6vpv:b, 6vpv:2
35 7y5e:BN 732 753 0.4704 0.4768 0.4635 0.0 7y5e:B2, 7y7a:B7, 7y7a:Bo, 7y7b:B, 7y8a:B
36 8wm6:B 732 753 0.4704 0.4768 0.4635 0.0 8wmj:B, 8wmv:B, 8wmw:B
37 7qco:B 734 758 0.4650 0.4700 0.4551 0.0 7qco:G, 7qco:g, 7qco:b
38 6kmx:aB 727 757 0.4596 0.4691 0.4505 0.0 6kmx:bB, 6kmx:cB
39 7wfd:AB 734 754 0.4650 0.4700 0.4576 0.0 8bcv:B, 8bcw:B, 7dkz:B, 7ew6:B, 7ewk:B, 7f9o:B, 7f9o:f, 8htu:B, 8j6z:B, 8j7a:B, 8j7b:B, 7ksq:B, 7kux:B, 6l35:B, 5l8r:B, 3lw5:B, 2o01:B, 4rku:B, 7wfe:BB, 7wg5:AB, 7wg5:BB, 8wgh:B, 2wsc:B, 2wse:B, 2wsf:B, 4xk8:B, 4xk8:b, 7xqp:B, 4y28:B, 6yac:B, 6yez:B, 5zji:B, 6zoo:B, 6zxs:B
40 6k61:B 740 761 0.4663 0.4676 0.4547 0.0 6jeo:aB, 6jeo:bB, 6jeo:cB, 6jeo:dB, 6k61:b, 6tcl:B1, 6tcl:B2, 6tcl:B, 6tcl:BB, 7y3f:B
41 6lu1:B 713 754 0.4582 0.4769 0.4509 0.0
42 7lx0:H 739 764 0.4461 0.4479 0.4332 0.0 7lx0:b, 7lx0:B, 6pnj:H, 6pnj:B, 6pnj:b
43 7dr0:B 706 758 0.4501 0.4731 0.4406 0.0 7dr1:B, 7dr2:aB, 7dr2:bB, 7dr2:cB, 7dr2:dB
44 7dwq:B 659 750 0.4097 0.4613 0.4053 2.10e-177 7coy:aB, 7coy:bB, 7coy:cB
45 8jw0:b 617 705 0.3086 0.3712 0.3248 1.19e-99
46 8jjr:b 659 745 0.3181 0.3581 0.3168 4.06e-98
47 8jze:b 663 724 0.3086 0.3454 0.3163 1.53e-94 8jzf:b
48 7zq9:B2 180 211 0.0916 0.3778 0.3223 3.75e-16
49 5v8k:A 600 224 0.0849 0.1050 0.2812 2.82e-15
50 6m32:A 628 175 0.0633 0.0748 0.2686 0.001 6m32:a
51 8gwa:A 667 175 0.0633 0.0705 0.2686 0.002 8gwa:a, 7uea:A, 7uea:a, 7ueb:A, 7ueb:a, 7z6q:A, 7z6q:a
52 7vzg:a 858 124 0.0431 0.0373 0.2581 0.083 7vzg:A, 7vzr:A, 7vzr:a
53 8abs:A 394 63 0.0283 0.0533 0.3333 0.37 8abr:A, 5ofq:A, 5ofq:B, 5ofq:C, 5ofq:D
54 3bn1:A 368 43 0.0256 0.0516 0.4419 5.3 3bn1:B, 3dr4:A, 3dr4:B, 3dr4:C, 3dr4:D, 3dr7:A, 3dr7:B, 3dr7:C, 3dr7:D
55 7xg0:D 331 95 0.0310 0.0695 0.2421 5.3 7xfz:C, 7xg0:C, 7xg0:E, 7xg0:F, 7xg1:C, 7xg1:D, 7xg1:E, 7xg2:C, 7xg2:D, 7xg2:E, 7xg2:F, 7xg3:C, 7xg3:D, 7xg3:E, 7xg3:F, 7xg4:C, 7xg4:D, 7xg4:E, 7xg4:F

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218