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I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

BioLiP
>protein
EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLL
ARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTL
NGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGP
FGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEM
VSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTA

The query sequence (length=390) is searched through a non-redundant set of database sequences protein_nr.fasta.gz clustered at 90% identity cutoff to identify representative hits. Homologs that belong to the same sequence cluster of the representative hit are listed in the last column of the table.

# Hit Hit
length
Aligned
length
Identity
(normalized by query)
Identity
(normalized by hit)
Identity (normalized
by aligned length)
E-value Homologs
to hit
1 2r0m:A 390 390 0.9974 0.9974 0.9974 0.0 2r0n:A, 1siq:A, 1sir:A
2 3gqt:C 385 391 0.6462 0.6545 0.6445 8.08e-177 3d6b:C, 3eon:C, 3gnc:A, 3gnc:B, 3gnc:C, 3gnc:D, 3gqt:A, 3gqt:B
3 3sf6:A 387 384 0.5077 0.5116 0.5156 1.17e-128
4 2eba:A 380 385 0.5128 0.5263 0.5195 6.83e-126 2eba:D, 2eba:C, 2eba:E, 2eba:F, 2eba:G, 2eba:H, 2eba:I
5 3swo:A 388 375 0.4615 0.4639 0.4800 3.94e-115 3swo:D, 3swo:B, 3swo:C
6 2ix6:A 416 380 0.3590 0.3365 0.3684 3.17e-72 2ix5:A, 2ix5:B, 2ix5:C, 2ix5:D, 2ix6:C, 2ix6:F, 2ix6:B, 2ix6:E, 2ix6:D
7 4l1f:A 380 380 0.3231 0.3316 0.3316 2.47e-63 4l1f:B
8 5lnx:D 374 385 0.3333 0.3476 0.3377 4.78e-61 5lnx:A, 5lnx:B, 5lnx:C, 5lnx:E, 5lnx:F, 5lnx:G, 5lnx:H
9 5ol2:F 378 366 0.3077 0.3175 0.3279 7.03e-57 5ol2:C
10 1buc:A 383 365 0.3051 0.3107 0.3260 1.92e-56 1buc:B
11 2dvl:A 370 371 0.3308 0.3486 0.3477 2.75e-55 2dvl:B
12 7y0a:C 387 371 0.3026 0.3049 0.3181 1.89e-51 1jqi:A, 1jqi:B, 8sgs:A, 8sgs:B, 8sgs:C, 8sgs:D, 2vig:A, 2vig:B, 2vig:C, 2vig:D, 2vig:E, 2vig:F, 2vig:G, 2vig:H, 7y0a:A, 7y0a:B, 7y0a:D, 7y0b:A, 7y0b:B, 7y0b:C, 7y0b:D
13 3owa:C 587 397 0.3205 0.2129 0.3149 2.79e-51 3owa:A, 3owa:B, 3owa:D
14 2z1q:B 549 377 0.3179 0.2259 0.3289 7.54e-51 2z1q:A
15 4n5f:A 378 379 0.2897 0.2989 0.2982 1.17e-48 4n5f:B
16 4kto:A 377 365 0.2974 0.3077 0.3178 7.51e-47 4kto:C, 4kto:B, 4kto:D
17 2jif:A 381 378 0.2795 0.2861 0.2884 4.10e-45 2jif:C, 2jif:B, 2jif:D
18 4m9a:B 376 374 0.2949 0.3059 0.3075 1.63e-44 4m9a:A
19 8sgr:A 393 385 0.2897 0.2875 0.2935 2.53e-44 1ivh:A, 1ivh:B, 1ivh:C, 1ivh:D, 8sgr:B, 8sgr:C, 8sgr:D
20 3mpi:C 395 389 0.2872 0.2835 0.2879 3.57e-44 3mpi:A, 3mpi:B, 3mpi:D, 3mpj:B, 3mpj:A, 3mpj:D, 3mpj:E, 3mpj:F, 3mpj:G
21 1ukw:A 379 376 0.2974 0.3061 0.3085 4.55e-44 1ukw:B
22 7szv:A 372 369 0.2769 0.2903 0.2927 2.32e-42 7szv:B
23 8ca1:B 589 357 0.2821 0.1868 0.3081 7.74e-41 8ca1:A
24 7s7g:A 571 347 0.2846 0.1944 0.3199 1.30e-40 3b96:A, 2uxw:A
25 6fah:D 379 370 0.2923 0.3008 0.3081 1.43e-39 6fah:C
26 2a1t:C 388 377 0.2692 0.2706 0.2785 4.70e-38 2a1t:A, 2a1t:B, 2a1t:D, 1egc:A, 1egc:B, 1egc:C, 1egc:D, 1egd:A, 1egd:B, 1egd:C, 1egd:D, 1ege:A, 1ege:B, 1ege:C, 1ege:D, 4p13:A, 4p13:B, 4p13:C, 4p13:D, 8sgp:A, 8sgp:B, 8sgp:C, 8sgp:D, 1t9g:A, 1t9g:B, 1t9g:C, 1t9g:D
27 7p9a:A 380 384 0.3051 0.3132 0.3099 6.28e-38 7p98:A, 7p98:B, 7p9a:B, 7p9x:A, 7p9x:B, 7p9x:C, 7p9x:D
28 3mdd:A 385 377 0.2667 0.2701 0.2759 1.49e-37 3mdd:B, 3mde:A, 3mde:B, 1udy:A, 1udy:B, 1udy:C, 1udy:D
29 8phe:A 551 354 0.2667 0.1887 0.2938 2.24e-37 8phe:B, 8phf:A, 8phf:B
30 2pg0:A 380 375 0.2718 0.2789 0.2827 7.17e-36 2pg0:B
31 2d29:A 386 376 0.2897 0.2927 0.3005 2.34e-35 2d29:B
32 6es9:A 545 388 0.3026 0.2165 0.3041 3.94e-35 6es9:B
33 7w0j:E 382 376 0.2538 0.2592 0.2633 4.26e-34 8i4p:A, 8i4r:A, 7w0j:B, 7w0j:C, 7w0j:H
34 8w0t:A 398 382 0.2667 0.2613 0.2723 2.15e-33 8w0t:B, 8w0t:C, 8w0t:D, 8w0u:A, 8w0u:B, 8w0u:C, 8w0u:D, 8w0z:A, 8w0z:B, 8w0z:C, 8w0z:D, 8w0z:E, 8w0z:F, 8w0z:G, 8w0z:H
35 3nf4:A 369 364 0.2359 0.2493 0.2527 1.63e-32 3nf4:B
36 4iv6:B 383 379 0.2641 0.2689 0.2718 4.40e-32 4iv6:A
37 3pfd:C 369 372 0.2462 0.2602 0.2581 7.00e-32 3pfd:A, 3pfd:B, 3pfd:D
38 1rx0:A 384 362 0.2564 0.2604 0.2762 6.79e-31 1rx0:C, 1rx0:B, 1rx0:D
39 5idu:C 405 354 0.2615 0.2519 0.2881 6.49e-29 5idu:A, 5idu:B, 5idu:D
40 6af6:A 383 340 0.2308 0.2350 0.2647 3.64e-28 5zw2:A, 5zw7:A, 5zw8:A
41 4irn:A 378 376 0.2385 0.2460 0.2473 6.86e-28 4irn:B, 4irn:C, 4irn:D, 4irn:E, 4irn:F, 4irn:G, 4irn:H
42 7xp7:B 376 365 0.2744 0.2846 0.2932 5.30e-27 7xp7:A, 7xp7:C, 7xp7:D
43 5jsc:A 388 288 0.2103 0.2113 0.2847 4.74e-25 5jsc:B, 5jsc:C, 5jsc:D
44 3r7k:A 378 368 0.2359 0.2434 0.2500 1.07e-20 3r7k:B, 3r7k:C, 3r7k:D
45 1r2j:A 353 262 0.1923 0.2125 0.2863 1.34e-20
46 3oib:A 381 372 0.2487 0.2546 0.2608 3.72e-19 3oib:B, 3p4t:A, 3p4t:B
47 8ciw:A 555 403 0.2564 0.1802 0.2481 1.99e-18 8ciw:B
48 6cxt:B 372 283 0.1795 0.1882 0.2473 1.08e-14 6cy8:B
49 5af7:B 391 300 0.1949 0.1944 0.2533 3.39e-13 5af7:A, 5ahs:A, 5ahs:B, 5ahs:C, 5ahs:E, 5ahs:F, 5ahs:D
50 6u1v:B 389 280 0.1846 0.1851 0.2571 8.56e-13 6u1v:A, 6u1v:C, 6u1v:D
51 5ez3:B 541 277 0.1923 0.1386 0.2708 6.03e-12 5ez3:A, 5ez3:C, 5ez3:D
52 4hr3:A 407 297 0.1846 0.1769 0.2424 5.01e-11
53 6wy8:B 384 191 0.1385 0.1406 0.2827 3.12e-10 6wy8:D, 6wy9:A
54 2wbi:B 398 325 0.1974 0.1935 0.2369 1.17e-09 2wbi:A
55 4x28:A 386 162 0.1231 0.1244 0.2963 1.79e-09 4x28:B
56 8hk0:B 379 207 0.1487 0.1530 0.2802 6.14e-08 8hk0:A
57 6wy8:C 364 253 0.1718 0.1841 0.2648 8.56e-08 6wy8:A, 6wy9:B
58 5y9d:A 687 225 0.1410 0.0801 0.2444 2.91e-07 5y9d:B
59 5ys9:A 692 357 0.2205 0.1243 0.2409 8.79e-07 5ys9:B
60 6sd8:X 503 280 0.1744 0.1352 0.2429 1.22e-06 6sd8:A, 6sda:A, 6sda:B
61 4zyj:D 392 203 0.1410 0.1403 0.2709 2.00e-06 4zyj:A, 4zyj:B, 4zyj:C
62 4xvx:B 373 290 0.1769 0.1850 0.2379 3.25e-06 4xvx:A
63 2fon:B 656 151 0.0949 0.0564 0.2450 3.29e-06 2fon:A, 2fon:C
64 3u33:A 540 288 0.1769 0.1278 0.2396 3.78e-06 3djl:A, 3u33:B, 3u33:C, 3u33:D, 3u33:E, 3u33:F, 3u33:G, 3u33:H, 3u33:I, 3u33:J, 3u33:K, 3u33:L
65 5z8t:A 395 250 0.1615 0.1595 0.2520 9.82e-06 5z8t:B, 5z8t:C
66 6kse:A 607 327 0.1974 0.1269 0.2355 4.75e-05 6kse:B
67 5k3j:A 662 161 0.0897 0.0529 0.2174 7.17e-05 5k3j:B
68 1w07:B 658 226 0.1359 0.0805 0.2345 9.54e-05 1w07:A
69 4x28:D 364 190 0.1205 0.1291 0.2474 1.81e-04 4x28:C
70 1is2:A 637 162 0.0923 0.0565 0.2222 0.015 2ddh:A, 1is2:B
71 5k3i:A 661 70 0.0462 0.0272 0.2571 0.019 5k3i:B, 5k3i:C, 5k3i:D, 5k3i:E, 5k3i:F, 5k3i:G, 5k3i:H
72 6ksa:B 611 193 0.1231 0.0786 0.2487 0.046 6kpt:A, 6kpt:B, 6kri:A, 6kri:B, 6ks9:A, 6ks9:B, 6ksa:A, 6ksb:A, 6ksb:B, 6lpy:A, 6lpy:B, 6lq0:A, 6lq0:B, 6lq1:A, 6lq1:B, 6lq2:A, 6lq2:B, 6lq3:A, 6lq3:B, 6lq4:A, 6lq4:B, 6lq5:A, 6lq5:B, 6lq6:A, 6lq6:B, 6lq7:A, 6lq7:B, 6lq8:A, 6lq8:B
73 7q86:A 612 139 0.0872 0.0556 0.2446 0.053 7q86:B
74 3x0y:A 402 369 0.2231 0.2164 0.2358 0.076 3x0y:F, 3x0y:C, 3x0y:E, 3x0y:B, 3x0y:D
75 4kcf:A 407 160 0.0949 0.0909 0.2313 0.095 3m9v:A
76 5kat:A 165 88 0.0667 0.1576 0.2955 1.9 5kau:A, 5kaw:A, 5kcb:A
77 2vfa:B 205 52 0.0359 0.0683 0.2692 2.1 2vfa:A
78 1j49:A 332 44 0.0436 0.0512 0.3864 4.3 1j49:B
79 4go4:A 487 68 0.0462 0.0370 0.2647 7.6 4go4:B, 4go4:C, 4go4:D, 4go4:E, 4go4:F, 4go4:G, 4go4:H
80 7ck2:A 352 66 0.0615 0.0682 0.3636 8.2 7ck2:B
81 1yvl:B 653 44 0.0436 0.0260 0.3864 9.6 1bf5:A, 7nuf:A, 1yvl:A
82 8cmo:9 184 51 0.0385 0.0815 0.2941 9.7

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Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).
  • yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218