2v0m A 2.8 BS01 HEM A 1 R105 I118 W126 R130 A305 T309 I369 R375 P434 F435 R440 N441 C442 I443 F447 A448 R76 I89 W97 R101 A262 T266 I326 R332 P391 F392 R397 N398 C399 I400 F404 A405 T309 F435 C442 T266 F392 C399 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 P08684 16954191 1499 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 2v0m A 2.8 BS02 KLN A 1 F57 S119 L210 F304 R372 E374 G481 L482 F28 S90 L181 F261 R329 E331 G438 L439 T309 F435 C442 T266 F392 C399 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1500 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 2v0m A 2.8 BS03 KLN A 2 F57 R106 F108 S119 F213 L216 L221 T224 I301 F28 R77 F79 S90 F184 L187 L192 T195 I258 T309 F435 C442 T266 F392 C399 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1501 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 2v0m B 2.8 BS01 HEM B 1 R105 I118 W126 R130 F302 A305 T309 R375 P434 F435 G436 R440 N441 C442 I443 F447 R76 I89 W97 R101 F257 A260 T264 R330 P389 F390 G391 R395 N396 C397 I398 F402 T309 F435 C442 T264 F390 C397 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 P08684 16954191 1497 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m B 2.8 BS02 KLN B 1 R105 S119 L210 I301 F304 E374 G481 L482 R76 S90 L181 I256 F259 E329 G436 L437 T309 F435 C442 T264 F390 C397 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1498 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m B 2.8 BS03 KLN B 2 F57 F108 S119 F28 F79 S90 T309 F435 C442 T264 F390 C397 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1499 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m C 2.8 BS01 HEM C 1 R105 I118 W126 R130 F137 F302 A305 T309 I369 R375 P434 F435 R440 N441 C442 I443 A448 M452 R76 I89 W97 R101 F108 F271 A274 T278 I338 R344 P403 F404 R409 N410 C411 I412 A417 M421 T309 F435 C442 T278 F404 C411 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 P08684 16954191 1497 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m C 2.8 BS02 KLN C 1 F57 S119 L210 F241 I301 F304 M371 R372 E374 G481 F28 S90 L181 F210 I270 F273 M340 R341 E343 G450 T309 F435 C442 T278 F404 C411 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1498 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m C 2.8 BS03 KLN C 2 F108 S119 I301 F79 S90 I270 T309 F435 C442 T278 F404 C411 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1499 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m D 2.8 BS01 HEM D 1 R105 I118 W126 R130 F137 F302 A305 T309 I369 L373 R375 P434 F435 G436 R440 N441 C442 I443 A448 M452 R76 I89 W97 R101 F108 F259 A262 T266 I326 L330 R332 P391 F392 G393 R397 N398 C399 I400 A405 M409 T309 F435 C442 T266 F392 C399 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 P08684 16954191 1497 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m D 2.8 BS02 KLN D 1 R105 S119 L210 I301 F304 A305 R372 G481 R76 S90 L181 I258 F261 A262 R329 G438 T309 F435 C442 T266 F392 C399 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1498 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 2v0m D 2.8 BS03 KLN D 2 F108 S119 F213 F79 S90 F184 T309 F435 C442 T266 F392 C399 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=140nM P08684 16954191 1499 HGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDVDFLQLMIDSQALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR